RT Journal Article SR Electronic(1) A1 Carmona, Pedro A1 Monzón, Marta A1 Monleón, Eva A1 Badiola, Juan José A1 Monreal, JaimeYR 2005 T1 In vivo detection of scrapie cases from blood by infrared spectroscopy JF Journal of General Virology, VO 86 IS 12 SP 3425 OP 3431 DO https://doi.org/10.1099/vir.0.81097-0 PB Microbiology Society, SN 1465-2099, AB In the present study, infrared spectroscopy was shown to be able to distinguish healthy and scrapie-infected animals by analysis of the white-cell membranous fraction from blood. Infrared spectroscopy was able to detect not only clinical cases, but also animals at a preclinical stage of the disease. These findings suggest this technique as an accurate in vivo diagnostic tool that could be applied to animal as well as human samples. In addition to possibly avoiding the slaughter of a huge number of animals with the socio-economic consequences that this poses, the test could be expected to become useful in the prevention of human transmission by blood transfusion., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/vir.0.81097-0