RT Journal Article SR Electronic(1) A1 Wu, Liguo A1 Hutt-Fletcher, Lindsey M.YR 2007 T1 Compatibility of the gH homologues of Epstein–Barr virus and related lymphocryptoviruses JF Journal of General Virology, VO 88 IS 8 SP 2129 OP 2136 DO https://doi.org/10.1099/vir.0.82949-0 PB Microbiology Society, SN 1465-2099, AB Glycoprotein gH, together with its chaperone gL and a third glycoprotein gB, is essential for cell–cell fusion and virus–cell fusion mediated by herpesviruses. Epstein–Barr virus (EBV), the prototype human lymphocryptovirus, requires a fourth glycoprotein gp42 to support fusion with B cells in addition to epithelial cells. Two other lymphocryptoviruses, the rhesus lymphocryptovirus (Rh-LCV) and the common marmoset lymphocryptovirus (CalHV3), have been sequenced in their entirety and each has a gp42 homologue. Combinations of proteins from EBV, Rh-LCV and CalHV3 were able to mediate fusion of epithelial cells, but, even when complexed with EBV gp42, only Rh-LCV and not CalHV3 proteins were able to mediate fusion with human B cells. CalHV3 gL was also unable to function effectively as a chaperone for EBV or Rh-LCV gH. The Rh-LCV gH homologue supported more fusion than EBV gH with an epithelial cell and supported the highest levels of fusion with a B cell. Chimeric constructs made from Rh-LCV gH and EBV gH that have 85.4 % sequence identity should prove useful for mapping the regions of gH that are of importance to fusion as a whole and to B-cell fusion in particular., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/vir.0.82949-0