1887

Abstract

Penaeid shrimp infectious myonecrosis virus (IMNV) is a monosegmented double-stranded RNA virus that forms icosahedral virions and is tentatively assigned to the family . New examinations of the IMNV genome sequence revealed features not noted in the original report. These features include (i) two encoded ‘2A-like’ motifs, which are likely involved in open reading frame (ORF) 1 polyprotein ‘cleavage’; (ii) a 199 nt overlap between the end of ORF1 in frame 1 and the start of ORF2 in frame 3; and (iii) a ‘shifty heptamer’ motif and predicted RNA pseudoknot in the region of ORF1–ORF2 overlap, which probably allow ORF2 to be translated as a fusion with ORF1 by −1 ribosomal frameshifting. Features (ii) and (iii) bring the predicted ORF2 coding strategy of IMNV more in line with that of its closest phylogenetic relative, , as well as with that of several other members of the family including .

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2007-04-01
2019-11-17
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