RT Journal Article SR Electronic(1) A1 Li, Hong A1 Gailbreath, Katherine A1 Flach, Edmund J. A1 Taus, Naomi S. A1 Cooley, Jim A1 Keller, Janice A1 Russell, George C. A1 Knowles, Donald P. A1 Haig, David M. A1 Oaks, J. Lindsay A1 Traul, Donald L. A1 Crawford, Timothy B.YR 2005 T1 A novel subgroup of rhadinoviruses in ruminants JF Journal of General Virology, VO 86 IS 11 SP 3021 OP 3026 DO https://doi.org/10.1099/vir.0.81238-0 PB Microbiology Society, SN 1465-2099, AB In the course of investigating the malignant catarrhal fever (MCF) subgroup of rhadinoviruses, seven novel rhadinoviruses were identified in a variety of ruminants, including domestic sheep, bighorn sheep, bison, black-tailed deer, mule deer, fallow deer, elk and addax. Based on the DNA polymerase gene sequences, these newly recognized viruses clustered into a second distinct subgroup in ruminants with three members identified previously in cattle, goats and oryx. Phylogenetic analysis revealed that the currently known ruminant rhadinoviruses appear to comprise three distinct genetic lineages: (i) the MCF subgroup, defined by sequence identity and the presence of the 15A antigenic epitope; (ii) a second distinct subgroup, devoid of the 15A epitope, which contains the previously reported bovine lymphotropic herpesvirus and related viruses; and (iii) a third distinct subgroup represented by Bovine herpesvirus 4. Comparison of phylogenetic trees between the rhadinoviruses and their corresponding hosts further supports the gammaherpesvirus and host co-evolution theory., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/vir.0.81238-0