1887

Abstract

Two distinct pathways of gamma interferon (IFN-) production have been found in mice infected with lactate dehydrogenase-elevating virus. Both pathways involve natural killer cells. The first is mostly interleukin-12-independent and is not controlled by type I interferons. The second, which is suppressed by type I interferons, leads to increased levels of IFN- production and requires the secretion of interleukin-12. This regulation of IFN- production by type I interferons may help to control indirect pathogenesis induced by this cytokine.

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2007-11-01
2019-11-13
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