@article{mbs:/content/journal/jmm/10.1099/00222615-11-3-243, author = "Namavar, F. and De Graaff, J. and De With, C. and Maclaren, D. M.", title = "Novobiocin Resistance and Virulence of Strains of Staphylococcus Saprophyticus Isolated from Urine and Skin", journal= "Journal of Medical Microbiology", year = "1978", volume = "11", number = "3", pages = "243-248", doi = "https://doi.org/10.1099/00222615-11-3-243", url = "https://www.microbiologyresearch.org/content/journal/jmm/10.1099/00222615-11-3-243", publisher = "Microbiology Society", issn = "1473-5644", type = "Journal Article", abstract = "SUMMARY A method was developed to study virulence of coagulase-negative staphy-lococci. Our results showed that coagulase-negative staphylococci injected into adult mice by the intracerebral route did not give rise to lethal infections, whereas mice aged 2 days were much more susceptible. Novobiocin-resistant strains of Staphylococcus saprophyticus were more virulent than strains of Staphylococcus epidermidis. Strains of S. saprophyticus biotype 3 of Baird-Parker’s classification varied in virulence according to novobiocin sensitivity. In the classification of Kloos and Schleifer, S. saprophyticus biotype 3 can be subdivided into four distinct staphylococcal species, namely S. saprophyticus, S. cohnii, S. haemolyticus and S. warned. S. cohnii and S. saprophyticus were equally virulent for mice aged 2 days, but novobiocin-sensitive S. haemolyticus was less virulent. On epidemiological grounds, however, it would seem that S. saprophyticus has some undefined advantage in invading the urinary tract.", }