Mucosal immunisation with Clostridium botulinum type C 16 S toxoid and its non-toxic component

References

1. Ohyama T, Watanabe T, Fujinaga Y. et al. Characterization of nontoxic-nonhemagglutinin component of the two types of progenitor toxin (M and L) produced by Clostridium botulinum Type D CB-16. . Microbiol Immunol 1995; 39:457–465 [CrossRef]
   [Google Scholar]
2. Fujinaga Y, Inoue K, Shimazaki S. et al. Molecular construction of Clostridium botulinum type C progenitor toxin and its gene organization. Biochem Biophys Res Commun 1994; 205:1291–1298 [CrossRef]
   [Google Scholar]
3. Fujita R, Fujinaga Y, Inoue K, Nakajima H, Kumon H, Oguma K. Molecular characterization of two forms of nontoxic-nonhemagglutinin components of Clostridium botulinum type A progenitor toxins. FEBS Lett 1995; 376:41–44 [CrossRef]
   [Google Scholar]
4. Inoue K, Fujinaga Y, Watanabe T. et al. Molecular composition of Clostridium botulinum type A progenitor toxins. Infect Immun 1996; 64:1589–1594
   [Google Scholar]
5. Inoue K, Fujinaga Y, Honke K. et al. Characterization of haemagglutinin activity of Clostridium botulinum type C and D 16 S toxins, and one subcomponent of haemagglutinin (HA 1). Microbiology 1999; 145:2533–2542
   [Google Scholar]
6. Oguma K, Syuto B, Iida H, Kubo S. Antigenic similarity of toxins produced by Clostridium botulinum type C and D strains. Infect Immun 1980; 30:656–660
   [Google Scholar]
7. Oguma K, Fujinaga Y, Inoue K. Clostridium botulinum toxin. J Toxicol Toxin Rev 1997; 16:253–266 [CrossRef]
   [Google Scholar]
8. Minton NP. Molecular genetics of clostridial neurotoxins. Curr Top Microbiol Immunol 1995; 195:161–194
   [Google Scholar]
9. Ohishi I, Sugii S, Sakaguchi G. Oral toxicities of Clostridium botulinum toxins in response to molecular size. Infect Immun 1977; 16:107–109
   [Google Scholar]
10. Ohishi I, Sakaguchi G. Oral toxicities of Clostridium botulinum type C and D toxins of different molecular sizes. Infect Immun 1980; 28:303–309
    [Google Scholar]
11. Sugii S, Ohishi I, Sakaguchi G. Intestinal absorption of botulinum toxins of different molecular sizes in rats. Infect Immun 1977; 17:491–496
    [Google Scholar]
12. Maksymowych AB, Reinhard M, Malizio CJ, Goodnough MC, Johnson EA, Simpson LL. Pure botulinum neurotoxin is absorbed from the stomach and small intestine and produces peripheral neuromuscular blockade. Infect Immun 1999; 67:4708–4712
    [Google Scholar]
13. Fujinaga Y, Inoue K, Watanabe S. et al. The haemagglutinin of Clostridium botulinum type C progenitor toxin plays an essential role in binding of toxin to the epithelial cells of guinea pig small intestine leading to the efficient absorption of the toxin. Microbiology 1997; 143:3841–3847 [CrossRef]
    [Google Scholar]
14. Fujinaga Y, Inoue K, Nomura T. et al. Identification and characterization of functional subunits of Clostridium botulinum type A progenitor toxin involved in binding to intestinal microvilli and erythrocytes. FEBS Lett 2000; 467:179–183 [CrossRef]
    [Google Scholar]
15. Inoue K, Fujinaga Y, Honke K. et al. Clostridium botulinum type A haemagglutinin positive progenitor toxin (HA⁺-PTX) binds to oligosaccharides containing Galβ 1-4GlcNAc through one subcomponent of haemagglutinin(HA1). Microbiology 2001; 147:811–819
    [Google Scholar]
16. Mahmut N, Inoue K, Fujinaga Y. et al. Characterization of monoclonal antibodies against haemagglutinin associated with Clostridium botulinum type C neurotoxin. J Med Microbiol 2002; 51:286–294
    [Google Scholar]
17. Oguma K, Iida H, Inoue K. Observations on nonconverting phage, c-n71, obtained from a nontoxigenic strain of Clostridium botulinum type C. Jpn J Microbiol 1975; 19:167–172 [CrossRef]
    [Google Scholar]
18. Oguma K, Iida H, Shiozaki M. Phage conversion to hemagglutinin production in Clostridium botulinum types C and D. Infect Immun 1976; 14:597–602
    [Google Scholar]
19. Hauser D, Gibert M, Eklund MW, Boquet P, Popoff MR. Comparative analysis of C3 and botulinum neurotoxin genes and their environment in Clostridium botulinum types C and D. J Bacteriol 1993; 175:7260–7268
    [Google Scholar]
20. Tsuji T, Yokochi T, Kamiya H, Kawamoto Y, Miyama A, Asano Y. Relationship between a low toxicity of the mutant A subunit of enterotoxigenic Escherichia coli enterotoxin and its strong adjuvant action. Immunology 1997; 90:176–182 [CrossRef]
    [Google Scholar]