%0 Journal Article %A IHALIN, RIIKKA %A LOIMARANTA, VUOKKO %A LENANDER-LUMIKARI, MARIANNE %A TENOVUO, JORMA %T The sensitivity of Porphyromonas gingivalis and Fusobacterium nucleatum to different (pseudo)halide-peroxidase combinations compared with mutans streptococci %D 2001 %J Journal of Medical Microbiology, %V 50 %N 1 %P 42-48 %@ 1473-5644 %R https://doi.org/10.1099/0022-1317-50-1-42 %I Microbiology Society, %X Previous studies have shown that the peroxidase system with iodide is particularly effective against Actinobacillus actinomycetemcomitans. In the present study, the effects of iodide, chloride and thiocyanate in combinations with lactoperoxidase (LP) and myeloperoxidase (MP) on the viability of Porphyromonas gingivalis, Fusobacterium nucleatum, Streptococcus mutans and S. rattus were analysed. Bacteria were incubated in buffer solution containing peroxidase, substrate(s) and H2O2 (all in oral physiological concentrations), and plated after 0, 0.5 and 1 h. The oxidation product of iodide was the most bactericidal against all the bacteria tested. The effect was significantly weaker on mutans streptococci. Physiological concentrations of thiocyanate abolished the effects of LP-H2O2-iodide and MP-H2O2-iodide/chloride combinations. Thiocyanate-peroxidase systems have already been used in oral hygiene products. The incorporation of iodide into these products could make them much more potent against periodontal pathogens, and also help to prevent transmission of these pathogens from person to person via saliva. %U https://www.microbiologyresearch.org/content/journal/jmm/10.1099/0022-1317-50-1-42