RT Journal Article SR Electronic(1) A1 VAHABOGLU, HALUK A1 COSKUNKAN, FIGEN A1 TANSEL, OZLEM A1 OZTURK, RECEP A1 SAHIN, NURSU A1 KOKSAL, IFTAHAR A1 KOCAZEYBEK, BEKIR A1 TATMAN-OTKUN, MUSERREF A1 LEBLEBICIOGLU, HAKAN A1 OZINEL, MEHMET ALI A1 AKALIN, HALIS A1 KOCAGOZ, SESIN A1 KORTEN, VOLKANYR 2001 T1 Clinical importance of extended-spectrum β-lactamase (PER-1-type)-producing Acinetobacter spp. and Pseudomonas aeruginosa strains JF Journal of Medical Microbiology, VO 50 IS 7 SP 642 OP 645 DO https://doi.org/10.1099/0022-1317-50-7-642 PB Microbiology Society, SN 1473-5644, AB Recently, an extended-spectrum β-lactamase (PER-1) was found to be disseminated among Acinetobacter spp. and Pseudomonas aeruginosa isolates in Turkey. A population-based cohort study was conducted to elucidate predictive mortality factors in patients with nosocomial infections caused by Acinetobacter spp. and P. aeruginosa, with particular reference to PER-1-type extended-spectrum β-lactamase (ESBL) production. The study group comprised 16 and 21 non-survivors and 82 and 126 survivors in cohorts infected with Acinetobacter and P. aeruginosa, respectively. In the Acinetobacter-infected cohort, nosocomial pneumonia, hypotension and infection with a PER-positive isolate were independent predictors of mortality. In the P. aeruginosa-infected cohort, impaired consciousness, a PER-positive isolate, male sex and (with a negative relative risk) urinary tract infection were independent predictors of death. This study demonstrated the relationship of PER-1-type ESBL-producing Acinetobacter spp. and P. aeruginosa with poor clinical outcome. , UL https://www.microbiologyresearch.org/content/journal/jmm/10.1099/0022-1317-50-7-642