Chemostat studies were made of an antibiotic-producing Staphylococcus epidermidis strain (S6+), a similar, but antibiotic non-producing S. epidermidis strain (S6−), and a sensitive indicator strain of Micrococcus sp. (M7). Pure and mixed continuous cultures were investigated at low population levels (in 0.1% peptone water) and at higher levels (in 0.5% peptone water). Strain S6+ antagonised the growth of strain M7 when its colony count was maintained above 107.0 per ml, while strain S6− remained unaffected.
EvansC. G. T.,
HerbertD.,
TempestD. W.1970; The continuous cultivation of micro-organisms. 2. Construction of a chemostat. In Methods in microbiology, vol. 2, edited by J. R. Norris and D. W. Robbins. London p 277
SelwynS.,
MarshP. D.,
SethnaT. N.1976; In vitro and in vivo studies on antibiotics from skin Micrococcaceae. In Chemotherapy vol 5 edited by
WilliamsJ. D.,
GeddesA. M.
New York and London: p 391