1887

Abstract

Two distinct pathways of gamma interferon (IFN-) production have been found in mice infected with lactate dehydrogenase-elevating virus. Both pathways involve natural killer cells. The first is mostly interleukin-12-independent and is not controlled by type I interferons. The second, which is suppressed by type I interferons, leads to increased levels of IFN- production and requires the secretion of interleukin-12. This regulation of IFN- production by type I interferons may help to control indirect pathogenesis induced by this cytokine.

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2007-11-01
2021-03-08
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References

  1. Cousens L. P., Orange J. S., Su H. C., Biron C. A. 1997; Interferon- α / β inhibition of interleukin 12 and interferon- γ production in vitro and endogenously during viral infection. Proc Natl Acad Sci U S A 94:634–639 [CrossRef]
    [Google Scholar]
  2. Cousens L. P., Peterson R., Hsu S., Dorner A., Altman J. D., Ahmed R., Biron C. A. 1999; Two roads diverged: interferon α / β - and interleukin 12-mediated pathways in promoting T cell interferon γ responses during viral infection. J Exp Med 189:1315–1327 [CrossRef]
    [Google Scholar]
  3. Coutelier J.-P., Brinton M. A. 2007; Lactate dehydrogenase-elevating virus. In The Mouse in Biomedical Research Diseases, 2nd edn. vol. 2 pp 215–234 Edited by Fox J. G., Barthold S. W., Davisson M. T., Newcomer C. E., Quimby F. W., Smith A. L. Burlington/San Diego/London: Academic Press;
    [Google Scholar]
  4. Crispens C. G., Jr. 1970; Effect of statolon on lactate dehydrogenase virus infection in mice. Arch Ges Virusforsch 31:191–195 [CrossRef]
    [Google Scholar]
  5. Demoulin J.-B., Louahed J., Dumoutier L., Stevens M., Renauld J.-C. 2003; MAP kinase activation by interleukin-9 in lymphoid and mast cell lines. Oncogene 22:1763–1770 [CrossRef]
    [Google Scholar]
  6. Khader S. A., Pearl J. E., Sakamoto K., Gilmartin L., Bell G. K., Jelley-Gibbs D. M., Ghilardi N., deSauvage F., Cooper A. M. 2005; IL-23 compensates for the absence of IL-12p70 and is essential for the IL-17 response during tuberculosis but is dispensable for protection and antigen-specific IFN-gamma responses if IL-12p70 is available. J Immunol 175:788–795 [CrossRef]
    [Google Scholar]
  7. Le Thi Phuong T., Van Snick J., Coutelier J.-P. 2006; Sensitization to bacterial endotoxin shock with a non-pathogenic mouse virus. In Abstracts of the 1st Joint Meeting of European Societies of Immunology, 16th European Congress of Immunology , abstract PA-2078p– 262
    [Google Scholar]
  8. Markine-Goriaynoff D., Hulhoven X., Cambiaso C. L., Monteyne P., Briet T., Gonzalez M.-D., Coulie P., Coutelier J.-P. 2002; Natural killer cell activation after infection with lactate dehydrogenase-elevating virus. J Gen Virol 83:2709–2716
    [Google Scholar]
  9. Meite M., Léonard S., El Azami El Idrissi M., Izui S., Masson P. L., Coutelier J.-P. 2000; Exacerbation of autoantibody-mediated hemolytic anemia by viral infection. J Virol 74:6045–6049 [CrossRef]
    [Google Scholar]
  10. Müller U., Steinhoff U., Reis L. F. L., Hemmi S., Pavlovic J., Zinkernagel R. M., Aguet M. 1994; Functional role of type I and type II interferons in antiviral defense. Science 264:1918–1921 [CrossRef]
    [Google Scholar]
  11. Musaji A., Cormont F., Thirion G., Cambiaso C. L., Coutelier J.-P. 2004; Exacerbation of autoantibody-mediated thrombocytopenic purpura by infection with mouse viruses. Blood 104:2102–2106 [CrossRef]
    [Google Scholar]
  12. Musaji A., Markine-Goriaynoff D., Franquin S., Thirion G., Le Thi Phuong T., Coutelier J.-P. 2006; Gamma-interferon involvement in the pathogenesis of lactate dehydrogenase-elevating virus infection. Adv Exp Med Biol 581:439–444
    [Google Scholar]
  13. Nguyen K. B., Cousens L. P., Doughty L. A., Pien G. C., Durbin J. E., Biron C. A. 2000; Interferon α / β -mediated inhibition and promotion of interferon γ : STAT1 resolves a paradox. Nat Immunol 1:70–76 [CrossRef]
    [Google Scholar]
  14. Nguyen K. B., Watford W. T., Salomon R., Hofmann S. R., Pien G. C., Morinobu A., Gadina M., O'Shea J. J., Biron C. A. 2002; Critical role for STAT4 activation by type 1 interferons in the interferon- γ response to viral infection. Science 297:2063–2066 [CrossRef]
    [Google Scholar]
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