1887

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Volume 88, Issue 5

Human herpesvirus 7 infection increases the expression levels of CD46 and CD59 in target cells Free

Abstract

CD46 (membrane cofactor protein; MCP) is a molecule that functions as either a complement-regulatory protein (CRP) or a receptor for some pathogens, including human herpesvirus 6. DNA microarray analysis suggested that the expression of CD46 was upregulated in T cells infected with human herpesvirus 7 (HHV-7). Northen and Western blot analyses supported this result at both the transcriptional and translational levels. Flow-cytometric analysis revealed that upregulation of CD46 occurred at a late stage of infection in both SupT1 cells and primary CD4 T cells, and also that expression of another CRP, CD59, was increased at a late stage of infection. Whether these CRPs actually function in HHV-7-infected cells was addressed and it was found that HHV-7-infected cells were more resistant to complement-dependent cytotoxicity than were uninfected cells. This study is the first report demonstrating that HHV-7 infection causes elevation of the CRPs CD46 and CD59, which may be a possible mechanism for HHV-7 to evade humoral immunity via complement.

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2007-05-01
2024-04-25
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Human herpesvirus 7 infection increases the expression levels of CD46 and CD59 in target cells
J. Gen. Virol. 88, 1415 (2007); https://doi.org/10.1099/vir.0.82394-0
/content/journal/jgv/10.1099/vir.0.82394-0
/content/journal/jgv/10.1099/vir.0.82394-0
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