Skip to content
1887

Journal of General Virology header logo Journal of General Virology

Volume 86, Issue 8

A novel homologue of in chimpanzees No Access

Abstract

Among the , human cytomegalovirus is the only virus to possess simian homologues. Indeed, intriguingly, no close simian homologue of the roseoloviruses (HHV-6) and (HHV-7), the other two human members of the , has been identified to date. Here, the first simian homologue of HHV-6 is described, which was identified in common chimpanzees and designated PanHV6. By using a degenerate consensus PCR method, three different gene fragments were amplified, corresponding to the DNA polymerase (U38), -chemokine receptor (U12) and viral transactivator (U42) genes, with 94–96 % (nucleotide) and 95–97 % (amino acid) sequence identity to the corresponding genes of HHV-6B. Analysis of 77 predominantly wild-caught chimpanzees identified a unique PanHV6 strain in 21 animals, with no viral sequence variation between the different chimpanzee subspecies that were found to be infected. Characterization of this virus represents a great potential to gain a better understanding of the diseases associated with HHV-6.

  • Received:
  • Accepted:
  • Published Online:
SGM
Loading

Article metrics loading...

/content/journal/jgv/10.1099/vir.0.81034-0
2005-08-01
2025-04-20
Loading full text...

Full text loading...

References

  1. Ablashi D. V., Balachandran N., Josephs S. F., Hung C. L., Krueger G. R. F., Kramarsky B., Salahuddin S. Z., Gallo R. C. 1991; Genomic polymorphism, growth properties, and immunologic variations in human herpesvirus-6 isolates. Virology 184:545–552 [CrossRef]
     [Google Scholar]
  2. Agut H. 1993; Puzzles concerning the pathogenicity of human herpesvirus 6. N Engl J Med 329:203–204 [CrossRef]
     [Google Scholar]
  3. Blewett E. L., White G., Saliki J. T., Eberle R. 2001; Isolation and characterization of an endogenous cytomegalovirus (BaCMV) from baboons. Arch Virol 146:1723–1738 [CrossRef]
     [Google Scholar]
  4. Challoner P. B., Smith K. T., Parker J. D. 12 other authors 1995; Plaque-associated expression of human herpesvirus 6 in multiple sclerosis. Proc Natl Acad Sci U S A 92:7440–7444 [CrossRef]
     [Google Scholar]
  5. Clark D. A. 2000; Human herpesvirus 6. Rev Med Virol 10:155–173 [CrossRef]
     [Google Scholar]
  6. Davison A. J., Dolan A., Akter P., Addison C., Dargan D. J., Alcendor D. J., McGeoch D. J., Hayward G. S. 2003; The human cytomegalovirus genome revisited: comparison with the chimpanzee cytomegalovirus genome. J Gen Virol 84:17–28 [CrossRef]
     [Google Scholar]
  7. Dockrell D. H. 2003; Human herpesvirus 6: molecular biology and clinical features. J Med Microbiol 52:5–18 [CrossRef]
     [Google Scholar]
  8. Dominguez G., Dambaugh T. R., Stamey F. R., Dewhurst S., Inoue N., Pellett P. E. 1999; Human herpesvirus 6B genome sequence: coding content and comparison with human herpesvirus 6A. J Virol 73:8040–8052
     [Google Scholar]
  9. Ehlers B., Ochs A., Leendertz F., Goltz M., Boesch C., Mätz-Rensing K. 2003; Novel simian homologues of Epstein-Barr virus. J Virol 77:10695–10699 [CrossRef]
     [Google Scholar]
  10. Felsenstein J. 1993 phylip (phylogeny inference package), version 3.52c. Department of Genome Sciences University of Washington; Seattle, USA:
     [Google Scholar]
  11. Fillet A.-M., Lozeron P., Agut H., Lyon-Caen O., Liblau R. 1998; HHV-6 and multiple sclerosis. Nat Med 4:537 [CrossRef]
     [Google Scholar]
  12. Hall C. B., Long C. E., Schnabel K. C. 7 other authors 1994; Human herpesvirus-6 infection in children – a prospective study of complications and reactivation. N Engl J Med 331:432–438 [CrossRef]
     [Google Scholar]
  13. Hall C. B., Caserta M. T., Schnabel K. C., Long C., Epstein L. G., Insel R. A., Dewhurst S. 1998; Persistence of human herpesvirus 6 according to site and variant: possible greater neurotropism of variant A. Clin Infect Dis 26:132–137 [CrossRef]
     [Google Scholar]
  14. Higashi K., Asada H., Kurata T., Ishikawa K., Hayami M., Spriatna Y., Sutarman & Yamanishi K. 1989; Presence of antibody to human herpesvirus 6 in monkeys. J Gen Virol 70:3171–3176 [CrossRef]
     [Google Scholar]
  15. Isegawa Y., Ping Z., Nakano K., Sugimoto N., Yamanishi K. 1998; Human herpesvirus 6 open reading frame U12 encodes a functional β -chemokine receptor. J Virol 72:6104–6112
     [Google Scholar]
  16. Isegawa Y., Mukai T., Nakano K. 10 other authors 1999; Comparison of the complete DNA sequences of human herpesvirus 6 variants A and B. J Virol 73:8053–8063
     [Google Scholar]
  17. Jenson H. B., Ench Y., Zhang Y., Gao S.-J., Arrand J. R., Mackett M. 2002; Characterization of an Epstein–Barr virus-related gammaherpesvirus from common marmoset ( Callithrix jacchus ). J Gen Virol 83:1621–1633
     [Google Scholar]
  18. Kasolo F. C., Mpabalwani E., Gompels U. A. 1997; Infection with AIDS-related herpesviruses in human immunodeficiency virus-negative infants and endemic childhood Kaposi's sarcoma in Africa. J Gen Virol 78:847–855
     [Google Scholar]
  19. Lacoste V., Mauclère P., Dubreuil G., Lewis J., Georges-Courbot M.-C., Gessain A. 2000a; KSHV-like herpesviruses in chimps and gorillas. Nature 407:151–152 [CrossRef]
     [Google Scholar]
  20. Lacoste V., Mauclère P., Dubreuil G., Lewis J., Georges-Courbot M.-C., Rigoulet J., Petit T., Gessain A. 2000b; Simian homologues of human gamma-2 and betaherpesviruses in mandrill and drill monkeys. J Virol 74:11993–11999 [CrossRef]
     [Google Scholar]
  21. Lacoste V., Mauclère P., Dubreuil G., Lewis J., Georges-Courbot M.-C., Gessain A. 2001; A novel γ 2-herpesvirus of the rhadinovirus 2 lineage in chimpanzees. Genome Res 11:1511–1519 [CrossRef]
     [Google Scholar]
  22. Le Cleach L., Fillet A. M., Agut H., Chosidow O. 1998; Human herpesviruses 6 and 7: new roles yet to be discovered?. Arch Dermatol 134:1155–1157
     [Google Scholar]
  23. Lusso P., Markham P. D., DeRocco S. E., Gallo R. C. 1990; In vitro susceptibility of T lymphocytes from chimpanzees ( Pan troglodytes ) to human herpesvirus 6 (HHV-6): a potential animal model to study the interaction between HHV-6 and human immunodeficiency virus type 1 in vivo. J Virol 64:2751–2758
     [Google Scholar]
  24. McGeoch D. J., Cook S., Dolan A., Jamieson F. E., Telford E. A. R. 1995; Molecular phylogeny and evolutionary timescale for the family of mammalian herpesviruses. J Mol Biol 247:443–458 [CrossRef]
     [Google Scholar]
  25. Murphy P. M. 2001; Viral exploitation and subversion of the immune system through chemokine mimicry. Nat Immunol 2:116–122 [CrossRef]
     [Google Scholar]
  26. Niphuis H., Verschoor E. J., Bontjer I., Peeters M., Heeney J. L. 2003; Reduced transmission and prevalence of simian T-cell lymphotropic virus in a closed breeding colony of chimpanzees ( Pan troglodytes verus ). J Gen Virol 84:615–620 [CrossRef]
     [Google Scholar]
  27. Raftery M., Müller A., Schönrich G. 2000; Herpesvirus homologues of cellular genes. Virus Genes 21:65–75 [CrossRef]
     [Google Scholar]
  28. Rose T. M., Strand K. B., Schultz E. R., Schaefer G., Rankin G. W. Jr, Thouless M. E., Tsai C.-C., Bosch M. L. 1997; Identification of two homologs of the Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) in retroperitoneal fibromatosis of different macaque species. J Virol 71:4138–4144
     [Google Scholar]
  29. Salahuddin S. Z., Ablashi D. V., Markham P. D. 8 other authors 1986; Isolation of a new virus, HBLV, in patients with lymphoproliferative disorders. Science 234:596–601 [CrossRef]
     [Google Scholar]
  30. Schirmer E. C., Wyatt L. S., Yamanishi K., Rodriguez W. J., Frenkel N. 1991; Differentiation between two distinct classes of viruses now classified as human herpesvirus 6. Proc Natl Acad Sci U S A 88:5922–5926 [CrossRef]
     [Google Scholar]
  31. Soldan S. S., Berti R., Salem N. 9 other authors 1997; Association of human herpes virus 6 (HHV-6) with multiple sclerosis: increased IgM response to HHV-6 early antigen and detection of serum HHV-6 DNA. Nat Med 3:1394–1397 [CrossRef]
     [Google Scholar]
  32. Tuke P. W., Hawke S., Griffiths P. D., Clark D. A. 2004; Distribution and quantification of human herpesvirus 6 in multiple sclerosis and control brains. Mult Scler 10:355–359 [CrossRef]
     [Google Scholar]
  33. Yamanishi K., Okuno T., Shiraki K., Takahashi M., Kondo T., Asano Y., Kurata T. 1988; Identification of human herpesvirus-6 as a causal agent for exanthem subitum. Lancet i:1065–1067
     [Google Scholar]
  34. Zerr D. M., Meier A. S., Selke S. S. 8 other authors 2005; A population-based study of primary human herpesvirus 6 infection. N Engl J Med 352:768–776 [CrossRef]
     [Google Scholar]
/content/journal/jgv/10.1099/vir.0.81034-0
Loading
A novel homologue of Human herpesvirus 6 in chimpanzees
J. Gen. Virol. 86, 2135 (2005); https://doi.org/10.1099/vir.0.81034-0
/content/journal/jgv/10.1099/vir.0.81034-0
/content/journal/jgv/10.1099/vir.0.81034-0
Loading

Data & Media loading...

Supplements

Supplementary material 1

PDF

Most cited Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error