1887

Abstract

Random-source DNA samples obtained from naturally infected laboratory mice (=381) were evaluated by PCR and RFLP analysis to determine the prevalence of murine parvovirus strains circulating in contemporary laboratory mouse colonies. Mouse parvovirus (MPV) was detected in 77 % of samples, (MVM) was detected in 16 % of samples and both MVM and MPV were detected in 7 % of samples. MVMm, a strain recently isolated from clinically ill NOD- chain knockout mice, was detected in 91 % of MVM-positive samples, with the Cutter strain of MVM (MVMc) detected in the remaining samples. The prototypic and immunosuppressive strains of MVM were not detected in any of the samples. MPV-1 was detected in 78 % of the MPV-positive samples and two newly identified murine parvoviruses, tentatively named MPV-2 and MPV-3, were detected in 21 and 1 % of the samples, respectively. The DNA sequence encompassing coding regions of the viral genome and the predicted protein sequences for MVMm, MPV-2 and MPV-3 were determined and compared with those of other rodent parvovirus strains and LuIII parvovirus. The genomic organization for the newly identified viral strains was similar to that of other rodent parvoviruses, and nucleotide sequence identities indicated that MVMm was most similar to MVMc (96.1 %), MPV-3 was most similar to hamster parvovirus (HaPV) (98.1 %) and MPV-2 was most similar to MPV-1 (95.3 %). The genetic similarity of MPV-3 and HaPV suggests that HaPV epizootics in hamsters may result from cross-species transmission, with mice as the natural rodent host for this virus.

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2006-06-01
2019-10-20
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References

  1. Agbandje-McKenna, M., Llamas-Saiz, A. L., Wang, F., Tattersall, P. & Rossmann, M. G. ( 1998; ). Functional implications of the structure of the murine parvovirus, minute virus of mice. Structure 6, 1369–1381.[CrossRef]
    [Google Scholar]
  2. Ball-Goodrich, L. J. & Tattersall, P. ( 1992; ). Two amino acid substitutions within the capsid are coordinately required for acquisition of fibrotropism by the lymphotropic strain of minute virus of mice. J Virol 66, 3415–3423.
    [Google Scholar]
  3. Ball-Goodrich, L. J. & Johnson, E. ( 1994; ). Molecular characterization of a newly recognized mouse parvovirus. J Virol 68, 6476–6486.
    [Google Scholar]
  4. Ball-Goodrich, L. J., Leland, S. E., Johnson, E. A., Paturzo, F. X. & Jacoby, R. O. ( 1998; ). Rat parvovirus type 1: the prototype for a new rodent parvovirus serogroup. J Virol 72, 3289–3299.
    [Google Scholar]
  5. Besselsen, D. G., Pintel, D. J., Purdy, G. A., Besch-Williford, C. L., Franklin, C. L., Hook, R. R., Jr & Riley, L. K. ( 1996; ). Molecular characterization of newly recognized rodent parvoviruses. J Gen Virol 77, 899–911.[CrossRef]
    [Google Scholar]
  6. Besselsen, D. G., Gibson, S. V., Besch-Williford, C. L. & 7 other authors ( 1999; ). Natural and experimentally induced infection of Syrian hamsters with a newly recognized parvovirus. Lab Anim Sci 49, 308–312.
    [Google Scholar]
  7. Besselsen, D. G., Wagner, A. M. & Loganbill, J. K. ( 2000; ). Effect of mouse strain and age on detection of mouse parvovirus 1 by use of serologic testing and polymerase chain reaction analysis. Comp Med 50, 498–502.
    [Google Scholar]
  8. Bonnard, G. D., Manders, E. K., Campbell, D. A., Jr, Herberman, R. B. & Collins, M. J., Jr ( 1976; ). Immunosuppressive activity of a subline of the mouse EL-4 lymphoma. Evidence for minute virus of mice causing the inhibition. J Exp Med 143, 187–205.[CrossRef]
    [Google Scholar]
  9. Brownstein, D. G., Smith, A. L., Jacoby, R. O., Johnson, E. A., Hansen, G. & Tattersall, P. ( 1991; ). Pathogenesis of infection with a virulent allotropic variant of minute virus of mice and regulation by host genotype. Lab Invest 65, 357–364.
    [Google Scholar]
  10. Brownstein, D. G., Smith, A. L., Johnson, E. A., Pintel, D. J., Naeger, L. K. & Tattersall, P. ( 1992; ). The pathogenesis of infection with minute virus of mice depends on expression of the small nonstructural protein NS2 and on the genotype of the allotropic determinants VP1 and VP2. J Virol 66, 3118–3124.
    [Google Scholar]
  11. Chang, S.-F., Sgro, J.-Y. & Parrish, C. R. ( 1992; ). Multiple amino acids in the capsid structure of canine parvovirus coordinately determine the canine host range and specific antigenic and hemagglutination properties. J Virol 66, 6858–6867.
    [Google Scholar]
  12. Christensen, J., Cotmore, S. F. & Tattersall, P. ( 1995; ). Minute virus of mice transcriptional activator protein NS1 binds directly to the transactivation region of the viral P38 promoter in a strictly ATP-dependent manner. J Virol 69, 5422–5430.
    [Google Scholar]
  13. Clemens, K. E. & Pintel, D. ( 1987; ). Minute virus of mice (MVM) mRNAs predominantly polyadenylate at a single site. Virology 160, 511–514.[CrossRef]
    [Google Scholar]
  14. Clemens, K. E., Cerutis, D. R., Burger, L. R., Yang, C. Q. & Pintel, D. J. ( 1990; ). Cloning of minute virus of mice cDNAs and preliminary analysis of individual viral proteins expressed in murine cells. J Virol 64, 3967–3973.
    [Google Scholar]
  15. Collins, M. J., Jr & Parker, J. C. ( 1972; ). Murine virus contaminants of leukemia viruses and transplantable tumors. J Natl Cancer Inst 49, 1139–1143.
    [Google Scholar]
  16. Cotmore, S. F. & Tattersall, P. ( 1986; ). Organization of nonstructural genes of the autonomous parvovirus minute virus of mice. J Virol 58, 724–732.
    [Google Scholar]
  17. Cotmore, S. F. & Tattersall, P. ( 1987; ). The autonomously replicating parvoviruses of vertebrates. Adv Virus Res 33, 91–174.
    [Google Scholar]
  18. Cotmore, S. F. & Tattersall, P. ( 1990; ). Alternate splicing in a parvoviral nonstructural gene links a common amino-terminal sequence to downstream domains which confer radically different localization and turnover characteristics. Virology 177, 477–487.[CrossRef]
    [Google Scholar]
  19. Cotmore, S. F. & Tattersall, P. ( 1995; ). DNA replication in the autonomous parvoviruses. Semin Virol 6, 271–281.[CrossRef]
    [Google Scholar]
  20. Cotmore, S. F., Christensen, J., Nüesch, J. P. & Tattersall, P. ( 1995; ). The NS1 polypeptide of the murine parvovirus minute virus of mice binds to DNA sequences containing the motif [ACCA]2-3. J Virol 69, 1652–1660.
    [Google Scholar]
  21. Cotmore, S. F., D'Abramo, A. M., Jr, Carbonell, L. F., Bratton, J. & Tattersall, P. ( 1997; ). The NS2 polypeptide of parvovirus MVM is required for capsid assembly in murine cells. Virology 231, 267–280.[CrossRef]
    [Google Scholar]
  22. Crawford, L. V. ( 1966; ). A minute virus of mice. Virology 29, 605–612.[CrossRef]
    [Google Scholar]
  23. Crawford, L. V., Follett, E. A., Burdon, M. G. & McGeoch, D. J. ( 1969; ). The DNA of a minute virus of mice. J Gen Virol 4, 37–46.[CrossRef]
    [Google Scholar]
  24. Dhawan, R., Henderson, K. S., Cowley, J. P., Wunderlich, M. L., Blank, W. A. & Shek, W. R. ( 2004; ). Serological and nucleic acid sequence characterization of a newly identified mouse parvovirus strain. Contemp Top Lab Anim Sci 43, 43.
    [Google Scholar]
  25. Eichwald, V., Daeffler, L., Klein, M., Rommelaere, J. & Salome, N. ( 2002; ). The NS2 proteins of parvovirus minute virus of mice are required for efficient nuclear egress of progeny virions in mouse cells. J Virol 76, 10307–10319.[CrossRef]
    [Google Scholar]
  26. Engers, H. D., Louis, J. A., Zubler, R. H. & Hirt, B. ( 1981; ). Inhibition of T cell-mediated functions by MVM(i), a parvovirus closely related to minute virus of mice. J Immunol 127, 2280–2285.
    [Google Scholar]
  27. Farr, G. A. & Tattersall, P. ( 2004; ). A conserved leucine that constricts the pore through the capsid fivefold cylinder plays a central role in parvoviral infection. Virology 323, 243–256.[CrossRef]
    [Google Scholar]
  28. Fikrig, M. K. & Tattersall, P. ( 1992; ). Latent parvoviral infection of continuous cell lines. Dev Biol Stand 76, 285–293.
    [Google Scholar]
  29. Garant, P. R., Baer, P. N. & Kilham, L. ( 1980; ). Electron microscopic localization of virions in developing teeth of young hamsters infected with minute virus of mice. J Dent Res 59, 80–86.[CrossRef]
    [Google Scholar]
  30. Garnick, R. L. ( 1996; ). Experience with viral contamination in cell culture. Dev Biol Stand 88, 49–56.
    [Google Scholar]
  31. Garnick, R. L. ( 1998; ). Raw materials as a source of contamination in large-scale cell culture. Dev Biol Stand 93, 21–29.
    [Google Scholar]
  32. Giese, N. A., Lang, S., Raykov, Z., Rommelaere, J., Dinsart, C. & Cornelis, J. J. ( 2000; ). Oncosuppressive effects of wild-type MVMp and recombinant derivates in immunocompetent mice. Infect Dis Rev 2, 153–154.
    [Google Scholar]
  33. Govindasamy, L., Hueffer, K., Parrish, C. R. & Agbandje-McKenna, M. ( 2003; ). Structures of host range-controlling regions of the capsids of canine and feline parvoviruses and mutants. J Virol 77, 12211–12221.[CrossRef]
    [Google Scholar]
  34. Guetta, E., Graziani, Y. & Tal, J. ( 1986; ). Suppression of Ehrlich ascites tumors in mice by minute virus of mice. J Natl Cancer Inst 76, 1177–1180.
    [Google Scholar]
  35. Harris, R. E., Coleman, P. H. & Morahan, P. S. ( 1974; ). Stability of minute virus of mice to chemical and physical agents. Appl Microbiol 28, 351–354.
    [Google Scholar]
  36. Hueffer, K. & Parrish, C. R. ( 2003; ). Parvovirus host range, cell tropism and evolution. Curr Opin Microbiol 6, 392–398.[CrossRef]
    [Google Scholar]
  37. Jacoby, R. O., Johnson, E. A., Ball-Goodrich, L., Smith, A. L. & McKisic, M. D. ( 1995; ). Characterization of mouse parvovirus infection by in situ hybridization. J Virol 69, 3915–3919.
    [Google Scholar]
  38. Jacoby, R. O., Ball-Goodrich, L. J., Besselsen, D. G., McKisic, M. D., Riley, L. K. & Smith, A. L. ( 1996; ). Rodent parvovirus infections. Lab Anim Sci 46, 370–380.
    [Google Scholar]
  39. Jindal, H. K., Yong, C. B., Wilson, G. M., Tam, P. & Astell, C. R. ( 1994; ). Mutations in the NTP-binding motif of minute virus of mice (MVM) NS-1 protein uncouple ATPase and DNA helicase functions. J Biol Chem 269, 3283–3289.
    [Google Scholar]
  40. Jongeneel, C. V., Sahli, R., McMaster, G. K. & Hirt, B. ( 1986; ). A precise map of splice junctions in the mRNAs of minute virus of mice, an autonomous parvovirus. J Virol 59, 564–573.
    [Google Scholar]
  41. Kaufmann, B., Simpson, A. A. & Rossmann, M. G. ( 2004; ). The structure of human parvovirus B19. Proc Natl Acad Sci U S A 101, 11628–11633.[CrossRef]
    [Google Scholar]
  42. Kilham, L. ( 1960; ). Mongolism associated with rat virus (RV) infection in hamsters. Virology 13, 141–143.
    [Google Scholar]
  43. Kilham, L. ( 1961; ). Rat virus (RV) infections in hamsters. Proc Soc Exp Biol Med 106, 825–829.[CrossRef]
    [Google Scholar]
  44. Kilham, L. & Margolis, G. ( 1964; ). Cerebellar ataxia in hamsters inoculated with rat virus. Science 143, 1047–1048.[CrossRef]
    [Google Scholar]
  45. Kilham, L. & Margolis, G. ( 1970; ). Pathogenicity of minute virus of mice (MVM) for rats, mice, and hamsters. Proc Soc Exp Biol Med 133, 1447–1452.[CrossRef]
    [Google Scholar]
  46. Kimsey, P. B., Engers, H. D., Hirt, B. & Jongeneel, C. V. ( 1986; ). Pathogenicity of fibroblast- and lymphocyte-specific variants of minute virus of mice. J Virol 59, 8–13.
    [Google Scholar]
  47. Labieniec-Pintel, L. & Pintel, D. ( 1986; ). The minute virus of mice P39 transcription unit can encode both capsid proteins. J Virol 57, 1163–1167.
    [Google Scholar]
  48. Lamana, M. L., Albella, B., Bueren, J. A. & Segovia, J. C. ( 2001; ). In vitro and in vivo susceptibility of mouse megakaryocytic progenitors to strain i of parvovirus minute virus of mice. Exp Hematol 29, 1303–1309.[CrossRef]
    [Google Scholar]
  49. Livingston, R. S. & Riley, L. K. ( 2003; ). Diagnostic testing of mouse and rat colonies for infectious agents. Lab Anim 32, 44–51.
    [Google Scholar]
  50. Livingston, R. S., Besselsen, D. G., Steffen, E. K., Besch-Williford, C. L., Franklin, C. L. & Riley, L. K. ( 2002; ). Serodiagnosis of mice minute virus and mouse parvovirus infections in mice by enzyme-linked immunosorbent assay with baculovirus-expressed recombinant VP2 proteins. Clin Diagn Lab Immunol 9, 1025–1031.
    [Google Scholar]
  51. Llamas-Saiz, A. L., Agbandje-McKenna, M., Wikoff, W. R., Bratton, J., Tattersall, P. & Rossmann, M. G. ( 1997; ). Structure determination of minute virus of mice. Acta Crystallogr D Biol Crystallogr 53, 93–102.[CrossRef]
    [Google Scholar]
  52. Lombardo, E., Ramírez, J. C., Agbandje-McKenna, M. & Almendral, J. M. ( 2000; ). A beta-stranded motif drives capsid protein oligomers of the parvovirus minute virus of mice into the nucleus for viral assembly. J Virol 74, 3804–3814.[CrossRef]
    [Google Scholar]
  53. Lombardo, E., Ramírez, J. C., Garcia, J. & Almendral, J. M. ( 2002; ). Complementary roles of multiple nuclear targeting signals in the capsid proteins of the parvovirus minute virus of mice during assembly and onset of infection. J Virol 76, 7049–7059.[CrossRef]
    [Google Scholar]
  54. Maxwell, I. H., Spitzer, A. L., Maxwell, F. & Pintel, D. J. ( 1995; ). The capsid determinant of fibrotropism for the MVMp strain of minute virus of mice functions via VP2 and not VP1. J Virol 69, 5829–5832.
    [Google Scholar]
  55. McKenna, R., Olson, N. H., Chipman, P. R. & 8 other authors ( 1999; ). Three-dimensional structure of Aleutian mink disease parvovirus: implications for disease pathogenicity. J Virol 73, 6882–6891.
    [Google Scholar]
  56. McKisic, M. D., Lancki, D. W., Otto, G., Padrid, P., Snook, S., Cronin, D. C., II, Lohmar, P. D., Wong, T. & Fitch, F. W. ( 1993; ). Identification and propagation of a putative immunosuppressive orphan parvovirus in cloned T cells. J Immunol 150, 419–428.
    [Google Scholar]
  57. McKisic, M. D., Paturzo, F. X. & Smith, A. L. ( 1996; ). Mouse parvovirus infection potentiates rejection of tumor allografts and modulates T cell effector functions. Transplantation 61, 292–299.[CrossRef]
    [Google Scholar]
  58. McMaster, G. K., Beard, P., Engers, H. D. & Hirt, B. ( 1981; ). Characterization of an immunosuppressive parvovirus related to the minute virus of mice. J Virol 38, 317–326.
    [Google Scholar]
  59. Miller, C. L. & Pintel, D. J. ( 2002; ). Interaction between parvovirus NS2 protein and nuclear export factor Crm1 is important for viral egress from the nucleus of murine cells. J Virol 76, 3257–3266.[CrossRef]
    [Google Scholar]
  60. Morgan, W. R. & Ward, D. C. ( 1986; ). Three splicing patterns are used to excise the small intron common to all minute virus of mice RNAs. J Virol 60, 1170–1174.
    [Google Scholar]
  61. Naeger, L. K., Cater, J. & Pintel, D. J. ( 1990; ). The small nonstructural protein (NS2) of the parvovirus minute virus of mice is required for efficient DNA replication and infectious virus production in a cell-type-specific manner. J Virol 64, 6166–6175.
    [Google Scholar]
  62. Naeger, L. K., Salome, N. & Pintel, D. J. ( 1993; ). NS2 is required for efficient translation of viral mRNA in minute virus of mice-infected murine cells. J Virol 67, 1034–1043.
    [Google Scholar]
  63. Naugler, S. L., Myles, M. H., Bauer, B. A., Kennett, M. J. & Besch-Williford, C. L. ( 2001; ). Reduced fecundity and death associated with parvovirus infection in B-lymphocyte deficient mice. Contemp Top Lab Anim Sci 40, 66.
    [Google Scholar]
  64. Nicklas, W., Kraft, V. & Meyer, B. ( 1993; ). Contamination of transplantable tumors, cell lines, and monoclonal antibodies with rodent viruses. Lab Anim Sci 43, 296–300.
    [Google Scholar]
  65. Nüesch, J. P., Cotmore, S. F. & Tattersall, P. ( 1995; ). Sequence motifs in the replicator protein of parvovirus MVM essential for nicking and covalent attachment to the viral origin: identification of the linking tyrosine. Virology 209, 122–135.[CrossRef]
    [Google Scholar]
  66. Padron, E., Bowman, V., Kaludov, N. & 8 other authors ( 2005; ). Structure of adeno-associated virus type 4. J Virol 79, 5047–5058.[CrossRef]
    [Google Scholar]
  67. Parker, J. S. & Parrish, C. R. ( 1997; ). Canine parvovirus host range is determined by the specific conformation of an additional region of the capsid. J Virol 71, 9214–9222.
    [Google Scholar]
  68. Parrish, C. R. ( 1991; ). Mapping specific functions in the capsid structure of canine parvovirus and feline panleukopenia virus using infectious plasmid clones. Virology 183, 195–205.[CrossRef]
    [Google Scholar]
  69. Plyusnin, A. & Morzunov, S. P. ( 2001; ). Virus evolution and genetic diversity of hantaviruses and their rodent hosts. Curr Top Microbiol Immunol 256, 47–75.
    [Google Scholar]
  70. Redig, A. J. & Besselsen, D. G. ( 2001; ). Detection of rodent parvoviruses by fluorogenic nuclease polymerase chain reaction. Comp Med 51, 326–331.
    [Google Scholar]
  71. Segovia, J. C., Real, A., Bueren, J. A. & Almendral, J. M. ( 1991; ). In vitro myelosuppressive effects of the parvovirus minute virus of mice (MVMi) on hematopoietic stem and committed progenitor cells. Blood 77, 980–988.
    [Google Scholar]
  72. Segovia, J. C., Bueren, J. A. & Almendral, J. M. ( 1995; ). Myeloid depression follows infection of susceptible newborn mice with the parvovirus minute virus of mice (strain i). J Virol 69, 3229–3232.
    [Google Scholar]
  73. Segovia, J. C., Gallego, J. M., Bueren, J. A. & Almendral, J. M. ( 1999; ). Severe leukopenia and dysregulated erythropoiesis in SCID mice persistently infected with the parvovirus minute virus of mice. J Virol 73, 1774–1784.
    [Google Scholar]
  74. Shackelton, L. A., Parrish, C. R., Truyen, U. & Holmes, E. C. ( 2005; ). High rate of viral evolution associated with the emergence of carnivore parvovirus. Proc Natl Acad Sci U S A 102, 379–384.[CrossRef]
    [Google Scholar]
  75. Shek, W. R., Paturzo, F. X., Johnson, E. A., Hansen, G. M. & Smith, A. L. ( 1998; ). Characterization of mouse parvovirus infection among BALB/c mice from an enzootically infected colony. Lab Anim Sci 48, 294–297.
    [Google Scholar]
  76. Simpson, A. A., Hebert, B., Sullivan, G. M., Parrish, C. R., Zadori, Z., Tijssen, P. & Rossmann, M. G. ( 2002; ). The structure of porcine parvovirus: comparison with related viruses. J Mol Biol 315, 1189–1198.[CrossRef]
    [Google Scholar]
  77. Smith, A. L. ( 1983; ). Response of weanling random-bred mice to inoculation with minute virus of mice. Lab Anim Sci 33, 37–39.
    [Google Scholar]
  78. Smith, A. L., Jacoby, R. O., Johnson, E. A., Paturzo, F. & Bhatt, P. N. ( 1993; ). In vivo studies with an “orphan” parvovirus of mice. Lab Anim Sci 43, 175–182.
    [Google Scholar]
  79. Tattersall, P. & Bratton, J. ( 1983; ). Reciprocal productive and restrictive virus–cell interactions of immunosuppressive and prototype strains of minute virus of mice. J Virol 46, 944–955.
    [Google Scholar]
  80. Tattersall, P., Cawte, P. J., Shatkin, A. J. & Ward, D. C. ( 1976; ). Three structural polypeptides coded for by minute virus of mice, a parvovirus. J Virol 20, 273–289.
    [Google Scholar]
  81. Toolan, H. W. ( 1960; ). Experimental production of mongoloid hamsters. Science 131, 1446–1448.[CrossRef]
    [Google Scholar]
  82. Tresnan, D. B., Southard, L., Weichert, W., Sgro, J.-Y. & Parrish, C. R. ( 1995; ). Analysis of the cell and erythrocyte binding activities of the dimple and canyon regions of the canine parvovirus capsid. Virology 211, 123–132.[CrossRef]
    [Google Scholar]
  83. Tsao, J., Chapman, M. S., Agbandje, M. & 7 other authors ( 1991; ). The three-dimensional structure of canine parvovirus and its functional implications. Science 251, 1456–1464.[CrossRef]
    [Google Scholar]
  84. Walters, R. W., Agbandje-McKenna, M., Bowman, V. D., Moninger, T. O., Olson, N. H., Seiler, M., Chiorini, J. A., Baker, T. S. & Zabner, J. ( 2004; ). Structure of adeno-associated virus serotype 5. J Virol 78, 3361–3371.[CrossRef]
    [Google Scholar]
  85. Wan, C.-H., Söderlund-Venermo, M., Pintel, D. J. & Riley, L. K. ( 2002; ). Molecular characterization of three newly recognized rat parvoviruses. J Gen Virol 83, 2075–2083.
    [Google Scholar]
  86. Wilson, G. M., Jindal, H. K., Yeung, D. E., Chen, W. & Astell, C. R. ( 1991; ). Expression of minute virus of mice major nonstructural protein in insect cells: purification and identification of ATPase and helicase activities. Virology 185, 90–98.[CrossRef]
    [Google Scholar]
  87. Zadori, Z., Szelei, J., Lacoste, M. C., Li, Y., Gariepy, S., Raymond, P., Allaire, M., Nabi, I. R. & Tijssen, P. ( 2001; ). A viral phospholipase A2 is required for parvovirus infectivity. Dev Cell 1, 291–302.[CrossRef]
    [Google Scholar]
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