%0 Journal Article %A Hmaied, Fatma %A Legrand-Abravanel, Florence %A Nicot, Florence %A Garrigues, Natalie %A Chapuy-Regaud, Sabine %A Dubois, Martine %A Njouom, Richard %A Izopet, Jacques %A Pasquier, Christophe %T Full-length genome sequences of hepatitis C virus subtype 4f %D 2007 %J Journal of General Virology, %V 88 %N 11 %P 2985-2990 %@ 1465-2099 %R https://doi.org/10.1099/vir.0.83151-0 %I Microbiology Society, %X Hepatitis C virus genotype 4 (HCV-4) is very common in central Africa, prevalent in the Middle East, and is becoming increasingly frequent among southern Europeans. We have determined the complete nucleotide sequences of HCV-4f strains and investigated their phylogenetic relationships with other genotypes. We amplified the complete genome of two HCV subtype 4f strains, IFBT84 and IFBT88. The HCV-4f strains have a total of 9181 and 9304 nt, respectively, including the 5′ untranslated region followed by a single open reading frame. There was no evidence of genomic recombination in the IFBT84 and IFBT88 strains. The sequences of the HCV-4f strain genomes are closer to those of HCV-1b than to genotypes 2, 3, 5 and 6. It is important to know the full-length sequences of HCV-4 subtypes in order to classify them correctly and to obtain more detailed knowledge about HCV epidemiology and sensitivity to interferon. %U https://www.microbiologyresearch.org/content/journal/jgv/10.1099/vir.0.83151-0