Differences in susceptibility of inbred and outbred infant mice to enterotoxigenic of bovine, porcine and human origin Free

Abstract

Summary

Infant mice from outbred Swiss OF1 and from inbred DBA/2, C57BL/6, BALB/cBy and CBA strains were screened for usefulness in the diarrhoea model with enterotoxigenic (ETEC) strains of bovine, porcine and human origin. Mouse strains were either weakly susceptible or not susceptible to ETEC strains of porcine or human originbearing antigen K88, 987P, CFA/I or CFA/II. In contrast, some mouse strains were highly susceptible to bovine and porcine ETEC strains bearing K99 or F41 or both antigens. Swiss OF1 and CBA infant mice were highly susceptible to one bovineETEC strain bearing antigen K99, whereas DBA/2, BALB/cBy and C57BL/6 mice exhibited nearly complete resistance to the same ETEC strain. Except DBA/2, all mouse strains were highly susceptible to bovine and porcine ETEC strains bearing antigen F41 alone or in combination with antigen K99. Challenge ETEC strains colonised intestines of all infant mice, but theyreached very high levels soon after inoculation in the diarrhoeic ones only.

Loading

Article metrics loading...

/content/journal/jmm/10.1099/00221317-31-3-185
1990-03-01
2024-03-29
Loading full text...

Full text loading...

/deliver/fulltext/jmm/31/3/medmicro-31-3-185.html?itemId=/content/journal/jmm/10.1099/00221317-31-3-185&mimeType=html&fmt=ahah

References

  1. Evans D G, Silver R P, Evans D J, Chase D G, Gorbach S L. Plasmid-controlled colonization factor associated with virulence in Escherichia coli enterotoxigenic for humans. Infect Zmmun 1975; 12:656–667
    [Google Scholar]
  2. Evans D G, Evans D J. New surface-associated heat-labile colonization factor antigen (CFA/II) produced by enterotoxigenic Escherichia coli of serogroups O6 and O8. Infect Immun 1978; 21:638–647
    [Google Scholar]
  3. Cravioto A, Scotland S M, Rowe B. Hemagglutination activity and colonization factor antigens I and II in enterotoxigenic and non-enterotoxigenic strains of Escherichia coli isolated from humans. Infect Immun 1982; 36:189–197
    [Google Scholar]
  4. Smyth C J. Two mannose-resistant haemagglutinins on enterotoxigenic Escherichia coli of serotype 06:K15:H16 or H- isolated from travellers’ and infantile diarrhoea. J Gen Microbiol 1982; 128:2081–2096
    [Google Scholar]
  5. Stirm S, Ørskov F, Ørskov I, Birch-Andersen A. Episomecarried surface antigen K88 of Escherichia coli. III Morphology. J Bacterioll 967; 93:740–748
    [Google Scholar]
  6. Jones G W, Rutter J M. Role of the K88 antigen in the pathogenesis of neonatal diarrhea caused by Escherichia coli in piglets. Infect Immun 1972; 6:918–927
    [Google Scholar]
  7. Isaacson R E, Nagy B, Moon H W. Colonization of porcine small intestine by Escherichia coli: colonization and adhesion factors of pig enteropathogens that lack K88. JInfect Dis 1977; 135:531–539
    [Google Scholar]
  8. Nagy B, Moon H W, Isaacson R E. Colonization of porcine intestine by enterotoxigenic Escherichia coli: selection of piliated forms in vivo, adhesion of piliated forms to epithelial cells in vitro, and incidence of a pilus antigen among porcine enteropathogenic E. coli. Infect Immun 1977; 16:344–352
    [Google Scholar]
  9. Ørskov I, Ørskov F, Smith H, Sojka W J. The establishment of K99, a thermolabile, transmissible Escherichia coli K antigen, previously called “Kco”, possessed by calf and lamb enteropathogenic strains. Acta Pathol Microbiol Scand[B] 1975; 83:31–36
    [Google Scholar]
  10. De Graaf F K, Roorda I. Production, purification and characterization of the fimbrial adhesive antigen F41 isolated from calf enteropathogenic Escherichia coli strain B41M. Infect Immun 1982; 36:751–758
    [Google Scholar]
  11. Morris J A, Thorns C, Scott A C, Sojka W J, Wells G A. Adhesion in vitro and in vivo associated with an adhesive antigen (F41) produced by a K99 mutant of the reference strain Escherichia coli B41. Infect Immun 1982; 36:1146–1153
    [Google Scholar]
  12. Moon H W, Nagy B, Isaacson R E, Orskov I. Occurrence of K99 antigen on Escherichia coli isolated from pigs and colonization of pig ileum by K99 + enterotoxigenic E. coli from calves and pigs. Infect Immun 1977; 15:614–620
    [Google Scholar]
  13. Morris J A, Thorns C J, Wells G A H, Scott A C, Sojka W J. The production of F41 fimbriae by piglet strains of enterotoxigenic Escherichia coli that lack K88, K99 and 987P fimbriae. J Gen Microbioll 983; 129:2753–2759
    [Google Scholar]
  14. Smith H W, Halls S. The transmissible nature of the genetic factor in Escherichia coli that controls haemolysin production. JGen Microbioll 967; 47:153–161
    [Google Scholar]
  15. Smith H W, Linggood M A. The transmissible nature of enterotoxin production in a human enteropathogenic strain of Escherichia coli. J Med Microbioll 971; 4:301–305
    [Google Scholar]
  16. Smith H W, Linggood M A. Further observations on Escherichia coli enterotoxins with particular regard to those produced by atypical piglet-strains and by calf and lamb strains: the transmissible nature of these enterotoxins and K antigen possessed by calf and lamb strains. JMed Microbioll 972; 5:243–250
    [Google Scholar]
  17. Gyles C, So M, Falkow S. The enterotoxin plasmids of Escherichia coli. J Infect Dis 1974; 130:40–49
    [Google Scholar]
  18. Duchet-Suchaux M., Le souriceau. modtle d’ttude de la diarrhée colibacillaire. Ann Microbiol (Inst. Pasteur) 1980; 131B:239–250
    [Google Scholar]
  19. Bertin A. Virulence factors of enterotoxigenic E. colistudied in the infant mouse model. Ann Rech Vét 1983; 14:169–182
    [Google Scholar]
  20. Bertin A. F41 antigen as a virulence factor in the infant mouse model of Escherichia coli diarrhoea. J Gen Microbioll 985; 131:3037–3045
    [Google Scholar]
  21. Newsome P M, Burgess M N, Burgess M R, Coney K A, Goddard M E, Morris J A. A model of acute infectious neonatal diarrhoea. JMed Microbioll 987; 23:19–28
    [Google Scholar]
  22. Duchet-Suchaux M. Infant mouse model of E. colidiarrhea: clinical protection induced by vaccination of the mothers. Ann Rech Vét 1983; 14:319–331
    [Google Scholar]
  23. Duchet-Suchaux M. Protective antigens against enterotoxigenic Escherichia coli 0101:K99, F41 in the infant mouse diarrhea model. Infect Immun 1988; 56:1364–1370
    [Google Scholar]
  24. Bertin A. Chlorpromazine and propranolol extend survival of infant mice inoculated with enterotoxigenic Escherichiacoli. Ann Rech Vét 1981; 12:137–141
    [Google Scholar]
  25. Goldhar J, Zilberberg A, Ofek I. Infant mouse model of adherence and colonization of intestinal tissues by enterotoxigenic strains of Escherichia coli isolated from humans. Infect Immun 1986; 52:205–208
    [Google Scholar]
  26. Dean A G, Ching Y C, Williams R G, Harden L B. Test for Escherichia coli enterotoxin using infant mice: application in a study of diarrhea in children in Honolulu. J Infect Dis 1972; 125:407–411
    [Google Scholar]
  27. Rutter J M, Burrows M R, Sellwood R, Gibbons R A. A genetic basis for resistance to enteric disease caused by E. coli . Nature 1975; 257:135–136
    [Google Scholar]
  28. Newsome P M, Coney K A. Synergistic rotavirus and Escherichia coli diarrheal infection of mice. Infect Immun 1985; 47:573–574
    [Google Scholar]
  29. Davidson J N, Hirsh D C. Use of the K88 antigen for in vivo bacterial competition with porcine strains of enteropathogenic Escherichia coli. Infect Immun 1975; 12:134–136
    [Google Scholar]
  30. Duchet-Suchaux M. Modèle d’éttude de la diarrhée colibacillaire chez le souriceau nouveau-né. Desjeux J. F., Ducluzeau R. La diarrhke du jeune INSERM; Paris: 1984443–454
    [Google Scholar]
  31. Moreau M C, Raibaud P, Muller M C. Relation entre le développement du sysètme immunitaire intestinal à IgA et l’établissement de la flore microbienne dans le tube digestif du souriceau holoxénique. Ann Zmmunol (Inst. Pasteur) 1982; 133D:29–39
    [Google Scholar]
  32. Kétyi I, Kuch B, Vertényi A. Stability of Escherichia coli adhesive factors K88 and K99 in mice. Acta Microbiol Acad Sci Hung 1978; 25:77–86
    [Google Scholar]
  33. Moon H W, Fung P Y, Isaacson R E, Booth G D. Effects of age, ambient temperature, and heat-stable Escherichia coli enterotoxin on intestinal transit in infant mice. Infect Immun 1979; 25:127–132
    [Google Scholar]
  34. Nagy B, Ushe T C. Colonization of infant mice by K99+ Escherichia coli and lack of colonization by Streptococcus faecium M74. Acta Vet Hung 1985; 33:143–147
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/00221317-31-3-185
Loading
/content/journal/jmm/10.1099/00221317-31-3-185
Loading

Data & Media loading...

Most cited Most Cited RSS feed