1887

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Volume 87, Issue 9

E (XSR) element contributes to the oncogenicity of (subgroup J) Free

Abstract

Among the six subgroups of (ALV) that infect chickens, subgroup J (ALV-J) was isolated from meat-type chickens where it predominantly induces myeloid leukosis (ML) and erythroblastosis (EB). The sequence of HPRS-103, the ALV-J prototype virus, shows several distinct features, one of which is the presence of a distinct hairpin stem–loop structure called the E (also called XSR) element in the 3′ untranslated region. In order to determine the role of the E element in ALV-induced pathogenicity, a comparison was made of the oncogenicity of viruses derived from the provirus clones of parental and E element-deleted HPRS-103 viruses in two genetically distinct lines of birds. In line 15I birds, deletion of the E element had profound effects on virus replication , as only 55 % of birds showed evidence of infection, compared with 100 % infection by the parental virus. Furthermore, none of the line 15I birds infected with this virus developed tumours, indicating that the E element does contribute to the oncogenicity of the virus. On the other hand, deletion of the E element had only a marginal effect on the incidence of tumours in line 0 birds. These results indicate that, although the E element is not absolutely essential for tumour induction by this subgroup of viruses, it does contribute to oncogenicity in certain genetic lines of chicken.

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2006-09-01
2024-04-19
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E (XSR) element contributes to the oncogenicity of Avian leukosis virus (subgroup J)
J. Gen. Virol. 87, 2685 (2006); https://doi.org/10.1099/vir.0.81884-0
/content/journal/jgv/10.1099/vir.0.81884-0
/content/journal/jgv/10.1099/vir.0.81884-0
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