1887

Abstract

The rhadinovirus (OvHV-2) is the causative agent of sheep-associated malignant catarrhal fever. OvHV-2 primarily affects ruminants and has a worldwide distribution. In this study, a composite sequence of OvHV-2 genomic DNA isolated from nasal secretions of sheep experiencing virus-shedding episodes was determined and compared with the sequence of OvHV-2 DNA isolated from a lymphoblastoid cell line derived from a clinically affected cow. The study confirmed the OvHV-2 sequence information determined for the cell line-isolated DNA and showed no apparently significant changes in the OvHV-2 genome during passage through a clinically susceptible species with subsequent maintenance . Amino acid identity between the predicted open reading frames (ORFs) of the two genomes was 94–100 %, except for ORF73, which had an identity of 83 %. Polymorphism in ORF73 was due primarily to variability in the G/E-rich repetitive central region of the ORF.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/vir.0.82285-0
2007-01-01
2019-12-09
Loading full text...

Full text loading...

/deliver/fulltext/jgv/88/1/40.html?itemId=/content/journal/jgv/10.1099/vir.0.82285-0&mimeType=html&fmt=ahah

References

  1. Albrecht, J.-C., Nicholas, J., Biller, D., Cameron, K. R., Biesinger, B., Newman, C., Wittmann, S., Craxton, M. A., Coleman, H. & other authors ( 1992; ). Primary structure of the herpesvirus saimiri genome. J Virol 66, 5047–5058.
    [Google Scholar]
  2. Alexander, L., Denekamp, L., Knapp, A., Auerbach, M. R., Damania, B. & Desrosiers, R. C. ( 2000; ). The primary sequence of rhesus monkey rhadinovirus isolate 26-95: sequence similarities to Kaposi's sarcoma-associated herpesvirus and rhesus monkey rhadinovirus isolate 17577. J Virol 74, 3388–3398.[CrossRef]
    [Google Scholar]
  3. AuCoin, D. P. & Pari, G. S. ( 2002; ). The human herpesvirus-8 (Kaposi's sarcoma-associated herpesvirus) ORF 40/41 region encodes two distinct transcripts. J Gen Virol 83, 189–193.
    [Google Scholar]
  4. Baxter, S. I. F., Pow, I., Bridgen, A. & Reid, H. W. ( 1993; ). PCR detection of the sheep-associated agent of malignant catarrhal fever. Arch Virol 132, 145–159.[CrossRef]
    [Google Scholar]
  5. Buxton, D., Reid, H. W., Finlayson, J. & Pow, I. ( 1984; ). Pathogenesis of ‘sheep-associated’ malignant catarrhal fever in rabbits. Res Vet Sci 36, 205–211.
    [Google Scholar]
  6. Coulter, L. J. & Reid, H. W. ( 2002; ). Isolation and expression of three open reading frames from ovine herpesvirus-2. J Gen Virol 83, 533–543.
    [Google Scholar]
  7. Coulter, L. J., Wright, H. & Reid, H. W. ( 2001; ). Molecular genomic characterization of the viruses of malignant catarrhal fever. J Comp Pathol 124, 2–19.[CrossRef]
    [Google Scholar]
  8. Crawford, T., O'Toole, D. T. & Li, H. ( 1999; ). Malignant catarrhal fever. In Current Veterinary Therapy 4: Food Animal Practice, 4th edn, pp. 306–309. Edited by J. L. Howard & R. A. Smith. Philadelphia, PA: W. B. Saunders.
  9. Dunowska, M., Letchworth, G. J., Collins, J. K. & DeMartini, J. C. ( 2001; ). Ovine herpesvirus-2 glycoprotein B sequences from tissues of ruminant malignant catarrhal fever cases and healthy sheep are highly conserved. J Gen Virol 82, 2785–2790.
    [Google Scholar]
  10. Ensser, A., Pflanz, R. & Fleckenstein, B. ( 1997; ). Primary structure of the alcelaphine herpesvirus 1 genome. J Virol 71, 6517–6525.
    [Google Scholar]
  11. Ensser, A., Thurau, M., Wittmann, S. & Fickenscher, H. ( 2003; ). The genome of herpesvirus saimiri C488 which is capable of transforming human T cells. Virology 314, 471–487.[CrossRef]
    [Google Scholar]
  12. Fixman, E. D., Hayward, G. S. & Hayward, S. D. ( 1995; ). Replication of Epstein-Barr virus oriLyt: lack of a dedicated virally encoded origin-binding protein and dependence on Zta in cotransfection assays. J Virol 69, 2998–3006.
    [Google Scholar]
  13. Gao, S.-J., Zhang, Y.-J., Deng, J.-H., Rabkin, C. S., Flore, O. & Jenson, H. B. ( 1999; ). Molecular polymorphism of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) latent nuclear antigen: evidence for a large repertoire of viral genotypes and dual infection with different viral genotypes. J Infect Dis 180, 1466–1476.[CrossRef]
    [Google Scholar]
  14. Handley, J. A., Sargan, D. R., Herring, A. J. & Reid, H. W. ( 1995; ). Identification of a region of the alcelaphine herpesvirus-1 genome associated with virulence for rabbits. Vet Microbiol 47, 167–181.[CrossRef]
    [Google Scholar]
  15. Hart, J., Ackermann, M., Jayawardane, G., Russell, G., Haig, D. M., Reid, H. & Stewart, J. P. ( 2007; ). Complete sequence and analysis of the ovine herpesvirus 2 genome. J Gen Virol 88, 28–39.[CrossRef]
    [Google Scholar]
  16. Hüssy, D., Janett, F., Albini, S., Stäuber, N., Thun, R. & Ackermann, M. ( 2002; ). Analysis of the pathogenetic basis for shedding and transmission of ovine gamma herpesvirus 2. J Clin Microbiol 40, 4700–4704.[CrossRef]
    [Google Scholar]
  17. Kedes, D. H., Lagunoff, M., Renne, R. & Ganem, D. ( 1997; ). Identification of the gene encoding the major latency-associated nuclear antigen of the Kaposi's sarcoma-associated herpesvirus. J Clin Invest 100, 2606–2610.[CrossRef]
    [Google Scholar]
  18. Kieff, E. ( 1996; ). Epstein-Barr virus and its replication. In Fields Virology, 3rd edn, pp. 2343–2396. Edited by B. N. Fields, D. M. Knipe & P. M. Howley. Philadelphia, PA: Lippincott–Raven.
  19. Kim, O., Li, H. & Crawford, T. B. ( 2003; ). Demonstration of sheep-associated malignant catarrhal fever virions in sheep nasal secretions. Virus Res 98, 117–122.[CrossRef]
    [Google Scholar]
  20. Koomey, J. M., Mulder, C., Burghoff, R. L., Fleckenstein, B. & Desrosiers, R. C. ( 1984; ). Deletion of DNA sequences in a nononcogenic variant of Herpesvirus saimiri. J Virol 50, 662–665.
    [Google Scholar]
  21. Li, H., Shen, D. T., O'Toole, D. T., Knowles, D. P., Gorham, J. R. & Crawford, T. B. ( 1995; ). Investigation of sheep-associated malignant catarrhal fever virus infection in ruminants by PCR and competitive inhibition enzyme-linked immunosorbent assay. J Clin Microbiol 33, 2048–2053.
    [Google Scholar]
  22. Li, H., Taus, N. S., Lewis, G. S., Kim, O., Traul, D. L. & Crawford, T. B. ( 2004; ). Shedding of ovine herpesvirus 2 in sheep nasal secretions: the predominant mode for transmission. J Clin Microbiol 42, 5558–5564.[CrossRef]
    [Google Scholar]
  23. Li, H., Taus, N. S., Jones, C., Murphy, B., Evermann, J. F. & Crawford, T. B. ( 2006; ). A devastating outbreak of malignant catarrhal fever in a bison feedlot. J Vet Diagn Invest 18, 119–123.[CrossRef]
    [Google Scholar]
  24. Loken, T., Aleksandersen, M., Reid, H. & Pow, I. ( 1998; ). Malignant catarrhal fever caused by ovine herpesvirus-2 in pigs in Norway. Vet Rec 143, 464–467.[CrossRef]
    [Google Scholar]
  25. Macrae, A. I., Dutia, B. M., Milligan, S., Brownstein, D. G., Allen, D. J., Mistrikova, J., Davison, A. J., Nash, A. A. & Stewart, J. P. ( 2001; ). Analysis of a novel strain of murine gammaherpesvirus reveals a genomic locus important for acute pathogenesis. J Virol 75, 5315–5327.[CrossRef]
    [Google Scholar]
  26. Plowright, W. ( 1990; ). Malignant catarrhal fever virus. In Virus Infections of Ruminants, 3rd edn, pp. 123–150. Edited by Z. Dinter & B. Morein. New York: Elsevier Science.
  27. Rainbow, L., Platt, G. M., Simpson, G. R., Sarid, R., Gao, S.-J., Stoiber, H., Herrington, C. S., Moore, P. S. & Schulz, T. F. ( 1997; ). The 222- to 234-kilodalton latent nuclear protein (LNA) of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) is encoded by orf73 and is a component of the latency-associated nuclear antigen. J Virol 71, 5915–5921.
    [Google Scholar]
  28. Reid, H. W. ( 1992; ). The biology of a fatal herpesvirus infection of deer (malignant catarrhal fever). In The Biology of Deer, pp. 93–100. Edited by R. D. Brown. New York: Springer.
  29. Reid, H. W., Buxton, D., Pow, I., Finlayson, J. & Berrie, E. L. ( 1983; ). A cytotoxic T-lymphocyte line propagated from a rabbit infected with sheep associated malignant catarrhal fever. Res Vet Sci 34, 109–113.
    [Google Scholar]
  30. Reid, H. W., Buxton, D., Pow, I. & Finlayson, J. ( 1989; ). Isolation and characterisation of lymphoblastoid cells from cattle and deer affected with ‘sheep-associated’ malignant catarrhal fever. Res Vet Sci 47, 90–96.
    [Google Scholar]
  31. Russo, J. J., Bohenzky, R. A., Chien, M.-C., Chen, J., Yan, M., Maddalena, D., Parry, J. P., Peruzzi, D., Edelman, I. S. & other authors ( 1996; ). Nucleotide sequence of the Kaposi sarcoma-associated herpesvirus (HHV8). Proc Natl Acad Sci U S A 93, 14862–14867.[CrossRef]
    [Google Scholar]
  32. Schock, A., Collins, R. A. & Reid, H. W. ( 1998; ). Phenotype, growth regulation and cytokine transcription in Ovine herpesvirus-2 (OHV-2)-infected bovine T-cell lines. Vet Immunol Immunopathol 66, 67–81.[CrossRef]
    [Google Scholar]
  33. Taus, N. S., Traul, D. L., Oaks, J. L., Crawford, T. B., Lewis, G. S. & Li, H. ( 2005; ). Experimental infection of sheep with ovine herpesvirus 2 via aerosolization of nasal secretions. J Gen Virol 86, 575–579.[CrossRef]
    [Google Scholar]
  34. Verma, S. C. & Robertson, E. S. ( 2003; ). Molecular biology and pathogenesis of Kaposi sarcoma-associated herpesvirus. FEMS Microbiol Lett 222, 155–163.[CrossRef]
    [Google Scholar]
  35. Virgin, H. W., IV, Latreille, P., Wamsley, P., Hallsworth, K., Weck, K. E., Dal Canto, A. J. & Speck, S. H. ( 1997; ). Complete sequence and genomic analysis of murine gammaherpesvirus 68. J Virol 71, 5894–5904.
    [Google Scholar]
  36. Wright, H., Stewart, J. P., Ireri, R. G., Campbell, I., Pow, I., Reid, H. W. & Haig, D. M. ( 2003; ). Genome re-arrangements associated with loss of pathogenicity of the γ-herpesvirus alcelaphine herpesviurs-1. Res Vet Sci 75, 163–168.[CrossRef]
    [Google Scholar]
  37. Yu, Y., Black, J. B., Goldsmith, C. S., Browning, P. J., Bhalla, K. & Offermann, M. K. ( 1999; ). Induction of human herpesvirus-8 DNA replication and transcription by butyrate and TPA in BCBL-1 cells. J Gen Virol 80, 83–90.
    [Google Scholar]
  38. Zhang, Y.-J., Deng, J.-H., Rabkin, C. & Gao, S.-J. ( 2000; ). Hot-spot variations of Kaposi's sarcoma-associated herpesvirus latent nuclear antigen and application in genotyping by PCR–RFLP. J Gen Virol 81, 2049–2058.
    [Google Scholar]
  39. Zimmermann, W., Broll, H., Ehlers, B., Buhk, H. J., Rosenthal, A. & Goltz, M. ( 2001; ). Genome sequence of bovine herpesvirus 4, a bovine Rhadinovirus, and identification of an origin of DNA replication. J Virol 75, 1186–1194.[CrossRef]
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/vir.0.82285-0
Loading
/content/journal/jgv/10.1099/vir.0.82285-0
Loading

Data & Media loading...

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error