1887

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Volume 89, Issue 9

The dual role of dendritic cells in the immune response to human immunodeficiency virus type 1 infection Free

Abstract

Many aspects of the complex interaction between human immunodeficiency virus type 1 (HIV-1) and the human immune system remain elusive. Our objective was to study these interactions, focusing on the specific roles of dendritic cells (DCs). DCs enhance HIV-1 infection processes as well as promote an antiviral immune response. We explored the implications of these dual roles. A mathematical model describing the dynamics of HIV-1, CD4 and CD8 T-cells, and DCs interacting in a human lymph node was analysed and is presented here. We have validated the behaviour of our model against non-human primate simian immunodeficiency virus experimental data and published human HIV-1 data. Our model qualitatively and quantitatively recapitulates clinical HIV-1 infection dynamics. We have performed sensitivity analyses on the model to determine which mechanisms strongly affect infection dynamics. Sensitivity analysis identifies system interactions that contribute to infection progression, including DC-related mechanisms. We have compared DC-dependent and -independent routes of CD4 T-cell infection. The model predicted that simultaneous priming and infection of T cells by DCs drives early infection dynamics when activated T-helper cell numbers are low. Further, our model predicted that, while direct failure of DC function and an indirect failure due to loss of CD4 T-helper cells are both significant contributors to infection dynamics, the former has a more significant impact on HIV-1 immunopathogenesis.

  • Received:
  • Accepted:
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2008-09-01
2024-04-19
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The dual role of dendritic cells in the immune response to human immunodeficiency virus type 1 infection
J. Gen. Virol. 89, 2228 (2008); https://doi.org/10.1099/vir.0.83600-0
/content/journal/jgv/10.1099/vir.0.83600-0
/content/journal/jgv/10.1099/vir.0.83600-0
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