1887

Abstract

SUMMARY

The activities against a strain of of polymyxin B, colistin (polymyxin E) and their sulphomethyl derivatives sulphomyxin and colistin sulphomethate have been examined in an in-vitro model of the urinary bladder under conditions similar to those that may operate in the therapeutic situation. In the dynamic conditions of the model, poly-myxins exhibited a reduced activity against in comparison with activity against exponentially growing cultures in a static system. Nevertheless, long-term suppression of bacterial growth was achieved with levels of polymyxin B and colistin that can be attained during therapy, whereas sulphomethylpolymyxins had little effect on bacterial growth even on prolonged exposure.

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/content/journal/jmm/10.1099/00222615-10-2-255
1977-05-01
2019-10-17
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http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/00222615-10-2-255
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