1887

Abstract

Antibody–antigen cross-reactions were examined with sera from patients with O157 infection and lipopolysaccharide (LPS) purified from a range of enterohaemorrhagic (EHEC) including those belonging to serogroups O26, O103, O111, O145 and O157. Six of 10 patients infected with an O157 EHEC produced serum antibodies that cross-reacted with common LPS-core epitopes, which were expressed by 23 of 33 strains of EHEC examined. These common LPS-core epitopes were also present on strains of O26 which did not produce verocytotoxin. These cross-reacting antibodies did not influence the basic immunoblotting procedures used for the routine serodiagnosis of infections with O157.

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2002-12-01
2019-11-20
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