1887

Abstract

The rhadinovirus (OvHV-2) is the causative agent of sheep-associated malignant catarrhal fever. OvHV-2 primarily affects ruminants and has a worldwide distribution. In this study, a composite sequence of OvHV-2 genomic DNA isolated from nasal secretions of sheep experiencing virus-shedding episodes was determined and compared with the sequence of OvHV-2 DNA isolated from a lymphoblastoid cell line derived from a clinically affected cow. The study confirmed the OvHV-2 sequence information determined for the cell line-isolated DNA and showed no apparently significant changes in the OvHV-2 genome during passage through a clinically susceptible species with subsequent maintenance . Amino acid identity between the predicted open reading frames (ORFs) of the two genomes was 94–100 %, except for ORF73, which had an identity of 83 %. Polymorphism in ORF73 was due primarily to variability in the G/E-rich repetitive central region of the ORF.

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2007-01-01
2021-03-04
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References

  1. Albrecht J.-C., Nicholas J., Biller D., Cameron K. R., Biesinger B., Newman C., Wittmann S., Craxton M. A., Coleman H. other authors 1992; Primary structure of the herpesvirus saimiri genome. J Virol 66:5047–5058
    [Google Scholar]
  2. Alexander L., Denekamp L., Knapp A., Auerbach M. R., Damania B., Desrosiers R. C. 2000; The primary sequence of rhesus monkey rhadinovirus isolate 26-95: sequence similarities to Kaposi's sarcoma-associated herpesvirus and rhesus monkey rhadinovirus isolate 17577. J Virol 74:3388–3398 [CrossRef]
    [Google Scholar]
  3. AuCoin D. P., Pari G. S. 2002; The human herpesvirus-8 (Kaposi's sarcoma-associated herpesvirus) ORF 40/41 region encodes two distinct transcripts. J Gen Virol 83:189–193
    [Google Scholar]
  4. Baxter S. I. F., Pow I., Bridgen A., Reid H. W. 1993; PCR detection of the sheep-associated agent of malignant catarrhal fever. Arch Virol 132:145–159 [CrossRef]
    [Google Scholar]
  5. Buxton D., Reid H. W., Finlayson J., Pow I. 1984; Pathogenesis of ‘sheep-associated’ malignant catarrhal fever in rabbits. Res Vet Sci 36:205–211
    [Google Scholar]
  6. Coulter L. J., Reid H. W. 2002; Isolation and expression of three open reading frames from ovine herpesvirus-2. J Gen Virol 83:533–543
    [Google Scholar]
  7. Coulter L. J., Wright H., Reid H. W. 2001; Molecular genomic characterization of the viruses of malignant catarrhal fever. J Comp Pathol 124:2–19 [CrossRef]
    [Google Scholar]
  8. Crawford T., O'Toole D. T., Li H. 1999; Malignant catarrhal fever. In Current Veterinary Therapy 4: Food Animal Practice . , 4th edn. pp  306–309 Edited by Howard J. L., Smith R. A. Philadelphia, PA: W. B. Saunders;
  9. Dunowska M., Letchworth G. J., Collins J. K., DeMartini J. C. 2001; Ovine herpesvirus-2 glycoprotein B sequences from tissues of ruminant malignant catarrhal fever cases and healthy sheep are highly conserved. J Gen Virol 82:2785–2790
    [Google Scholar]
  10. Ensser A., Pflanz R., Fleckenstein B. 1997; Primary structure of the alcelaphine herpesvirus 1 genome. J Virol 71:6517–6525
    [Google Scholar]
  11. Ensser A., Thurau M., Wittmann S., Fickenscher H. 2003; The genome of herpesvirus saimiri C488 which is capable of transforming human T cells. Virology 314:471–487 [CrossRef]
    [Google Scholar]
  12. Fixman E. D., Hayward G. S., Hayward S. D. 1995; Replication of Epstein-Barr virus oriLyt: lack of a dedicated virally encoded origin-binding protein and dependence on Zta in cotransfection assays. J Virol 69:2998–3006
    [Google Scholar]
  13. Gao S.-J., Zhang Y.-J., Deng J.-H., Rabkin C. S., Flore O., Jenson H. B. 1999; Molecular polymorphism of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) latent nuclear antigen: evidence for a large repertoire of viral genotypes and dual infection with different viral genotypes. J Infect Dis 180:1466–1476 [CrossRef]
    [Google Scholar]
  14. Handley J. A., Sargan D. R., Herring A. J., Reid H. W. 1995; Identification of a region of the alcelaphine herpesvirus-1 genome associated with virulence for rabbits. Vet Microbiol 47:167–181 [CrossRef]
    [Google Scholar]
  15. Hart J., Ackermann M., Jayawardane G., Russell G., Haig D. M., Reid H., Stewart J. P. 2007; Complete sequence and analysis of the ovine herpesvirus 2 genome. J Gen Virol 88:28–39 [CrossRef]
    [Google Scholar]
  16. Hüssy D., Janett F., Albini S., Stäuber N., Thun R., Ackermann M. 2002; Analysis of the pathogenetic basis for shedding and transmission of ovine gamma herpesvirus 2. J Clin Microbiol 40:4700–4704 [CrossRef]
    [Google Scholar]
  17. Kedes D. H., Lagunoff M., Renne R., Ganem D. 1997; Identification of the gene encoding the major latency-associated nuclear antigen of the Kaposi's sarcoma-associated herpesvirus. J Clin Invest 100:2606–2610 [CrossRef]
    [Google Scholar]
  18. Kieff E. 1996; Epstein-Barr virus and its replication. In Fields Virology , 3rd edn. pp  2343–2396 Edited by Fields B. N., Knipe D. M., Howley P. M. Philadelphia, PA: Lippincott–Raven;
    [Google Scholar]
  19. Kim O., Li H., Crawford T. B. 2003; Demonstration of sheep-associated malignant catarrhal fever virions in sheep nasal secretions. Virus Res 98:117–122 [CrossRef]
    [Google Scholar]
  20. Koomey J. M., Mulder C., Burghoff R. L., Fleckenstein B., Desrosiers R. C. 1984; Deletion of DNA sequences in a nononcogenic variant of Herpesvirus saimiri . J Virol 50:662–665
    [Google Scholar]
  21. Li H., Shen D. T., O'Toole D. T., Knowles D. P., Gorham J. R., Crawford T. B. 1995; Investigation of sheep-associated malignant catarrhal fever virus infection in ruminants by PCR and competitive inhibition enzyme-linked immunosorbent assay. J Clin Microbiol 33:2048–2053
    [Google Scholar]
  22. Li H., Taus N. S., Lewis G. S., Kim O., Traul D. L., Crawford T. B. 2004; Shedding of ovine herpesvirus 2 in sheep nasal secretions: the predominant mode for transmission. J Clin Microbiol 42:5558–5564 [CrossRef]
    [Google Scholar]
  23. Li H., Taus N. S., Jones C., Murphy B., Evermann J. F., Crawford T. B. 2006; A devastating outbreak of malignant catarrhal fever in a bison feedlot. J Vet Diagn Invest 18:119–123 [CrossRef]
    [Google Scholar]
  24. Loken T., Aleksandersen M., Reid H., Pow I. 1998; Malignant catarrhal fever caused by ovine herpesvirus-2 in pigs in Norway. Vet Rec 143:464–467 [CrossRef]
    [Google Scholar]
  25. Macrae A. I., Dutia B. M., Milligan S., Brownstein D. G., Allen D. J., Mistrikova J., Davison A. J., Nash A. A., Stewart J. P. 2001; Analysis of a novel strain of murine gammaherpesvirus reveals a genomic locus important for acute pathogenesis. J Virol 75:5315–5327 [CrossRef]
    [Google Scholar]
  26. Plowright W. 1990; Malignant catarrhal fever virus. In Virus Infections of Ruminants . , 3rd edn. pp  123–150 Edited by Dinter Z., Morein B. New York: Elsevier Science;
  27. Rainbow L., Platt G. M., Simpson G. R., Sarid R., Gao S.-J., Stoiber H., Herrington C. S., Moore P. S., Schulz T. F. 1997; The 222- to 234-kilodalton latent nuclear protein (LNA) of Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) is encoded by orf73 and is a component of the latency-associated nuclear antigen. J Virol 71:5915–5921
    [Google Scholar]
  28. Reid H. W. 1992; The biology of a fatal herpesvirus infection of deer (malignant catarrhal fever. In The Biology of Deer pp  93–100 Edited by Brown R. D. New York: Springer;
    [Google Scholar]
  29. Reid H. W., Buxton D., Pow I., Finlayson J., Berrie E. L. 1983; A cytotoxic T-lymphocyte line propagated from a rabbit infected with sheep associated malignant catarrhal fever. Res Vet Sci 34:109–113
    [Google Scholar]
  30. Reid H. W., Buxton D., Pow I., Finlayson J. 1989; Isolation and characterisation of lymphoblastoid cells from cattle and deer affected with ‘sheep-associated’ malignant catarrhal fever. Res Vet Sci 47:90–96
    [Google Scholar]
  31. Russo J. J., Bohenzky R. A., Chien M.-C., Chen J., Yan M., Maddalena D., Parry J. P., Peruzzi D., Edelman I. S. other authors 1996; Nucleotide sequence of the Kaposi sarcoma-associated herpesvirus (HHV8). Proc Natl Acad Sci U S A 93:14862–14867 [CrossRef]
    [Google Scholar]
  32. Schock A., Collins R. A., Reid H. W. 1998; Phenotype, growth regulation and cytokine transcription in Ovine herpesvirus-2 (OHV-2)-infected bovine T-cell lines. Vet Immunol Immunopathol 66:67–81 [CrossRef]
    [Google Scholar]
  33. Taus N. S., Traul D. L., Oaks J. L., Crawford T. B., Lewis G. S., Li H. 2005; Experimental infection of sheep with ovine herpesvirus 2 via aerosolization of nasal secretions. J Gen Virol 86:575–579 [CrossRef]
    [Google Scholar]
  34. Verma S. C., Robertson E. S. 2003; Molecular biology and pathogenesis of Kaposi sarcoma-associated herpesvirus. FEMS Microbiol Lett 222:155–163 [CrossRef]
    [Google Scholar]
  35. Virgin H. W. IV, Latreille P., Wamsley P., Hallsworth K., Weck K. E., Dal Canto A. J., Speck S. H. 1997; Complete sequence and genomic analysis of murine gammaherpesvirus 68. J Virol 71:5894–5904
    [Google Scholar]
  36. Wright H., Stewart J. P., Ireri R. G., Campbell I., Pow I., Reid H. W., Haig D. M. 2003; Genome re-arrangements associated with loss of pathogenicity of the γ -herpesvirus alcelaphine herpesviurs-1. Res Vet Sci 75:163–168 [CrossRef]
    [Google Scholar]
  37. Yu Y., Black J. B., Goldsmith C. S., Browning P. J., Bhalla K., Offermann M. K. 1999; Induction of human herpesvirus-8 DNA replication and transcription by butyrate and TPA in BCBL-1 cells. J Gen Virol 80:83–90
    [Google Scholar]
  38. Zhang Y.-J., Deng J.-H., Rabkin C., Gao S.-J. 2000; Hot-spot variations of Kaposi's sarcoma-associated herpesvirus latent nuclear antigen and application in genotyping by PCR–RFLP. J Gen Virol 81:2049–2058
    [Google Scholar]
  39. Zimmermann W., Broll H., Ehlers B., Buhk H. J., Rosenthal A., Goltz M. 2001; Genome sequence of bovine herpesvirus 4, a bovine Rhadinovirus , and identification of an origin of DNA replication. J Virol 75:1186–1194 [CrossRef]
    [Google Scholar]
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