1887

Abstract

Infection of mice with or results in the activation of a gene encoding a novel, non-coding RNA (ncRNA) in the mouse central nervous system. This transcript, named virus-inducible ncRNA (VINC), is identical to a 3.18 kb transcript expressed in mouse neonate skin (GenBank accession no. AK028745) that, together with a number of unannotated cDNAs and expressed sequence tags, is grouped in the mouse unigene cluster Mm281895. VINC is expressed constitutively in early mouse embryo and several adult non-neuronal mouse tissues, as well as a murine renal adenocarcinoma (RAG) cell line. Northern blotting of nuclear and cytoplasmic RNAs revealed that VINC is localized primarily in the nucleus of RAG cells and is thus a novel member of the nuclear ncRNA family.

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2006-07-01
2024-11-10
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References

  1. Biswas S., Reddy G. S., Srinivasan V. A., Rangarajan P. N. 2001; Preexposure efficacy of a novel combination DNA and inactivated rabies virus vaccine. Hum Gene Ther 12:1917–1922 [CrossRef]
    [Google Scholar]
  2. Booth S., Bowman C., Baumgartner R., Sorenson G., Robertson C., Coulthart M., Phillipson C., Somorjai R. L. 2004; Identification of central nervous system genes involved in the host response to the scrapie agent during preclinical and clinical infection. J Gen Virol 85:3459–3471 [CrossRef]
    [Google Scholar]
  3. Brockdorff N., Ashworth A., Kay G. F., McCabe V. M., Norris D. P., Cooper P. J., Swift S., Rastan S. 1992; The product of the mouse Xist gene is a 15 kb inactive X-specific transcript containing no conserved ORF and located in the nucleus. Cell 71:515–526 [CrossRef]
    [Google Scholar]
  4. Chao Y.-C., Lee S.-T., Chang M.-C., Chen H.-H., Chen S.-S., Wu T.-Y., Liu F.-H., Hsu E.-L., Hou R. F. 1998; A 2.9-kilobase noncoding nuclear RNA functions in the establishment of persistent Hz-1 viral infection. J Virol 72:2233–2245
    [Google Scholar]
  5. Costa F. F. 2005; Non-coding RNAs: new players in eukaryotic biology. Gene 357:83–94 [CrossRef]
    [Google Scholar]
  6. Décimo D., Georges-Labouesse E., Dollé P. 1995; In situ hybridization of nucleic acid probes to cellular RNA. In Gene Probes 2: A Practical Approach pp  182–209 Edited by Hames B. D., Higgins S. J. Oxford: IRL Press;
    [Google Scholar]
  7. Franke A., Baker B. S. 1999; The rox1 and rox2 RNAs are essential components of the compensasome, which mediates dosage compensation in Drosophila . Mol Cell 4:117–122 [CrossRef]
    [Google Scholar]
  8. Gruslin E., Moisan S., St-Pierre Y., Desforges M., Talbot P. J. 2005; Transcriptome profile within the mouse central nervous system and activation of myelin-reactive T cells following murine coronavirus infection. J Neuroimmunol 162:60–70 [CrossRef]
    [Google Scholar]
  9. Imamura T., Yamamoto S., Ohgane J., Hattori N., Tanaka S., Shiota K. 2004; Non-coding RNA directed DNA demethylation of Sphk1 CpG island. Biochem Biophys Res Commun 322:593–600 [CrossRef]
    [Google Scholar]
  10. Jenner R. G., Young R. A. 2005; Insights into host responses against pathogens from transcriptional profiling. Nat Rev Microbiol 3:281–294 [CrossRef]
    [Google Scholar]
  11. Johnston C., Jiang W., Chu T., Levine B. 2001; Identification of genes involved in the host response to neurovirulent alphavirus infection. J Virol 75:10431–10445 [CrossRef]
    [Google Scholar]
  12. Kato N., Harada F. 1985; New U1 RNA species found in Friend SFFV (spleen focus forming virus)-transformed mouse cells. J Biol Chem 260:7775–7782
    [Google Scholar]
  13. Kohtz J. D., Fishell G. 2004; Developmental regulation of EVF-1 , a novel non-coding RNA transcribed upstream of the mouse Dlx6 gene. Gene Expr Patterns 4:407–412 [CrossRef]
    [Google Scholar]
  14. Labrada L., Liang X. H., Zheng W., Johnston C., Levine B. 2002; Age-dependent resistance to lethal alphavirus encephalitis in mice: analysis of gene expression in the central nervous system and identification of a novel interferon-inducible protective gene, mouse ISG12 . J Virol 76:11688–11703 [CrossRef]
    [Google Scholar]
  15. Liu A. Y., Torchia B. S., Migeon B. R., Siliciano R. F. 1997; The human NTT gene: identification of a novel 17-kb noncoding nuclear RNA expressed in activated CD4+ T cells. Genomics 39:171–184 [CrossRef]
    [Google Scholar]
  16. Prosniak M., Hooper D. C., Dietzschold B., Koprowski H. 2001; Effect of rabies virus infection on gene expression in mouse brain. Proc Natl Acad Sci U S A 98:2758–2763 [CrossRef]
    [Google Scholar]
  17. Saha S., Rangarajan P. N. 2003; Common host genes are activated in mouse brain by Japanese encephalitis and rabies viruses. J Gen Virol 84:1729–1735 [CrossRef]
    [Google Scholar]
  18. Sawata M., Yoshino D., Takeuchi H., Kamikouchi A., Ohashi K., Kubo T. 2002; Identification and punctate nuclear localization of a novel noncoding RNA, Ks-1, from the honeybee brain. RNA 8:772–785 [CrossRef]
    [Google Scholar]
  19. Storz G. 2002; An expanding universe of noncoding RNAs. Science 296:1260–1263 [CrossRef]
    [Google Scholar]
  20. Young T. L., Matsuda T., Cepko C. L. 2005; The noncoding RNA Taurine upregulated gene 1 is required for differentiation of the murine retina. Curr Biol 15:501–512 [CrossRef]
    [Google Scholar]
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