1887

Abstract

Acute-phase sera from >5 % of cases of haemorrhagic fever with renal syndrome occurring annually in Korea have been found to exhibit a fourfold or higher antibody titre to Puumala virus (PUUV) than to Hantaan virus (HTNV) by double-sandwich IgM ELISA, suggesting the existence of a PUUV-related hantavirus. Based on the phylogenetic relationships among arvicolid rodents, the royal vole () was targeted as a likely reservoir host of hantavirus. Using RT-PCR, a genetically distinct hantavirus, designated Muju virus (MUJV), was detected in lung tissue of royal voles, captured in widely separated geographical regions in Korea during 1996–2007. Pairwise analysis of the full-length S (1857 nt) and M (3634 nt) segments of MUJV indicated approximately 77 % sequence similarity with PUUV. At the amino acid level, MUJV differed from PUUV by 5.5–6.9 % (nucleocapsid) and 10.0–11.6 % (Gn and Gc envelope glycoproteins). Interstrain variation of MUJV sequences from royal voles captured in different regions suggested geographic-specific clustering. Neutralizing antibody titres against PUUV were two- to sixfold higher than to HTNV in sera of MUJV-infected . Although virus isolation attempts were unsuccessful, the collective data indicate that MUJV is a distinct hantavirus species.

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2007-11-01
2021-03-03
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References

  1. Baek L. J., Song J.-W., Park K. S., Kho E. Y., Ryu S. H., Yanagihara R., Song K.-J. 2002; Seroepizootiology of hantavirus infection in indigenous rodents in Korea, during 1995–2000. J Microbiol Biotechnol 12:53–58
    [Google Scholar]
  2. Baek L. J., Kariwa H., Lokugamage K., Yoshimatsu K., Arikawa J., Takashima I., Chung S. Y., Lee E. J., Moon S. S. other authors 2006; Soochong virus: a genetically distinct hantavirus isolated from Apodemus peninsulae in Korea. J Med Virol 78:290–297 [CrossRef]
    [Google Scholar]
  3. Brummer-Korvenkontio M., Vaheri A., Hovi T., von Bonsdorff C. H., Vuorimies J., Manni T., Penttinen K., Oker-Blom N., Lähdevirta J. 1980; Nephropathia epidemica: detection of antigen in bank voles and serologic diagnosis of human infection. J Infect Dis 141:131–134 [CrossRef]
    [Google Scholar]
  4. Gajdusek D. C. 1956; Hemorrhagic fevers in Asia: a problem in medical ecology. Geog Rev 46:20–42 [CrossRef]
    [Google Scholar]
  5. Horling J., Lundkvist A., Persson K., Mullaart M., Dzagurova T., Dekonenko A., Tkachenko E., Niklasson B. 1995; Detection and subsequent sequencing of Puumala virus from human specimens by PCR. J Clin Microbiol 33:277–282
    [Google Scholar]
  6. Horling J., Chizhikov V., Lundkvist A., Jonsson M., Ivanov L., Dekonenko A., Niklasson B., Dzagurova T., Peters C. J. other authors 1996; Khabarovsk virus: a phylogenetically and serologically distinct hantavirus isolated from Microtus fortis trapped in far-east Russia. J Gen Virol 77:687–694 [CrossRef]
    [Google Scholar]
  7. Kariwa H., Yoshizumi S., Arikawa J., Yoshimatsu K., Takahashi K., Takashima I., Hashimoto N. 1995; Evidence for the existence of Puumula-related virus among Clethrionomys rufocanus in Hokkaido, Japan. Am J Trop Med Hyg 53:222–227
    [Google Scholar]
  8. Lee H. W. 1982; Korean hemorrhagic fever. Prog Med Virol 28:96–113
    [Google Scholar]
  9. Lee H. W., Lee P. W., Johnson K. M. 1978; Isolation of the etiologic agent of Korean hemorrhagic fever. J Infect Dis 137:298–308 [CrossRef]
    [Google Scholar]
  10. Lee H. W., Baek L. J., Johnson K. M. 1982; Isolation of Hantaan virus, the etiologic agent of Korean hemorrhagic fever from wild urban rats. J Infect Dis 146:638–644 [CrossRef]
    [Google Scholar]
  11. Lee P.-W., Gibbs C. J. Jr, Gajdusek D. C., Yanagihara R. 1985; Serotypic classification of hantaviruses by indirect immunofluorescent antibody and plaque-reduction neutralization tests. J Clin Microbiol 22:940–944
    [Google Scholar]
  12. Lundkvist A., Wiger D., Horling J., Sjolander K. B., Plyusnin A., Mehl R., Vaheri A., Plyusnin A. 1998; Isolation and characterization of Puumala hantavirus from Norway: evidence for a distinct phylogenetic sublineage. J Gen Virol 79:2603–2614
    [Google Scholar]
  13. Niklasson B., Hornfeldt B., Lundkvist A., Bjorsten S., LeDuc J. 1995; Temporal dynamics of Puumala virus antibody prevalence in voles and of nephropathia epidemica incidence in humans. Am J Trop Med Hyg 53:134–140
    [Google Scholar]
  14. Nowak R. M. 1999 Walker's Mammals of the World Baltimore: Johns Hopkins University;
    [Google Scholar]
  15. Plyusnin A., Vapalahti O., Lankinen H., Lehväslaiho H., Apekina N., Myasnikov Y., Kallio-Kokko H., Henttonen H., Lundkvist A. other authors 1994a; Tula virus: a newly detected hantavirus carried by European common voles. J Virol 68:7833–7839
    [Google Scholar]
  16. Plyusnin A., Vapalahti O., Ulfves K., Lehvaslaiho H., Apekina N., Gavrilovskaya I., Blinov V., Vaheri A. 1994b; Sequences of wild Puumala virus genes show a correlation of genetic variation with geographic origin of the strains. J Gen Virol 75:405–409 [CrossRef]
    [Google Scholar]
  17. Plyusnin A., Vapalahti O., Lehvaslaiho H., Apekina N., Mikhailova T., Gavrilovskaya I., Laakkonen J., Niemimaa J., Henttonen H. other authors 1995; Genetic variation of wild Puumala viruses within the serotype, local rodent populations and individual animal. Virus Res 38:25–41 [CrossRef]
    [Google Scholar]
  18. Plyusnin A., Vapalahti O., Vaheri A. 1996; Hantaviruses: genome structure, expression and evolution. J Gen Virol 77:2677–2687 [CrossRef]
    [Google Scholar]
  19. Reip A., Haring B., Sibold C., Stohwasser R., Bautz E. K., Darai G., Meisel H., Krüger D. H. 1995; Coding strategy of the S and M genomic segments of a hantavirus representing a new subtype of the Puumala serotype. Arch Virol 140:2011–2026 [CrossRef]
    [Google Scholar]
  20. Sachar D. S., Narayan R., Song J.-W., Lee H. C., Klein T. A. 2003; Hantavirus infection in an active duty U.S. Army soldier stationed in Seoul, Korea. Mil Med 168:231–233
    [Google Scholar]
  21. Sironen T., Vaheri A., Plyusnin A. 2001; Molecular evolution of Puumala hantavirus. J Virol 75:11803–11810 [CrossRef]
    [Google Scholar]
  22. Smith M. F., Patton J. L. 1991; Variation in mitochondrial cytochrome b sequence in natural populations of South American Akodontine rodents (Muridae: Sigmodontinae). Mol Biol Evol 8:85–103
    [Google Scholar]
  23. Song J.-W., Baek L. J., Kim S. H., Kho E. Y., Kim J. H., Yanagihara R., Song K.-J. 2000; Genetic diversity of Apodemus agrarius -borne Hantaan virus in Korea. Virus Genes 21:227–232 [CrossRef]
    [Google Scholar]
  24. Song J.-W., Gligic A., Yanagihara R. 2002; Identification of Tula hantavirus in Pitymys subterraneus captured in the Cacak region of Serbia-Yugoslavia. Int J Infect Dis 6:31–36 [CrossRef]
    [Google Scholar]
  25. Song J.-W., Baek L. J., Song K.-J., Skrok A., Markowski J., Bratosiewicz J., Kordek R., Liberski P. P., Yanagihara R. 2004; Characterization of Tula virus from common voles ( Microtus arvalis ) in Poland: evidence for geographic-specific phylogenetic clustering. Virus Genes 29:239–247 [CrossRef]
    [Google Scholar]
  26. Swofford D. L. 2003 paup*: phylogenetic analysis using parsimony (*and other methods), version 4 Sunderland, MA: Sinauer Associates;
    [Google Scholar]
  27. Vapalahti O., Mustonen J., Lundkvist A., Henttonen H., Plyusnin A., Vaheri A. 2003; Hantavirus infections in Europe. Lancet Infect Dis 3:653–661 [CrossRef]
    [Google Scholar]
  28. Xiao S. Y., Spik K. W., Li D., Schmaljohn C. S. 1993; Nucleotide and deduced amino acid sequences of the M and S genome segments of two Puumala virus isolates from Russia. Virus Res 30:97–103 [CrossRef]
    [Google Scholar]
  29. Xiao S. Y., LeDuc J. W., Chu Y. K., Schmaljohn C. S. 1994; Phylogenetic analyses of virus isolates in the genus Hantavirus , family Bunyaviridae . Virology 198:205–217 [CrossRef]
    [Google Scholar]
  30. Yanagihara R., Svedmyr A., Amyx H. L., Lee P. W., Goldgaber D., Gajdusek D. C., Gibbs C. J. Jr, Nyström K. 1984; Isolation and propagation of nephropathia epidemica virus in bank voles. Scand J Infect Dis 16:225–228 [CrossRef]
    [Google Scholar]
  31. Yanagihara R., Goldgaber D., Gajdusek D. C. 1985; Propagation of nephropathia epidemica virus in Mongolian gerbils. J Virol 53:973–975
    [Google Scholar]
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