1887

Abstract

SUMMARY

Although the portal of entry and mode of spread of in human leprosy are still uncertain, it is widely held that direct person-to-person skin contact is important. This assumption has ignored the fact that patients with highly bacilliferous leprosy have nasal as well as dermal infection and that, since is shed predominantly from the nose, leprosy might be an airborne infection. The present study was designed to investigate this possibility with mice exposed to airborne infection with . The conditions are described in which thymectomised-irradiated CBA strain mice exposed to aerosols sustained an immediate lung retention of 1 × 10 bacteria. Fourteen to 24 months later, 33% (10 of 30) of the mice had countable numbers of acid-fast bacilli (>2 × l0) with the characteristics of in one or more homogenates prepared from ears, foot pads, nose or lungs. Evidence is presented from the distribution of that the infection had arisen from systemic spread of bacilli initially entering the lungs rather than from multiplication of organisms locally retained there, or in the nose, at the time of airborne infection. The relevance of these results to the possible route of infection of leprosy in man is discussed.

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1977-02-01
2022-10-04
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References

  1. Browne S. G. 1966; The value of nasal smears in lepromatous leprosy. Int. J. Lepr 34:23
    [Google Scholar]
  2. Davey T. F., Rees R. J. W. 1974; The nasal discharge in leprosy; clinical and bacterio-logical aspects. Lepr. Rev. 45:121
    [Google Scholar]
  3. Druett H. A., May K. R. 1952; A wind tunnel for the study of airborne infections. J. Hyg., Comb 50:69
    [Google Scholar]
  4. Goldschmidt J. 1891; Der nasale Ursprung der Lepra. In Die Lepra auf Madeira. Leipzig p 200
    [Google Scholar]
  5. Henderson D. W. 1952; An apparatus for the study of airborne infection. J. Hyg., Camb 50:53
    [Google Scholar]
  6. Job C. K., Karat A. B. A., Karat S. 1966; The histopathological appearance of leprous rhinitis and pathogenesis of septal perforation in leprosy. J. Lar. Otol 80:718
    [Google Scholar]
  7. Junnarkar R. V. 1957; Late lesions in leprosy. Lepr India: 29:148
    [Google Scholar]
  8. Kirchheimer W. F., Storrs E. E., Binford C. H. 1972; Attempts to establish the armadillo (Dasypus novemcinctus Linn.) as a model for the study of leprosy. II. Histopathologic and bacteriologic post-mortem findings in lepromatoid leprosy in the armadillo. Int. J. Lepr 40:229
    [Google Scholar]
  9. McDougall A. C., Rees R. J. W., Weddell A. G. M., Kanan M, Wadji. 1975; The histopathology of lepromatous leprosy in the nose. Path J. 115:215
    [Google Scholar]
  10. Muir E. 1921; Handbook on leprosy. Its diagnosis, treatment and prevention. Cuttack, India:
    [Google Scholar]
  11. Muir E. 1929; Leprosy, diagnosis, treatment and prevention. 5th ed Delhi: p 53
    [Google Scholar]
  12. Pedley J. C. 1970; Composite skin contact smears: a method of demonstrating the non-emergence of Mycobacterium leprae from intact lepromatous skin. Lepr. Rev 41:31
    [Google Scholar]
  13. Pedley J. C. 1973; The nasal mucus in leprosy. Lepr. Rev 44:33
    [Google Scholar]
  14. Rees R. J. W. 1964; Limited multiplication of acid-fast bacilli in the foot pads of mice inoculated with Mycobacterium leprae. Br. J. exp. Path 45:207
    [Google Scholar]
  15. Rees R. J. W. 1965; Recent bacteriologic, immunologic and pathologic studies on experimental human leprosy in the mouse foot pad. Int. J. Lepr 33:646
    [Google Scholar]
  16. Rees R. J. W. 1966; Enhanced susceptibility of thymectomized and irradiated mice to infection with Mycobacterium leprae. Nature, Lond 211:657
    [Google Scholar]
  17. Rees R. J. W., Waters M. F. R., Weddell A. G. M., Palmer E. 1967; Experimental lepromatous leprosy. Nature, Lond 215:599
    [Google Scholar]
  18. Rees R. J. W., Meade T. W. 1974; Comparison of the modes of spread and the incidence of tuberculosis and leprosy. Lancet 1:47
    [Google Scholar]
  19. Rees R. J. W., McDougall A. C., Weddell A. G. M. 1974; The nose in mice with experimental human leprosy. Lepr. Rev 45:112
    [Google Scholar]
  20. Schaffer J. 1898; Ueber die Verbreitung der Leprabacillen von den oberen Luftwegen aus. Archs Derm 44:159
    [Google Scholar]
  21. Sticker G. 1897; Mittheilungen fiber Lepra nach Erfahrungen in Indien and Aegypten. Munch, med. Wschr 44:39, 1063
    [Google Scholar]
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