1887

Abstract

(BRSV) is able to counteract the alpha/beta interferon (IFN-/)-mediated antiviral response for efficient replication in a host-specific manner. Mice models have been developed for experimental infection with human, but not bovine, respiratory syncytial virus strains. Here, it is shown that BRSV can replicate efficiently on primary cell cultures derived from type I IFN receptor-deficient, but not from wild-type IFN-competent, mice. However, BRSV infection was not enhanced in mice devoid of the type I IFN receptor. These results show that type I IFN is a major host-range determinant for infection at the cellular level, but that other factors control virus replication and pathology .

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2006-08-01
2019-11-17
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References

  1. Almeida, R. S., Domingues, H. G., Coswig, L. T., D'Arce, R. C. F., de Carvalho, R. F. & Arns, C. W. ( 2004; ). Detection of bovine respiratory syncytial virus in experimentally infected balb/c mice. Vet Res 35, 189–197.[CrossRef]
    [Google Scholar]
  2. Bossert, B. & Conzelmann, K.-K. ( 2002; ). Respiratory syncytial virus (RSV) nonstructural (NS) proteins as host range determinants: a chimeric bovine RSV with NS genes from human RSV is attenuated in interferon-competent bovine cells. J Virol 76, 4287–4293.[CrossRef]
    [Google Scholar]
  3. Bossert, B., Marozin, S. & Conzelmann, K.-K. ( 2003; ). Nonstructural proteins NS1 and NS2 of bovine respiratory syncytial virus block activation of interferon regulatory factor 3. J Virol 77, 8661–8668.[CrossRef]
    [Google Scholar]
  4. Boxus, M., Letellier, C. & Kerkhofs, P. ( 2005; ). Real time RT-PCR for the detection and quantitation of bovine respiratory syncytial virus. J Virol Methods 125, 125–130.[CrossRef]
    [Google Scholar]
  5. Collins, P. L., Chanock, R. M. & Murphy, B. R. ( 2001; ). Respiratory syncytial virus. In Fields Virology, 4th edn, pp. 1443–1485. Edited by D. M. Knipe & P. M. Howley. Philadelphia, PA: Lippincott Williams & Wilkins.
  6. Conzelmann, K.-K. ( 2005; ). Transcriptional activation of alpha/beta interferon genes: interference by nonsegmented negative-strand RNA viruses. J Virol 79, 5241–5248.[CrossRef]
    [Google Scholar]
  7. Jefferies, C. A. & Fitzgerald, K. A. ( 2005; ). Interferon gene regulation: not all roads lead to Tolls. Trends Mol Med 11, 403–411.[CrossRef]
    [Google Scholar]
  8. Johnson, T. R., Mertz, S. E., Gitiban, N., Hammond, S., Legallo, R., Durbin, R. K. & Durbin, J. E. ( 2005; ). Role for innate IFNs in determining respiratory syncytial virus immunopathology. J Immunol 174, 7234–7241.[CrossRef]
    [Google Scholar]
  9. Larsen, L. E. ( 2000; ). Bovine respiratory syncytial virus (BRSV): a review. Acta Vet Scand 41, 1–24.
    [Google Scholar]
  10. Lo, M. S., Brazas, R. M. & Holtzman, M. J. ( 2005; ). Respiratory syncytial virus nonstructural proteins NS1 and NS2 mediate inhibition of Stat2 expression and alpha/beta interferon responsiveness. J Virol 79, 9315–9319.[CrossRef]
    [Google Scholar]
  11. Moynagh, P. N. ( 2005; ). TLR signalling and activation of IRFs: revisiting old friends from the NF-κB pathway. Trends Immunol 26, 469–476.[CrossRef]
    [Google Scholar]
  12. Müller, U., Steinhoff, U., Reis, L. F. L., Hemmi, S., Pavlovic, J., Zinkernagel, R. M. & Aguet, M. ( 1994; ). Functional role of type I and type II interferons in antiviral defense. Science 264, 1918–1921.[CrossRef]
    [Google Scholar]
  13. Ramaswamy, M., Shi, L., Monick, M. M., Hunninghake, G. W. & Look, D. C. ( 2004; ). Specific inhibition of type I interferon signal transduction by respiratory syncytial virus. Am J Respir Cell Mol Biol 30, 893–900.[CrossRef]
    [Google Scholar]
  14. Ramaswamy, M., Shi, L., Varga, S. M., Barik, S., Behlke, M. A. & Look, D. C. ( 2006; ). Respiratory syncytial virus nonstructural protein 2 specifically inhibits type I interferon signal transduction. Virology 344, 328–339.[CrossRef]
    [Google Scholar]
  15. Riffault, S., Eloranta, M. L., Carrat, C., Sandberg, K., Charley, B. & Alm, G. ( 1996; ). Herpes simplex virus induces appearance of interferon-alpha/beta-producing cells and partially interferon-alpha/beta-dependent accumulation of leukocytes in murine regional lymph nodes. J Interferon Cytokine Res 16, 1007–1014.
    [Google Scholar]
  16. Schlender, J., Bossert, B., Buchholz, U. & Conzelmann, K.-K. ( 2000; ). Bovine respiratory syncytial virus nonstructural proteins NS1 and NS2 cooperatively antagonize alpha/beta interferon-induced antiviral response. J Virol 74, 8234–8242.[CrossRef]
    [Google Scholar]
  17. Schlender, J., Hornung, V., Finke, S. & 7 other authors ( 2005; ). Inhibition of Toll-like receptor 7- and 9-mediated alpha/beta interferon production in human plasmacytoid dendritic cells by respiratory syncytial virus and measles virus. J Virol 79, 5507–5515.[CrossRef]
    [Google Scholar]
  18. Spann, K. M., Tran, K. C., Chi, B., Rabin, R. L. & Collins, P. L. ( 2004; ). Suppression of the induction of alpha, beta, and lambda interferons by the NS1 and NS2 proteins of human respiratory syncytial virus in human epithelial cells and macrophages [corrected]. J Virol 78, 4363–4369.[CrossRef]
    [Google Scholar]
  19. Valarcher, J.-F., Schelcher, F. & Bourhy, H. ( 2000; ). Evolution of bovine respiratory syncytial virus. J Virol 74, 10714–10728.[CrossRef]
    [Google Scholar]
  20. Valarcher, J.-F., Furze, J., Wyld, S., Cook, R., Conzelmann, K.-K. & Taylor, G. ( 2003; ). Role of alpha/beta interferons in the attenuation and immunogenicity of recombinant bovine respiratory syncytial viruses lacking NS proteins. J Virol 77, 8426–8439.[CrossRef]
    [Google Scholar]
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