RT Journal Article SR Electronic(1) A1 Mbulawa, Zizipho Z. A. A1 Williamson, Anna-Lise A1 Stewart, Debbie A1 Passmore, Jo-Ann S. A1 Denny, Lynette A1 Allan, Bruce A1 Marais, Dianne J.YR 2008 T1 Association of serum and mucosal neutralizing antibodies to human papillomavirus type 16 (HPV-16) with HPV-16 infection and cervical disease JF Journal of General Virology, VO 89 IS 4 SP 910 OP 914 DO https://doi.org/10.1099/vir.0.83458-0 PB Microbiology Society, SN 1465-2099, AB We investigated neutralizing antibodies to human papillomavirus type 16 (HPV-16) in serum and cervical washes from 84 women with normal cytology or cervical disease. Serum neutralizing antibodies were detected in 78 % of women infected at the cervix with HPV-16, compared with 35 % (P=0.002) of women infected with HPV-16-related types (α9 HPV types), 14 % (P<0.0001) of women infected with HPV-16 non-related types and none of HPV-uninfected women. A significant correlation between HPV-16 infection and serum HPV-16-neutralizing antibodies was observed (r s=0.97; P=0.032). Cervical neutralizing antibodies were detected in 38 % of women with HPV-16 infection and in 17 % of women infected with the HPV-16-related type HPV-31. Cervical neutralizing antibodies correlated with HPV-16 infection (r s=0.95; P=0.08), but not with cervical disease. Serum and cervical HPV-16 antibody responses were not affected significantly by human immunodeficiency virus type 1 infection. In conclusion, serum and cervical HPV-16-neutralizing antibodies were found to correlate with HPV-16 infection, but not with cervical disease., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/vir.0.83458-0