Diarrhoea and oedema disease were consistently produced in weaned pigs from one breeding farm, but not in pigs from other farms, by the oral administration of of serotype O141: K85ac. The disease was characterised by the proliferation of large numbers of these organisms in the small intestines a few days after inoculation. Diarrhoea occurred at this time. Signs of oedema disease became evident later when the numbers of the organisms in the small intestine were much lower. These pigs were also susceptible to clinical infection with other pathogenic serotypes of

No difference was found between the antibody content of the sera of the susceptible pigs and of the pigs from the other breeding farms that were resistant to the experimental disease. No increase in O or K antibodies occurred in the sera of the susceptible pigs that died or recovered after inoculation with the O141: K85ac strain; anti-haemolytic and bactericidal antibodies increased considerably.

Variation of the protein content of the ration had no obvious effect on the susceptibility of the pigs to infection, but it was not possible to infect pigs given a restricted diet or fed on barley fibre.


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