1887

Abstract

is an emerging opportunist fungus that causes different types of infections in immunocompetent and immunosuppressed people. These infections show an irregular geographical distribution and, generally, disseminated systemic infections are noticed only in specific countries. This study used a murine model of disseminated infection by this fungus to assess if strains from different origins have different virulence. Two strains from each of four different sources (disseminated infection, localised infection, asymptomatic cystic fibrosis patients and the environment) were tested. Two strains of of clinical origin were also included in the study; these were clearly less virulent than those of . The strains tested were classified in three groups according to their virulence. The groups with higher and lower virulence were represented by only one strain each, and the intermediate group contained six strains. No significant differences were found between the strains from different geographic areas or different forms of disease.

Loading

Article metrics loading...

/content/journal/jmm/10.1099/0022-1317-51-11-924
2002-11-01
2024-04-19
Loading full text...

Full text loading...

/deliver/fulltext/jmm/51/11/924.html?itemId=/content/journal/jmm/10.1099/0022-1317-51-11-924&mimeType=html&fmt=ahah

References

  1. Berenguer J, Rodríguez-Tudela JL, Richard C. et al. Deep infections caused by Scedosporium prolificans .A report on 16 cases in Spain and a review of the literature. Medicine 1997; 76:256–265 [CrossRef]
    [Google Scholar]
  2. de Hoog GS, Guarro J, Gené J, Hyphomycetes Figueras MJ. Genus: Scedosporium . In: Atlas of clinical fungi, 2nd edn. Utrecht, Centraalbureau voor Schimmelcultures. 2000: 899–901
    [Google Scholar]
  3. Gosbell IB, Morris ML, Gallo JH. et al. Clinical, pathologic and epidemiologic features of infection with Scedosporium prolificans : four cases and review. Clin Microbiol Infect 1999; 5:672–686 [CrossRef]
    [Google Scholar]
  4. García E, Rodriguez V, Gartner S, Gené J. Aislamiento de Scedosporium prolificans en pacientes afectados de fibrosis quística.[Isolation of Scedosporium prolificans in patients with cystic fibrosis.]. Enferm Infecc Microbiol Clin 1998; 16:488–489
    [Google Scholar]
  5. Pontón J, Rüchel R, Clemons KV. et al. Emerging pathogens. Med Mycol 2000; 38 Suppl 1:225–236 [CrossRef]
    [Google Scholar]
  6. Alvarez M, Lopez Ponga B, Rayon C. et al. Nosocomial outbreak caused by Scedosporium prolificans ( inflatum ): four fatal cases in leukemic patients. J Clin Microbiol 1995; 33:3290–3295
    [Google Scholar]
  7. Guarro J, Gené J. Opportunistic fusarial infections in humans. Eur J Clin Microbiol Infect Dis 1995; 14:741–754 [CrossRef]
    [Google Scholar]
  8. Guarro J, Gams W, Pujol I, Gené J. Acremonium species: new emerging fungal opportunists. In vitro antifungal susceptibilities and review. Clin Infect Dis 1997; 25:1222–1229 [CrossRef]
    [Google Scholar]
  9. Latgé JP. Aspergillus fumigatus and aspergillosis. Clin Microbiol Rev 1999; 12:310–350
    [Google Scholar]
  10. Carrillo AJ, Guarro J. In vitro activities of four novel triazoles against Scedosporium spp. Antimicrob Agents Chemother 2001; 45:2151–2153 [CrossRef]
    [Google Scholar]
  11. Hennequin C, Bernailly N, Silly C. et al. In vitro susceptibilities to amphotericin B, itraconazole, and miconazole of filamentous fungi isolated from patients with cystic fibrosis. Antimicrob Agents Chemother 1997; 41:2064–2066
    [Google Scholar]
  12. Salkin IF, McGinnis MR, Dykstra MJ, Rinaldi MG. Scedosporium inflatum , an emerging pathogen. J Clin Microbiol 1988; 26:498–503
    [Google Scholar]
  13. Wilson CM, O'Rourke EJ, McGinnis MR, Salkin IF. Scedosporium inflatum : clinical spectrum of a newly recognized pathogen. J Infect Dis 1990; 161:102–107 [CrossRef]
    [Google Scholar]
  14. Wood GM, McCormack JG, Muir DB. et al. Clinical features of human infection with Scedosporium inflatum . Clin Infect Dis 1992; 14:1027–1033 [CrossRef]
    [Google Scholar]
  15. Cano J, Guarro J, Mayayo E, Fernandez-Ballart J. Experimental infection with Scedosporium inflatum . J Med Vet Mycol 1992; 30:413–420 [CrossRef]
    [Google Scholar]
  16. Drohuet E, Dupont B, Ravisse P. Étude expérimentale d'une souche hautement virulente de Scedosporium inflatum isolée d'une arthrite du genou. J Mycol Med 1991; 118:16–20
    [Google Scholar]
  17. Summerbell RC, Kradjen S, Kane J. Potted plants in hospitals as reservoirs of pathogenic fungi. Mycopathologia 1989; 106:13–22 [CrossRef]
    [Google Scholar]
  18. Durán MT, Larriba L, Rosales M, Torres JP, Molina M, Guerro A. Transmissíon cérea de Scedosporium prolificans en la infección nosocomial. Abstracts of the VIII Congreso de la Sociedad Española de Enfermedades Infecciosas y Microbiologica Clínica, Palma de Mallorca 1998316
    [Google Scholar]
  19. Muñoz P, Peláez T, Martín-Rabadán P, Rodríguez-Creixéms M, Mensalvas A, Bouza E. Incremento de las infecciones por Scedosporium prolificans en un hospital general. Abstracts of the VIII Congreso de la Sociedad Española de Enfermedades Infecciosas y Microbiologica Clínica, Palma de Mallorca 1998315
    [Google Scholar]
  20. Bell RG. Comparative virulence and immunodiffusion analysis of Petriellidium boydii (Shear) Malloch strains isolated from feedlot manure and a human mycetoma. Can J Microbiol 1978; 24:856–863 [CrossRef]
    [Google Scholar]
  21. Hennebert GL, Desai BG. Lomentospora prolificans , a new hyphomycete from greenhouse soil. Mycotaxon 1974; 1:44–50
    [Google Scholar]
  22. Walsh M, White L, Atkinson K, Enno A. Fungal Pseudoallescheria boydii lung infiltrates unresponsive to amphotericin B in leukaemic patients. Aust NZ J Med 1992; 22:265–268 [CrossRef]
    [Google Scholar]
  23. Liu K, Howell DN, Perfect JR, Schell WA. Morphologic criteria for the preliminary identification of Fusarium , Paecilomyces , and Acremonium species by histopathology. Am J Clin Pathol 1998; 109:45–54
    [Google Scholar]
  24. Guarro J, Gaztelurrutia L, Marín J, Barcena J. [ Scedosporium inflatum , a new pathogenic fungus.Report of 2 cases with a fatal outcome.]. Enferm Infecc Microbiol Clín 1991; 9:557–560
    [Google Scholar]
  25. Marín J, Sanz MA, Sanz GF. et al. Disseminated Scedosporium inflatum infection in a patient with acute myeloblastic leukaemia. Eur J Clin Microbiol Infect Dis 1991; 10:759–761 [CrossRef]
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jmm/10.1099/0022-1317-51-11-924
Loading
/content/journal/jmm/10.1099/0022-1317-51-11-924
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error