@article{mbs:/content/journal/jmm/10.1099/00222615-11-1-7, author = "Edwards, M. and Stark, J. M.", title = "The Ability of Smooth and Rough Strains of Streptococcus Pneumoniae to Activate Human Complement by the Alternative Pathway", journal= "Journal of Medical Microbiology", year = "1978", volume = "11", number = "1", pages = "7-14", doi = "https://doi.org/10.1099/00222615-11-1-7", url = "https://www.microbiologyresearch.org/content/journal/jmm/10.1099/00222615-11-1-7", publisher = "Microbiology Society", issn = "1473-5644", type = "Journal Article", abstract = "SUMMARY Three capsulate pneumococcal strains of serotypes 1, 2 and 3, and one non-capsulate strain of serotype 47, were found to activate human complement by the alternative pathway to a similar extent over the concentration range examined. Nevertheless, the capsulate strains, in contrast to the non-capsulate, are known to require complement attachment for phagocytosis and it is therefore postulated that the toxic by-products released cause the wave of oedema characteristic of pneumococcal lobar pneumonia.", }