1887

Abstract

Investigation of sequence polymorphisms in the glycoprotein N (gN; gp4273), gO (gp4274) and gH (gp4275) genes of human cytomegalovirus (HCMV) strains collected from 63 Japanese children revealed that their gO genotype distribution differed slightly from that of Caucasian populations and that there was a significant linkage between the gN and gO genotypes. Linkage of these genotypes in strains obtained from Caucasian populations has been reported, so our similar findings in Japanese infants are consistent with this, and suggest generality of this linkage. Sequence analysis suggests that recombination between two strains of different linkage groups occurred approximately 200 bp upstream of the 3′-end of the gO gene. Further studies are required to elucidate differences in biological characteristics among the linkage groups and the selective constraints that maintain the linkage.

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2008-09-01
2020-01-24
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References

  1. Arav-Boger, R., Zong, J. C. & Foster, C. B. ( 2005; ). Loss of linkage disequilibrium and accelerated protein divergence in duplicated cytomegalovirus chemokine genes. Virus Genes 31, 65–72.[CrossRef]
    [Google Scholar]
  2. Bale, J. F., Jr, Murph, J. R., Demmler, G. J., Dawson, J., Miller, J. E. & Petheram, S. J. ( 2000; ). Intrauterine cytomegalovirus infection and glycoprotein B genotypes. J Infect Dis 182, 933–936.[CrossRef]
    [Google Scholar]
  3. Barbi, M., Binda, S., Caroppo, S., Primache, V., DidÊ, P., Guidotti, P., Corbetta, C. & Melotti, D. ( 2001; ). CMV gB genotypes and outcome of vertical transmission: study on dried blood spots of congenitally infected babies. J Clin Virol 21, 75–79.[CrossRef]
    [Google Scholar]
  4. Boppana, S. B., Rivera, L. B., Fowler, K. B., Mach, M. & Britt, W. J. ( 2001; ). Intrauterine transmission of cytomegalovirus to infants of women with preconceptional immunity. N Engl J Med 344, 1366–1371.[CrossRef]
    [Google Scholar]
  5. Chou, S. ( 1992; ). Molecular epidemiology of envelope glycoprotein H of human cytomegalovirus. J Infect Dis 166, 604–607.[CrossRef]
    [Google Scholar]
  6. Coaquette, A., Bourgeois, A., Dirand, C., Varin, A., Chen, W. & Herbein, G. ( 2004; ). Mixed cytomegalovirus glycoprotein B genotypes in immunocompromised patients. Clin Infect Dis 39, 155–161.[CrossRef]
    [Google Scholar]
  7. Dolan, A., Cunningham, C., Hector, R. D., Hassan-Walker, A. F., Lee, L., Addison, C., Dargan, D. J., McGeoch, D. J., Gatherer, D. & other authors ( 2004; ). Genetic content of wild-type human cytomegalovirus. J Gen Virol 85, 1301–1312.[CrossRef]
    [Google Scholar]
  8. Dutch, R. E., Bruckner, R. C., Mocarski, E. S. & Lehman, I. R. ( 1992; ). Herpes simplex virus type 1 recombination: role of DNA replication and viral a sequences. J Virol 66, 277–285.
    [Google Scholar]
  9. Haberland, M., Meyer-König, U. & Hufert, F. T. ( 1999; ). Variation within the glycoprotein B gene of human cytomegalovirus is due to homologous recombination. J Gen Virol 80, 1495–1500.
    [Google Scholar]
  10. Inoue, N. & Koyano, S. ( 2008; ). Evaluation of screening tests for congenital cytomegalovirus infection. Pediatr Infect Dis J 27, 182–184.
    [Google Scholar]
  11. Ishibashi, K., Tokumoto, T., Tanabe, K., Shirakawa, H., Hashimoto, K., Kushida, N., Yanagida, T., Inoue, N., Yamaguchi, O. & other authors ( 2007; ). Association of the outcome of renal transplantation with antibody response to cytomegalovirus strain-specific glycoprotein H epitopes. Clin Infect Dis 45, 60–67.[CrossRef]
    [Google Scholar]
  12. Kajino, K., Yamamoto, T., Hayashi, J., Umeda, T., Takahara, T. & Hino, O. ( 2001; ). Recombination hot spot of hepatitis B virus genome binds to members of the HMG domain protein family and the Y box binding protein family; implication of these proteins in genomic instability. Intervirology 44, 311–316.[CrossRef]
    [Google Scholar]
  13. Kumar, S., Tamura, K. & Nei, M. ( 2004; ). mega3: integrated software for molecular evolutionary genetics analysis and sequence alignment. Brief Bioinform 5, 150–163.[CrossRef]
    [Google Scholar]
  14. Magiorkinis, G., Paraskevis, D., Vandamme, A. M., Magiorkinis, E., Sypsa, V. & Hatzakis, A. ( 2003; ). In vivo characteristics of human immunodeficiency virus type 1 intersubtype recombination: determination of hot spots and correlation with sequence similarity. J Gen Virol 84, 2715–2722.[CrossRef]
    [Google Scholar]
  15. Mattick, C., Dewin, D., Polley, S., Sevilla-Reyes, E., Pignatelli, S., Rawlinson, W., Wilkinson, G., Dal Monte, P. & Gompels, U. A. ( 2004; ). Linkage of human cytomegalovirus glycoprotein gO variant groups identified from worldwide clinical isolates with gN genotypes, implications for disease associations and evidence for N-terminal sites of positive selection. Virology 318, 582–597.[CrossRef]
    [Google Scholar]
  16. Norberg, P., Liljeqvist, J. A., Bergström, T., Sammons, S., Schmid, D. S. & Loparev, V. N. ( 2006; ). Complete-genome phylogenetic approach to varicella-zoster virus evolution: genetic divergence and evidence for recombination. J Virol 80, 9569–9576.[CrossRef]
    [Google Scholar]
  17. Ogawa, H., Suzutani, T., Baba, Y., Koyano, S., Nozawa, N., Ishibashi, K., Fujieda, K., Inoue, N. & Omori, K. ( 2007; ). Etiology of severe sensorineural hearing loss in children: independent impact of congenital cytomegalovirus infection and GJB2 mutations. J Infect Dis 195, 782–788.[CrossRef]
    [Google Scholar]
  18. Peters, G. A., Tyler, S. D., Grose, C., Severini, A., Gray, M. J., Upton, C. & Tipples, G. A. ( 2006; ). A full-genome phylogenetic analysis of varicella-zoster virus reveals a novel origin of replication-based genotyping scheme and evidence of recombination between major circulating clades. J Virol 80, 9850–9860.[CrossRef]
    [Google Scholar]
  19. Pignatelli, S., Dal Monte, P., Rossini, G., Chou, S., Gojobori, T., Hanada, K., Guo, J. J., Rawlinson, W., Britt, W. & other authors ( 2003; ). Human cytomegalovirus glycoprotein N (gpUL73-gN) genomic variants: identification of a novel subgroup, geographical distribution and evidence of positive selective pressure. J Gen Virol 84, 647–655.[CrossRef]
    [Google Scholar]
  20. Pignatelli, S., Dal Monte, P., Rossini, G. & Landini, M. P. ( 2004; ). Genetic polymorphisms among human cytomegalovirus (HCMV) wild-type strains. Rev Med Virol 14, 383–410.[CrossRef]
    [Google Scholar]
  21. Poole, L. J., Zong, J. C., Ciufo, D. M., Alcendor, D. J., Cannon, J. S., Ambinder, R., Orenstein, J. M., Reitz, M. S. & Hayward, G. S. ( 1999; ). Comparison of genetic variability at multiple loci across the genomes of the major subtypes of Kaposi's sarcoma-associated herpesvirus reveals evidence for recombination and for two distinct types of open reading frame K15 alleles at the right-hand end. J Virol 73, 6646–6660.
    [Google Scholar]
  22. Puchhammer-Stöckl, E. & Görzer, I. ( 2006; ). Cytomegalovirus and Epstein-Barr virus subtypes–the search for clinical significance. J Clin Virol 36, 239–248.[CrossRef]
    [Google Scholar]
  23. Rasmussen, L. ( 1999; ). Molecular pathogenesis of human cytomegalovirus infection. Transpl Infect Dis 1, 127–134.[CrossRef]
    [Google Scholar]
  24. Rasmussen, L., Geissler, A., Cowan, C., Chase, A. & Winters, M. ( 2002; ). The genes encoding the gCIII complex of human cytomegalovirus exist in highly diverse combinations in clinical isolates. J Virol 76, 10841–10848.[CrossRef]
    [Google Scholar]
  25. Rasmussen, L., Geissler, A. & Winters, M. ( 2003; ). Inter- and intragenic variations complicate the molecular epidemiology of human cytomegalovirus. J Infect Dis 187, 809–819.[CrossRef]
    [Google Scholar]
  26. Stanton, R., Westmoreland, D., Fox, J. D., Davison, A. J. & Wilkinson, G. W. ( 2005; ). Stability of human cytomegalovirus genotypes in persistently infected renal transplant recipients. J Med Virol 75, 42–46.[CrossRef]
    [Google Scholar]
  27. Takeuchi, Y., Myers, R. & Danos, O. ( 2008; ). Recombination and population mosaic of a multifunctional viral gene, adeno-associated virus cap. PLoS ONE 3, e1634 [CrossRef]
    [Google Scholar]
  28. Trincado, D. E., Scott, G. M., White, P. A., Hunt, C., Rasmussen, L. & Rawlinson, W. D. ( 2000; ). Human cytomegalovirus strains associated with congenital and perinatal infections. J Med Virol 61, 481–487.[CrossRef]
    [Google Scholar]
  29. Yan, H., Koyano, S., Inami, Y., Yamamoto, Y., Suzutani, T., Mizuguchi, M., Ushijima, H., Kurane, I. & Inoue, N. ( 2008; ). Genetic variations in the gB, UL144 and UL149 genes of human cytomegalovirus strains collected from congenitally and post-natally infected Japanese children. Arch Virol 153, 667–674.[CrossRef]
    [Google Scholar]
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