1887

Abstract

SUMMARY

Dimetridazole, a nitroimidazole drug reported to act only on obligately anaerobic micro-organisms, is widely used for the prevention and treatment of swine dysentery. Forty-four strains of the microaerophilic bacterium isolated from either healthy or diseased pigs, and a strain of , were all sensitive to dimetridazole. The sensitivities (minimal inhibitory concentration < 10 per ml) were similar to those of anaerobic bacteria. Dimetridazole inhibited growth of campylobacters in a shaken culture in air, but did not inhibit uptake of oxygen. Inhibition of growth appeared to result from an inhibition of nucleic-acid synthesis and does not seem to depend upon interference with electron transport in the catabolism of pyruvate.

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/content/journal/jmm/10.1099/00222615-10-2-233
1977-05-01
2020-01-23
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http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/00222615-10-2-233
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