Cell walls from “mouse-virulent” strains of were found to have “aggressin” activity; the addition of isolated cell walls to a dose of staphylococci that was too low to produce any lesion on subcutaneous injection alone led to the formation of a large necro-purulent lesion. Cell walls from “mouse non-virulent” strains did not enhance lesion production in this way. A method of isolating the lesion-enhancing material from the cell walls of mouse-virulent strains is described. This material consists mainly of mucopeptide with some protein but no teichoic acid. It is resistant to heating at 100°C for 10 min., to tryptic digestion, and to treatment with periodate or formaldehyde, but is rendered soluble and subsequently destroyed by lysozyme.

The lesion-enhancing material, when injected subcutaneously into mice on a plug of cotton dust, inhibits the accumulation of oedema fluid at the site of injection. The corresponding cell-wall fraction isolated from mouse non-virulent strains not only failed to inhibit but even stimulated the exudation of oedema fluid.


Article metrics loading...

Loading full text...

Full text loading...


Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error