Volume 33, Issue 3

- Volume 33, Issue 3, 1976

Volume 33, Issue 3, 1976

Articles
- - Thymus Dependence of Rabies Vaccine
    
    G. S. Turner
    
    https://doi.org/10.1099/0022-1317-33-3-535
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    SUMMARY
    Immune responses to rabies vaccine were compared with those to known thymus-dependent and thymus-independent antigens, in nude mice and their normal litter mates. No antibody response to, or protection against, challenge was observed in nude mice inoculated with either 1 or 2 doses of rabies vaccine. A single dose of the same vaccine induced a substantial antibody response and protected normal mice. These data indicate that the antigens in rabies vaccine that induce neutralizing antibody and protect mice are thymus-dependent.
    
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- Propagation of Semliki Forest Virus in Various Human Lymphoblastoid Cell Lines
  
  J. Hilfenhaus
  
  https://doi.org/10.1099/0022-1317-33-3-539
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  SUMMARY
  Semliki Forest virus (SFV) propagation was studied in one marmoset and eight human lymphoblastoid cell lines. In eight of these cell lines SFV propagated well. Only in the Daudi (human) cell line virus replication was suppressed. This suppression takes place after virus adsorption but before virus inhibitory effects on cell functions.
  
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- Isolation of the Matrix (Membrane) Protein of Vesicular Stomatitis Virus by Gel Filtration in Guanidine Hydrochloride
  
  A. P. Kendal and P. Cohen
  
  https://doi.org/10.1099/0022-1317-33-3-543
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  SUMMARY
  The L, N and M proteins of vesicular stomatitis virus (VSV) were resolved from each other by gel filtration in the presence of 6 m-guanidine hydrochloride. Amino acid analysis for purified M protein of VSV showed that its chemical composition differed from those of influenza and SV5 M proteins.
  
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- Reactivation of Herpes Simplex Virus Infection by Ultraviolet Light and Possible Involvement of Prostaglandins
  
  W. A. Blyth, T. J. Hill, H. J. Field and D. A. Harbour
  
  https://doi.org/10.1099/0022-1317-33-3-547
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  SUMMARY
  Herpes simplex infection in the mouse ear was used to investigate whether various treatments would reactivate the disease. Immunosuppressive drugs failed to induce clinical signs of reactivation but irradiation of the skin of the originally infected ear with ultraviolet light or injection of prostaglandin E2 or PBSA into this site, caused reactivation of infection. This was detected by the appearance of infectious virus in the skin 2 to 3 days after these treatments. The results are discussed in relation to the mechanism of herpes reactivation in man.
  
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- Volume 33, Issue 3, 1976

Volume 33, Issue 3, 1976

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