1887

Abstract

Recombination is one of the mechanisms by which viral genomes evolve. A vaccine-derived multirecombinant poliovirus strain was isolated from a 5-month-old child with vaccine-associated paralytic poliomyelitis after oral poliovirus vaccine administration. The isolate had an S2/S1/S2/S1 primary genomic structure as revealed by restriction fragment length polymorphism and sequencing analysis. Recombination of the middle S1/S2 region is extremely rare and one of the few characterized types of recombination with Sabin type 1 as a 5′ partner. An attempt was made to perform evolutionary analysis of the contributing sequences using the identified mutations in comparison with the original Sabin sequences. A hypothesis is proposed for the order in which the identified recombination events occurred.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/vir.0.80823-0
2005-11-01
2024-04-18
Loading full text...

Full text loading...

/deliver/fulltext/jgv/86/11/3137.html?itemId=/content/journal/jgv/10.1099/vir.0.80823-0&mimeType=html&fmt=ahah

References

  1. Agol V. I. 1997; Recombination and other genomic rearrangements in picornaviruses. Semin Virol 8:77–84 [CrossRef]
    [Google Scholar]
  2. Bellmunt A., May G., Zell R., Pring-Akerblom P., Verhagen W., Heim A. 1999; Evolution of poliovirus type I during 5·5 years of prolonged enteral replication in an immunodeficient patient. Virology 265:178–184 [CrossRef]
    [Google Scholar]
  3. Blomqvist S., Bruu A. L., Stenvik M., Hovi T. 2003; Characterization of a recombinant type 3/type 2 poliovirus isolated from a healthy vaccinee and containing a chimeric capsid protein VP1. J Gen Virol 84:573–580 [CrossRef]
    [Google Scholar]
  4. Blomqvist S., Savolainen C., Laine P., Hirttio P., Lamminsalo E., Penttila E., Joks S., Roivainen M., Hovi T. 2004; Characterization of a highly evolved vaccine-derived poliovirus type 3 isolated from sewage in Estonia. J Virol 78:4876–4883 [CrossRef]
    [Google Scholar]
  5. Casas I., Powell L., Klapper P. E., Cleator G. M. 1995; New method for the extraction of viral RNA and DNA from cerebrospinal fluid for use in the polymerase chain reaction assay. J Virol Methods 53:25–36 [CrossRef]
    [Google Scholar]
  6. Cuervo N. S., Guillot S., Romanenkova N., Combiescu M., Aubert-Combiescu A., Seghier M., Caro V., Crainic R., Delpeyroux F. 2001; Genomic features of intertypic recombinant sabin poliovirus strains excreted by primary vaccinees. J Virol 75:5740–5751 [CrossRef]
    [Google Scholar]
  7. Domingo E., Holland J. J. 1997; RNA virus mutations and fitness for survival. Annu Rev Microbiol 51:151–178 [CrossRef]
    [Google Scholar]
  8. Drake J. W., Holland J. J. 1999; Mutation rates among RNA viruses. Proc Natl Acad Sci U S A 96:13910–13913 [CrossRef]
    [Google Scholar]
  9. Driesel G., Diedrich S., Kunkel U., Schreier E. 1995; Vaccine-associated cases of poliomyelitis over 30 year period in East Germany. Eur J Epidemiol 11:647–654 [CrossRef]
    [Google Scholar]
  10. Gavrilin G. V., Cherkasova E. A., Lipskaya G. Y., Kew O. M., Agol V. I. 2000; Evolution of circulating wild poliovirus and of vaccine-derived poliovirus in an immunodeficient patient: a unifying model. J Virol 74:7381–7390 [CrossRef]
    [Google Scholar]
  11. Georgescu M. M., Delpeyroux F., Tardy-Panit M., Balanant J., Combiescu M., Combiescu A. A., Guillot S., Crainic R. 1994; High diversity of poliovirus strains isolated from the central nervous system from patients with vaccine-associated paralytic poliomyelitis. J Virol 68:8089–8101
    [Google Scholar]
  12. Georgescu M. M., Delpeyroux F., Crainic R. 1995; Tripartite genome organization of a natural type 2 vaccine/nonvaccine recombinant poliovirus. J Gen Virol 76:2343–2348 [CrossRef]
    [Google Scholar]
  13. Georgescu M. M., Balanant J., Ozden S., Crainic R. 1997; Random selection: a model for poliovirus infection of the central nervous system. J Gen Virol 78:1819–1828
    [Google Scholar]
  14. Georgopoulou A., Markoulatos P. 2001; Sabin type 2 polioviruses with intertypic vaccine/vaccine recombinant genomes. Eur J Clin Microbiol Infect Dis 20:792–799 [CrossRef]
    [Google Scholar]
  15. Georgopoulou A., Markoulatos P., Spyrou N., Vamvakopoulos N. C. 2000; Improved genotyping of vaccine and wild type poliovirus strains by restriction fragment length polymorphism analysis: clinical diagnostic implications. J Clin Microbiol 141:1047–1054
    [Google Scholar]
  16. Guillot S., Caro V., Cuervo N., Korotkova E., Combiescu M., Persu A., Aubert-Combiescu A., Delpeyroux F., Crainic R. 2000; Natural genetic exchanges between vaccine and wild poliovirus strains in humans. J Virol 74:8434–8443 [CrossRef]
    [Google Scholar]
  17. Karakasiliotis I., Markoulatos P., Katsorchis T. 2004; Site analysis of recombinant and mutant poliovirus isolates of Sabin origin from patients and from vaccinees. Mol Cell Probes 18:103–109 [CrossRef]
    [Google Scholar]
  18. Kew O., Morris-Glasgow V., Landaverde M. 21 other authors 2002; Outbreak of poliomyelitis in Hispaniola associated with circulating type 1 vaccine-derived poliovirus. Science 296:356–359 [CrossRef]
    [Google Scholar]
  19. Khetsuriani N., Prevots D. R., Quick L., Elder M. E., Pallansch M., Kew O., Sutter R. W. 2003; Persistence of vaccine-derived polioviruses among immunodeficient persons with vaccine-associated paralytic poliomyelitis. J Infect Dis 188:1845–1852 [CrossRef]
    [Google Scholar]
  20. Li W. H., Wu C. I., Luo C. C. 1985; A new method for estimating synonymous and nonsynonymous rates of nucleotide substitution considering the relative likelihood of nucleotide and codon changes. Mol Biol Evol 2:150–174
    [Google Scholar]
  21. Liu H. M., Zheng D. P., Zhang L. B., Oberste M. S., Pallansch M. A., Kew O. M. 2000; Molecular evolution of a type 1 wild-vaccine poliovirus recombinant during widespread circulation in China. J Virol 74:11153–11161 [CrossRef]
    [Google Scholar]
  22. Liu H. M., Zheng D. P., Zhang L. B., Oberste M. S., Kew O. M., Pallansch M. A. 2003; Serial recombination during circulation of type 1 wild-vaccine recombinant polioviruses in China. J Virol 77:10994–11005 [CrossRef]
    [Google Scholar]
  23. MacLennan C., Dunn G., Huissoon A. P. 9 other authors 2004; Failure to clear persistent vaccine-derived neurovirulent poliovirus infection in an immunodeficient man. Lancet 363:1509–1513 [CrossRef]
    [Google Scholar]
  24. Rezapkin G. V., Chumakov K. M., Lu Z., Ran Y., Dragunsky E. M., Levenbook I. S. 1994; Microevolution of Sabin 1 strain in vitro and genetic stability of oral poliovirus vaccine. Virology 202:370–378 [CrossRef]
    [Google Scholar]
  25. Rezapkin G. V., Fan L., Asher D. M., Fibi M. R., Dragunsky E. M., Chumakov K. M. 1999; Mutations in Sabin 2 strain of poliovirus and stability of attenuation phenotype. Virology 258:152–160 [CrossRef]
    [Google Scholar]
  26. Vinje J., Gregoricus N., Martin J. 11 other authors 2004; Isolation and characterization of circulating type 1 vaccine-derived poliovirus from sewage and stream waters in Hispaniola. J Infect Dis 189:1168–1175 [CrossRef]
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/vir.0.80823-0
Loading
/content/journal/jgv/10.1099/vir.0.80823-0
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error