1887

Abstract

Distinct virulence factors of have been associated with clinical outcome of the infection; however, considerable variations have been reported from different geographic regions. Data on genotypes of African isolates are sparse. The aim of this study was to determine the prevalence of specific genotypes of in Nigerian patients with duodenal ulcer and non-ulcer dyspepsia. was cultured from endoscopic biopsies obtained from 41 Nigerian patients (19 with duodenal ulcer, 22 with non-ulcer dyspepsia). The allelesand genotypes were determined by PCR. The s1,m1 and s1,m2 genotypes were found in 26.3% and 22.7%, and in 73.7% and 72.7% ofisolates from patients with duodenal ulcer and non-ulcer dyspepsia, respectively. The 1 genotype was present in 94.7% and 86.4% of isolates from duodenal ulcer and non-ulcer dyspepsia patients, respectively. infection was found predominantly (>90%) in Nigerian isolates irrespective of the clinical diagnosis. In conclusion, s1,m2, 1 and are common genotypes of isolated from Nigerian patients. As in several other developing countries there seems to be no association between these genotypes and duodenal ulcer disease.

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2002-10-01
2019-11-20
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