@article{mbs:/content/journal/jgv/10.1099/vir.0.80823-0, author = "Karakasiliotis, Ioannis and Paximadi, Eleni and Markoulatos, Panayotis", title = "Evolution of a rare vaccine-derived multirecombinant poliovirus", journal= "Journal of General Virology", year = "2005", volume = "86", number = "11", pages = "3137-3142", doi = "https://doi.org/10.1099/vir.0.80823-0", url = "https://www.microbiologyresearch.org/content/journal/jgv/10.1099/vir.0.80823-0", publisher = "Microbiology Society", issn = "1465-2099", type = "Journal Article", abstract = "Recombination is one of the mechanisms by which viral genomes evolve. A vaccine-derived multirecombinant poliovirus strain was isolated from a 5-month-old child with vaccine-associated paralytic poliomyelitis after oral poliovirus vaccine administration. The isolate had an S2/S1/S2/S1 primary genomic structure as revealed by restriction fragment length polymorphism and sequencing analysis. Recombination of the middle S1/S2 region is extremely rare and one of the few characterized types of recombination with Sabin type 1 as a 5′ partner. An attempt was made to perform evolutionary analysis of the contributing sequences using the identified mutations in comparison with the original Sabin sequences. A hypothesis is proposed for the order in which the identified recombination events occurred.", }