In a serial investigation of the effects of immunisation with in rhesus monkeys maintained on a “human” type of cariogenic diet, the numbers of in cervical plaque, crevicular-fluid washings, fissures of teeth, and in saliva were lower in immunised animals than in sham-immunised controls. Immunisation also caused a delay in initial colonisation and a slowing of the rate of colonisation with These bacteriological changes were associated with a reduction in the smooth-surface-caries score. No relationship was found between the presence of and caries, but there was an inverse relationship between the proportions of and isolated. Increased titres of complement-fixing, haemagglutinating and precipitating antibodies to were found in the sera of immunised but not of control monkeys. A significant increase in salivary haemagglutinating antibodies was not detected. The results suggest that immunisation with causes an increase in serum antibodies and a reduction in the number of in the oral flora, and that these are associated with a reduction in dental caries.


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