1887

Abstract

An open question amongst papillomavirus taxonomists is whether recombination has featured in the evolutionary history of these viruses. Since the onset of the global AIDS epidemic, the question is somewhat less academic, because immune-compromised human immunodeficiency virus patients are often co-infected with extraordinarily diverse mixtures of human papillomavirus (HPV) types. It is expected that these conditions may facilitate the emergence of HPV recombinants, some of which might have novel pathogenic properties. Here, a range of rigorous analyses is applied to full-genome sequences of papillomaviruses to provide convincing statistical and phylogenetic evidence that evolutionarily relevant papillomavirus recombination can occur.

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2006-09-01
2019-11-15
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PV whole-genome sequences used in recombination analysis [ PDF] (119 KB)

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Recombination programs [ PDF] (382 KB)

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Please click to download the rdp.zipfile, unzip it and then run setup.exe from the RDP folder.

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Please click to download the data_sets.zipfile folder and use RDP to view these data files in the folder.

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