Agglutination tests showed that 5 cultures of , strain no. 18/323, which are used in Britain to assess the protective value of whoopingcough vaccine by mouse-protection tests, are not serologically identical.

“Monotypic” antisera used for the typing of Bord. pertussis by slideagglutination were found not to be serologically “pure”. A number of sera supposed to contain antibodies for factor 1 only proved to contain antibodies for a variety of other antigens, including factors 2 and 3.

Several cultures in which only factor 1 was detected by slide agglutination were used as vaccines in rabbits. The resulting antisera contained other antibodies, and in some cases large amounts of antibody for factor 2 were detected. Individual rabbits varied considerably in the relative amounts of agglutinin for factors 1, 2 and 3 produced as a result of vaccination with the same bacterial suspension.

The implications of these findings were examined in relation to the claim that immunity to whooping-cough is influenced by the serological type of the vaccine strain of .


Article metrics loading...

Loading full text...

Full text loading...


Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error