RT Journal Article SR Electronic(1) A1 Paulmann, Dajana A1 Magulski, Thomas A1 Schwarz, Rebecca A1 Heitmann, Lisa A1 Flehmig, Bertram A1 Vallbracht, Angelika A1 Dotzauer, AndreasYR 2008 T1 Hepatitis A virus protein 2B suppresses beta interferon (IFN) gene transcription by interfering with IFN regulatory factor 3 activation JF Journal of General Virology, VO 89 IS 7 SP 1593 OP 1604 DO https://doi.org/10.1099/vir.0.83521-0 PB Microbiology Society, SN 1465-2099, AB Hepatitis A virus (HAV) antagonizes the innate immune response by inhibition of retinoic acid-inducible gene I-mediated and melanoma differentiation-associated gene 5-mediated beta interferon (IFN-β) gene expression. This study showed that this is due to an interaction of HAV with mitochondrial antiviral signalling protein (MAVS)-dependent signalling, in which the viral non-structural protein 2B and the protein intermediate 3ABC recently suggested in this context seem to be involved, cooperatively affecting the activities of MAVS and the kinases TANK-binding kinase 1 (TBK1) and the inhibitor of NF-κB kinase ϵ (IKKϵ). In consequence, interferon regulatory factor 3 (IRF-3) is not activated. As IRF-3 is necessary for IFN-β transcription, inhibition of this factor results in efficient suppression of IFN-β synthesis. This ability might be of vital importance for HAV, which is an exceptionally slow growing virus sensitive to IFN-β, as it allows the virus to establish infection and maintain virus replication for a longer period of time., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/vir.0.83521-0