1887

Abstract

A severe limitation to fully realize the dramatic potential for adaptation of RNA virus quasispecies may occur if mutations in vast regions of the sequence space of virus genomes lead to significant decreases in biological fitness. In this study the detection and selection by heat of thermostable variants from different foot-and-mouth disease virus (FMDV) populations were attempted, in order to explore whether FMDV may generally accept a substantial increase in thermostability without compromising its infectivity. The results obtained with both uncloned and cloned populations of different serotypes, recovered from cytolytic or persistent infections and subjected to either very few passages or extensive passaging in cells, indicate that the presence of thermostable virus variants, even in small proportions, is not a general feature of FMDV quasispecies. This suggests that no substantial increase in the thermostability of FMDV may readily occur without a negative effect on viral function.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/vir.0.82521-0
2007-03-01
2019-11-13
Loading full text...

Full text loading...

/deliver/fulltext/jgv/88/3/859.html?itemId=/content/journal/jgv/10.1099/vir.0.82521-0&mimeType=html&fmt=ahah

References

  1. Bachrach, H. L., Patty, R. E. & Pledger, R. A. ( 1960; ). Thermal-resistant populations of foot-and-mouth disease virus. Proc Soc Exp Biol Med 103, 540–542.[CrossRef]
    [Google Scholar]
  2. Baranowski, E., Sevilla, N., Verdaguer, N., Ruiz-Jarabo, C. M., Beck, E. & Domingo, E. ( 1998; ). Multiple virulence determinants of foot-and-mouth disease virus in cell culture. J Virol 72, 6362–6372.
    [Google Scholar]
  3. Carrasco, C., Carreira, A., Schaap, I., Serena, P., Gómez-Herrero, J., Mateu, M. G. & de Pablo, P. J. ( 2006; ). DNA-mediated anisotropic mechanical reinforcement of a virus. Proc Natl Acad Sci U S A 103, 13706–13711.[CrossRef]
    [Google Scholar]
  4. Carreira, A. & Mateu, M. G. ( 2006; ). Structural tolerance versus functional intolerance to mutation of hydrophobic core residues surrounding cavities in a parvovirus capsid. J Mol Biol 360, 1081–1093.[CrossRef]
    [Google Scholar]
  5. Chow, M., Basavappa, R. & Hogle, J. M. ( 1997; ). The role of conformational transitions in poliovirus pathogenesis. In Structural Biology of Viruses, pp. 157–186. Edited by W. Chiu, R. M. Burnett & R. L. Garcea. Oxford: Oxford University Press.
  6. Díez, J., Dávila, M., Escarmís, C., Mateu, M. G., Domínguez, J., Pérez, J. J., Giralt, E., Melero, J. A. & Domingo, E. ( 1990; ). Unique amino acid substitutions in the capsid proteins of foot-and-mouth disease virus from a persistent infection in cell culture. J Virol 64, 5519–5528.
    [Google Scholar]
  7. Doel, T. R. ( 1985; ). Prospects for improved foot and mouth disease vaccines. Vaccine 3, 35–36.[CrossRef]
    [Google Scholar]
  8. Doel, T. R. & Baccarini, P. J. ( 1981; ). Thermal stability of foot-and-mouth disease virus. Arch Virol 70, 21–32.[CrossRef]
    [Google Scholar]
  9. Domingo, E. (editor) ( 2006; ). Quasispecies: Concept and implications for Virology (Current Topics in Microbiology and Immunology vol. 299). Berlin Heidelberg: Springer.
  10. Domingo, E. & Holland, J. J. ( 1997; ). RNA virus mutations and fitness for survival. Annu Rev Microbiol 51, 151–178.[CrossRef]
    [Google Scholar]
  11. Domingo, E., Escarmís, C., Menéndez-Arias, L. & Holland, J. J. ( 1999; ). Viral quasispecies and fitness variations. In Origin and Evolution of Viruses, pp. 141–161. Edited by E. Domingo, R. G. Webster & J. J. Holland. San Diego: Academic Press.
  12. Domingo, E., Biebricher, C., Eigen, M. & Holland, J. J. ( 2001; ). Quasispecies and RNA Virus Evolution: Principles and Consequences. Austin, TX: Landes Bioscience.
  13. Domingo, E., Ruiz-Jarabo, C. M., Arias, A., García-Arriaza, J. & Escarmís, C. ( 2004; ). Quasispecies dynamics and evolution of foot-and-mouth disease virus. In Foot-and-Mouth Disease, Current Perspectives, pp. 261–304. Edited by E. Domingo & F. Sobrino. Wymondham, UK: Horizon Bioscience.
  14. García-Arriaza, J., Manrubia, S. C., Toja, M., Domingo, E. & Escarmís, C. ( 2004; ). Evolutionary transition toward defective RNAs that are infectious by complementation. J Virol 78, 11678–11685.[CrossRef]
    [Google Scholar]
  15. Limn, C. K., Staeuber, N., Monastyrskaya, K., Gouet, P. & Roy, P. ( 2000; ). Functional dissection of the major structural protein of bluetongue virus: identification of key residues within VP7 essential for capsid assembly. J Virol 74, 8658–8669.[CrossRef]
    [Google Scholar]
  16. Mateo, R., Díaz, A., Baranowski, E. & Mateu, M. G. ( 2003; ). Complete alanine scanning of intersubunit interfaces in a foot-and-mouth disease virus capsid reveals critical contributions of many side chains to particle stability and viral function. J Biol Chem 278, 41019–41027.[CrossRef]
    [Google Scholar]
  17. Mateu, M. G. ( 1995; ). Recognition of picornaviruses by antibodies and virus escape: a structural view. Virus Res 38, 1–24.[CrossRef]
    [Google Scholar]
  18. Milstien, J. B., Lemon, S. M. & Wright, P. F. ( 1997; ). Development of a more thermostable poliovirus vaccine. J Infect Dis 175 (Suppl. 1), S247–S253.[CrossRef]
    [Google Scholar]
  19. Nettleton, P. F., Davies, M. J. & Rweyemamu, M. M. ( 1982; ). Guanidine and heat sensitivity of foot-and-mouth disease virus (FMDV) strains. J Hyg (Lond) 89, 129–138.[CrossRef]
    [Google Scholar]
  20. Pringle, C. R. ( 1964; ). Genetic aspects of the thermal inactivation properties of foot-and-mouth disease virus strains. Bull Off Int Epizoot 61, 619–628.
    [Google Scholar]
  21. Reguera, J., Carreira, A., Riolobos, L., Almendral, J. M. & Mateu, M. G. ( 2004; ). Role of interfacial amino acid residues in assembly, stability and conformation of a spherical virus capsid. Proc Natl Acad Sci U S A 101, 2724–2729.[CrossRef]
    [Google Scholar]
  22. Reguera, J., Grueso, E., Carreira, A., Sánchez-Martínez, C., Almendral, J. M. & Mateu, M. G. ( 2005; ). Functional relevance of amino acid residues involved in interactions with ordered nucleic acid in a spherical virus. J Biol Chem 280, 17969–17977.[CrossRef]
    [Google Scholar]
  23. Shiomi, H., Urasawa, T., Urasawa, S., Kobayashi, N., Abe, S. & Taniguchi, K. ( 2004; ). Isolation and characterization of poliovirus mutants resistant to heating at 50 °C for 30 min. J Med Virol 74, 484–491.[CrossRef]
    [Google Scholar]
  24. Smith, T. J., Chase, E. S., Schmidt, T. J., Olson, N. H. & Baker, T. S. ( 1996; ). Neutralizing antibody to human rhinovirus 14 penetrates the receptor-binding canyon. Nature 383, 350–354.[CrossRef]
    [Google Scholar]
  25. Sobrino, F., Dávila, M., Ortín, J. & Domingo, E. ( 1983; ). Multiple genetic variants arise in the course of replication of foot-and-mouth disease virus. Virology 128, 310–318.[CrossRef]
    [Google Scholar]
  26. Terry, G. M., Syred, A. & Rweyemamu, M. M. ( 1983; ). Studies on the stability of foot-and-mouth disease virus using absorbance-temperature profiles. Dev Biol Stand 55, 117–120.
    [Google Scholar]
  27. Verdaguer, N., Mateu, M. G., Andreu, D., Giralt, E., Domingo, E. & Fita, I. ( 1995; ). Structure of the major antigenic loop of foot-and-mouth disease virus complexed with a neutralizing antibody: direct involvement of the Arg-Gly-Asp in the interaction. EMBO J 14, 1690–1696.
    [Google Scholar]
  28. Wu, P., Xiao, W., Conlon, T., Hughes, J., Agbandje-McKenna, M., Ferkol, T., Flotte, T. & Mucyczka, N. ( 2000; ). Mutational analysis of the adeno-associated virus type 2 (AAV2) capsid gene and construction of AAV2 capsid vectors with altered tropism. J Virol 74, 8635–8647.[CrossRef]
    [Google Scholar]
  29. Zibert, A., Maass, G., Strebel, K., Falk, M. M. & Beck, E. ( 1990; ). Infectious foot-and-mouth disease virus derived from a cloned full-length cDNA. J Virol 64, 2467–2473.
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/vir.0.82521-0
Loading
/content/journal/jgv/10.1099/vir.0.82521-0
Loading

Data & Media loading...

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error