Effects of cephalexin, erythromycin and clindamycin on the aerobic gram-negative faecal flora in man (Plate VII) Free

Abstract

SUMMARY

The effects of 5-day courses of orally administered cephalexin, clindamycin and erythromycin on the Gram-negative, aerobic faecal flora of healthy adults were examined. The concentration of cephalexin reached in the intestine was high enough to cause the emergence of resistant Gram-negative bacteria; organisms belonging to the genera and increased to easily detectable levels. The faecal concentration of erythromycin was high and caused a severe reduction of the coliform flora. Clindamycin administration resulted in a considerable increase in the coliform count; the increase in the proportion of klebsiellae was especially marked.

Loading

Article metrics loading...

/content/journal/jmm/10.1099/00222615-11-2-125
1978-02-01
2024-03-29
Loading full text...

Full text loading...

/deliver/fulltext/jmm/11/2/medmicro-11-2-125.html?itemId=/content/journal/jmm/10.1099/00222615-11-2-125&mimeType=html&fmt=ahah

References

  1. Barker B. M., Prescott F. 1973; Antimicrobial agents in medicine. Oxford p 223
    [Google Scholar]
  2. Brumfitt W., Pursell R. 1972; Double blind trial to compare ampicillin, cephalexin, co-trimoxazole and trimethoprim in the treatment of urinary infection. Br. med. J 2:673
    [Google Scholar]
  3. Coli-Aerogenes Sub-Committee of the Society for Applied Bacteriology 1956; The nomenclature of coli-aerogenes bacteria. J. appl. Bad. 19:108
    [Google Scholar]
  4. Cowan S. T., Steel K. J. 1974 Manual for the identification of medical bacteria 2nd ed Cambridge: p 103
    [Google Scholar]
  5. Datta N., Faiers M. C., Reeves D. S., Brumfitt W., Ørskov F., Ørskov I. 1971; R-factors in Escherichia coli in faeces after oral chemotherapy in general practice. Lancet 1:312
    [Google Scholar]
  6. Department of Health and Social Security 1969; The bacteriological examination of water supplies. In Reports on public health and medical subjects No. 71, 4th ed London: p 28
    [Google Scholar]
  7. Finegold S. M., Harada N. E., Miller L. G. 1965; Lincomycin: activity against anaerobes and effect on normal human fecal flora. Antimicrob. Agents Chemother 5:659
    [Google Scholar]
  8. Gaya H., Adnitt P. I., Turner P. 1970; Changes in gut flora after cephalexin treatment. Br. med. J 3:624
    [Google Scholar]
  9. Gower P. E., Dash C. H. 1969; Cephalexin: human studies of absorption and excretion of a new cephalosporin antibiotic. Br. J. Pharm 37:738
    [Google Scholar]
  10. Grüneberg R. N., Smellie J. M., Leakey A. 1973; Changes in antibiotic sensitivities of faecal organisms in response to treatment in children with urinary tract infection. In Urinary tract infection edited by Brumfitt W., Asscher A. W. Oxford: p 131
    [Google Scholar]
  11. Hirsh D. C., Burton G. C., Blenden D. C. 1973; Effect of oral tetracycline on the occurrence of tetracycline-resistant strains of Escherichia coli in the intestinal tract of humans. Antimicrob. Agents Chemother 4:69
    [Google Scholar]
  12. McGehee R. F., Smith C. B., Wilcox C., Finland M. 1968; Comparative studies of antibacterial activity in vitro and absorption and excretion of lincomycin and clinimycin. Am. J. med. Sci 256:279
    [Google Scholar]
  13. Miles A. A., Misra S. S., Irwin J. O. 1938; The estimation of the bactericidal power of the blood. J. Hyg., Camb 38:732
    [Google Scholar]
  14. Rose H. D., Schreir J. 1968; The effect of hospitalization and antibiotic therapy on the gram negative fecal flora. Am. J. med. Sci 255:228
    [Google Scholar]
  15. Sompolinsky D., Yaron V., Alkan W. J. 1967; Microbiological changes in the human fecal flora following the administration of tetracyclines and chloramphenicol. Am. J. Proctol 18:471
    [Google Scholar]
  16. Speller D. C. E., Bruten D. M. 1972; Faecal flora after prolonged co-trimoxazole treatment. Br. med. J 3:416
    [Google Scholar]
  17. Sukchotiratana M., Linton A. H., Fletcher J. P. 1975; Antibiotics and the oral streptococci of man. J. appl. Bad 38:277
    [Google Scholar]
  18. Tedesco F. J., Barton R. W., Alpers D. H. 1974; Clindamycin-associated colitis: prospective study. Ann. intern. Med 81:429
    [Google Scholar]
  19. Viteri A. L., Howard P. H., Dyck W. P. 1974; The spectrum of lincomycin-clindamycin colitis. Gastroenterologia, Basel 66:1137
    [Google Scholar]
  20. Wick W. E. 1967; Cephalexin, a new orally absorbed cephalosporin antibiotic. Appl. Microbiol 15:765
    [Google Scholar]
  21. Winberg J., Bergstrom T., Lincoln K., Lidin-Janson G. 1973; Treatment trials in urinary tract infection (UTI) with special reference to the effect of antimicrobials on the fecal and peri-urethral flora. Clin. Nephrol 1:142
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/00222615-11-2-125
Loading
/content/journal/jmm/10.1099/00222615-11-2-125
Loading

Data & Media loading...

Most cited Most Cited RSS feed