1887

Abstract

The utility of rectal lymphoid tissue sampling for the diagnosis of chronic wasting disease (CWD) infections in mule deer () and white-tailed deer () was evaluated. CWD-associated prion protein (PrP) deposits were observed in the rectal mucosa from 19 orally inoculated mule deer by 381 days post-inoculation (p.i.); similarly, 45 out of 50 naturally infected mule deer had PrP in their rectal mucosa. In orally inoculated white-tailed deer, the presence of glycine (G) or serine (S) at codon 96 of the native PrP (denoted 96GG, 96GS or 96SS) appeared to influence the temporal patterns of PrP deposition: nine out of 11 infected 96GG individuals had PrP in their rectal mucosa by 342 days p.i., whereas only three out of seven infected 96GS individuals had PrP in their rectal mucosa by 381 days p.i. and none of three 96SS individuals had PrP in their rectal mucosa by 751 days p.i. These findings support further evaluation of rectal mucosa sampling in CWD surveillance.

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2007-07-01
2019-11-20
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