1887

Abstract

The presence of the novel parvovirus PARV4 and a related variant, PARV5, was recently demonstrated in pooled plasma used in the manufacture of blood and plasma-derived medicinal products. DNA sequence analysis of nearly full-length genomes of four PARV4 and two PARV5 strains from manufacturing plasma pools is now presented. Like PARV4, PARV5 encodes two non-overlapping open reading frames (ORF1 and ORF2), homologous to the non-structural and capsid proteins of other parvoviruses, respectively. A highly conserved region in ORF2 contains phospholipase A motifs involved in parvovirus infectivity. Hybridization of strand-specific probes to DNA extracted from high-titre, PARV4-positive plasma revealed that the positive and negative strands are packaged into PARV4 virions in similar quantities. This extended analysis of nearly full-length PARV4 and PARV5 sequences suggests that they are closely related genotypes and the use of a single virus name, PARV4, comprising genotypes 1 and 2 (previously termed PARV5) is proposed.

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2007-08-01
2021-07-27
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References

  1. Allander T., Tammi M. T., Eriksson M., Bjerkner A., Tiveljung-Lindell A., Andersson B. 2005; Cloning of a human parvovirus by molecular screening of respiratory tract samples. Proc Natl Acad Sci U S A 102:12891–12896 [CrossRef]
    [Google Scholar]
  2. Astell C. R., Mol C. D., Anderson W. F. 1987; Structural and functional homology of parvovirus and papovavirus polypeptides. J Gen Virol 68:885–893 [CrossRef]
    [Google Scholar]
  3. Baylis S. A., Shah N., Minor P. D. 2004; Evaluation of different assays for the detection of parvovirus B19 DNA in human plasma. J Virol Methods 121:7–16 [CrossRef]
    [Google Scholar]
  4. Baylis S. A., Fryer J. F., Grabarczyk P. 2007; Effects of probe binding mutations in an assay designed to detect parvovirus B19: implications for the quantitation of different virus genotypes. J Virol Methods 139:97–99 [CrossRef]
    [Google Scholar]
  5. Besselsen D. G., Gibson S. V., Besch-Williford C. L., Purdy G. A., Knowles R. L., Wagner J. E., Pintel D. J., Franklin C. L., Hook R. R. Jr other authors 1999; Natural and experimentally induced infection of Syrian hamsters with a newly recognized parvovirus. Lab Anim Sci 49:308–312
    [Google Scholar]
  6. Blümel J., Eis-Hübinger A. M., Stühler A., Bönsch C., Gessner M., Löwer J. 2005; Characterization of parvovirus B19 genotype 2 in KU812Ep6 cells. J Virol 79:14197–14206 [CrossRef]
    [Google Scholar]
  7. Brown K. E., Young N. S., Alving B. M., Barbosa L. H. 2001; Parvovirus B19: implications for transfusion medicine. Summary of a workshop. Transfusion 41:130–135 [CrossRef]
    [Google Scholar]
  8. Chenna R., Sugawara H., Koike T., Lopez R., Gibson T. J., Higgins D. G., Thompson J. D. 2003; Multiple sequence alignment with the clustal series of programs. Nucleic Acids Res 31:3497–3500 [CrossRef]
    [Google Scholar]
  9. Cotmore S. F., Tattersall P. 2006; Structure and organization of the viral genome. In Parvoviruses pp 73–94 Edited by Kerr J. R., Cotmore S. F., Bloom M. E., Linden R. M., Parrish C. R. London: Hodder Arnold;
    [Google Scholar]
  10. Ding C., Urabe M., Bergoin M., Kotin R. M. 2002; Biochemical characterization of Junonia coenia densovirus nonstructural protein NS-1. J Virol 76:338–345 [CrossRef]
    [Google Scholar]
  11. Fryer J. F., Kapoor A., Minor P. D., Delwart E., Baylis S. A. 2006; Novel parvovirus and related variant in human plasma. Emerg Infect Dis 12:151–154 [CrossRef]
    [Google Scholar]
  12. Fryer J. F., Lucas S. B., Padley D., Baylis S. A. 2007a; Parvoviruses PARV4/5 in hepatitis C virus–infected patient. Emerg Infect Dis 13:175–176
    [Google Scholar]
  13. Fryer J. F., Delwart E., Hecht F. M., Bernardin F., Jones M. S., Shah N., Baylis S. A. 2007b; Frequent detection of the parvoviruses, PARV4 and PARV5, in plasma from blood donors and symptomatic individuals. Transfusion 47:1054–1061 [CrossRef]
    [Google Scholar]
  14. Gallinella G., Venturoli S., Manaresi E., Musiani M., Zerbini M. 2003; B19 virus genome diversity: epidemiological and clinical correlations. J Clin Virol 28:1–13 [CrossRef]
    [Google Scholar]
  15. Hijikata M., Abe K., Win K. M., Shimizu Y. K., Keicho N., Yoshikura H. 2001; Identification of new parvovirus DNA sequence in swine sera from Myanmar. Jpn J Infect Dis 54:244–245
    [Google Scholar]
  16. Hokynar K., Söderlund-Venermo M., Pesonen M., Ranki A., Kiviluoto O., Partio E. K., Hedman K. 2002; A new parvovirus genotype persistent in human skin. Virology 302:224–228 [CrossRef]
    [Google Scholar]
  17. Hokynar K., Norja P., Laitinen H., Palomäki P., Garbarg-Chenon A., Ranki A., Hedman K., Söderlund-Venermo M. 2004; Detection and differentiation of human parvovirus variants by commercial quantitative real-time PCR tests. J Clin Microbiol 42:2013–2019 [CrossRef]
    [Google Scholar]
  18. Jones M. S., Kapoor A., Lukashov V. V., Simmonds P., Hecht F., Delwart E. 2005; New DNA viruses identified in patients with acute viral infection syndrome. J Virol 79:8230–8236 [CrossRef]
    [Google Scholar]
  19. Kumar S., Tamura K., Nei M. 2004; mega3: integrated software for molecular evolutionary genetics analysis and sequence alignment. Brief Bioinform 5:150–163 [CrossRef]
    [Google Scholar]
  20. Laub R., Strengers P. 2002; Parvoviruses and blood products. Pathol Biol 50:339–348 [CrossRef]
    [Google Scholar]
  21. Lole K. S., Bollinger R. C., Paranjape R. S., Gadkari D., Kulkarni S. S., Novak N. G., Ingersoll R., Sheppard H. W., Ray S. C. 1999; Full-length human immunodeficiency virus type I genomes from subtype C-infected seroconverters in India, with evidence of intersubtype recombination. J Virol 73:152–160
    [Google Scholar]
  22. Lukashov V. V., Goudsmit J. 2001; Evolutionary relationships among parvoviruses: virus-host coevolution among autonomous primate parvoviruses and links between adeno-associated and avian parvoviruses. J Virol 75:2729–2740 [CrossRef]
    [Google Scholar]
  23. Nguyen Q. T., Sifer C., Schneider V., Allaume X., Servant A., Bernaudin F., Auguste V., Garbarg-Chenon A. 1999; Novel human erythrovirus associated with transient aplastic anemia. J Clin Microbiol 37:2483–2487
    [Google Scholar]
  24. Nguyen Q. T., Wong S., Heegaard E. D., Brown K. E. 2002; Identification and characterization of a second novel human erythrovirus variant. A6 Virology 301374–380 [CrossRef]
  25. Parsyan A., Kerr S., Owusu-Ofori S., Elliott G., Allain J. P. 2006; Reactivity of genotype-specific recombinant proteins of human erythrovirus B19 with plasmas from areas where genotype 1 or 3 is endemic. J Clin Microbiol 44:1367–1375 [CrossRef]
    [Google Scholar]
  26. Servant A., Laperche S., Lallemand F., Marinho V., De Saint Maur G., Meritet J. F., Garbarg-Chenon A. 2002; Genetic diversity within human erythroviruses: identification of three genotypes. J Virol 76:9124–9134 [CrossRef]
    [Google Scholar]
  27. Shackelton L. A., Holmes E. C. 2006; Phylogenetic evidence for the rapid evolution of human B19 erythrovirus. J Virol 80:3666–3669 [CrossRef]
    [Google Scholar]
  28. Shackelton L. A., Parrish C. R., Truyen U., Holmes E. C. 2005; High rate of viral evolution associated with the emergence of carnivore parvovirus. Proc Natl Acad Sci U S A 102:379–384 [CrossRef]
    [Google Scholar]
  29. Shade R. O., Blundell M. C., Cotmore S. F., Tattersall P., Astell C. R. 1986; Nucleotide sequence and genome organization of human parvovirus B19 isolated from the serum of a child during aplastic crisis. J Virol 58:921–936
    [Google Scholar]
  30. Tattersall P., Bergoin M., Bloom M. E., Brown K. E., Linden R. M., Muzyczka N., Parrish C. R., Tijssen P. 2005; Family Parvoviridae . In Virus Taxonomy: Eighth Report of the International Committee on Taxonomy of Viruses pp 353–369 Edited by Fauquet C. M., Mayo M. A., Maniloff J., Desselberger U., Ball L. A. San Diego: Elsevier Academic Press;
    [Google Scholar]
  31. Zádori Z., Stefancsik R., Rauch T., Kisary J. 1995; Analysis of the complete nucleotide sequences of goose and muscovy duck parvoviruses indicates common ancestral origin with adeno-associated virus 2. Virology 212:562–573 [CrossRef]
    [Google Scholar]
  32. Zádori Z., Szelei J., Lacoste M. C., Li Y., Gariépy S., Raymond P., Allaire M., Nabi I. R., Tijssen P. 2001; A viral phospholipase A2 is required for parvovirus infectivity. Dev Cell 1:291–302 [CrossRef]
    [Google Scholar]
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