RT Journal Article SR Electronic(1) A1 Ren, Wuze A1 Li, Wendong A1 Yu, Meng A1 Hao, Pei A1 Zhang, Yuan A1 Zhou, Peng A1 Zhang, Shuyi A1 Zhao, Guoping A1 Zhong, Yang A1 Wang, Shengyue A1 Wang, Lin-Fa A1 Shi, ZhengliYR 2006 T1 Full-length genome sequences of two SARS-like coronaviruses in horseshoe bats and genetic variation analysis JF Journal of General Virology, VO 87 IS 11 SP 3355 OP 3359 DO https://doi.org/10.1099/vir.0.82220-0 PB Microbiology Society, SN 1465-2099, AB Bats were recently identified as natural reservoirs of SARS-like coronavirus (SL-CoV) or SARS coronavirus-like virus. These viruses, together with SARS coronaviruses (SARS-CoV) isolated from human and palm civet, form a distinctive cluster within the group 2 coronaviruses of the genus Coronavirus, tentatively named group 2b (G2b). In this study, complete genome sequences of two additional group 2b coronaviruses (G2b-CoVs) were determined from horseshoe bat Rhinolophus ferrumequinum (G2b-CoV Rf1) and Rhinolophus macrotis (G2b-CoV Rm1). The bat G2b-CoV isolates have an identical genome organization and share an overall genome sequence identity of 88–92 % among themselves and between them and the human/civet isolates. The most variable regions are located in the genes encoding nsp3, ORF3a, spike protein and ORF8 when bat and human/civet G2b-CoV isolates are compared. Genetic analysis demonstrated that a diverse G2b-CoV population exists in the bat habitat and has evolved from a common ancestor of SARS-CoV., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/vir.0.82220-0