1887

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Volume 90, Issue 4

Acute-phase CD4 T-cell proliferation and CD152 upregulation predict set-point virus replication in vaccinated simian–human immunodeficiency virus strain 89.6p-infected macaques Free

Abstract

Human immunodeficiency virus (HIV) infection in humans and simian immunodeficiency virus (SIV) infection in macaques are accompanied by a combined early loss of CCR5 (CD195)-expressing CD4 memory T cells, loss of T-helper function and T-cell hyperactivation, which have all been associated with development of high virus load and disease progression. Here, a cohort of vaccinated simian–human immunodeficiency virus strain 89.6p (SHIV)-infected rhesus macaques, where preferential depletion of these memory T-cell subsets does not take place and CD4 T cells are relatively well maintained, was used to study the role of hyperactivation as an independent factor in the establishment of set-point virus load. In the acute phase of the infection, a transient loss of CD4 T cells, as well as strong increases in expression of proliferation and activation markers on CD4 and CD8 T cells, together with CD152 expression on CD4 T cells, were observed. Peak expression levels of these markers on CD4 T cells, but not on CD8 T cells, were correlated with high virus replication in the chronic phase of the infection. In addition, the peak expression level of these markers was correlated inversely with acute-phase, but not chronic-phase, HIV/SIV-specific gamma interferon responses. These data highlight a central role for an acute but transient CD4 decrease, as well as CD4 T-cell activation, as independent factors for prediction of set-point levels of virus replication.

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2009-04-01
2024-04-18
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Acute-phase CD4+ T-cell proliferation and CD152 upregulation predict set-point virus replication in vaccinated simian–human immunodeficiency virus strain 89.6p-infected macaques
J. Gen. Virol. 90, 915 (2009); https://doi.org/10.1099/vir.2008.006148-0
/content/journal/jgv/10.1099/vir.2008.006148-0
/content/journal/jgv/10.1099/vir.2008.006148-0
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