1887

Abstract

The Japanese Red Cross has been conducting a nucleic acid amplification test (NAT) screening for hepatitis B virus (HBV), hepatitis C virus and human immunodeficiency virus 1 among blood donors since July 1 1999. The first case of HBV genotype H was found and reported in Japan. Serological markers of HBV were not detected in this NAT-positive donation. It may be that the positive donation was in the serological window period at the early stage of infection. The complete genome of 3215 nt was sequenced, and the sequence had 99·3 % homology with the strain from Los Angeles, USA (LSA2523). Here, a leucine zipper motif was found in the region of the HBV surface antigen conserved through genotypes A–H.

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2005-03-01
2019-11-17
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References

  1. Arauz-Ruiz, P., Norder, H., Visona, K. A. & Magnius, L. O. ( 1997; ). Molecular epidemiology of hepatitis B virus in Central America reflected in the genetic variability of the small S gene. J Infect Dis 176, 851–858.[CrossRef]
    [Google Scholar]
  2. Arauz-Ruiz, P., Norder, H., Robertson, B. H. & Magnius, L. O. ( 2002; ). Genotype H: a new Amerindian genotype of hepatitis B virus revealed in Central America. J Gen Virol 83, 2059–2073.
    [Google Scholar]
  3. Galibert, F., Mandart, E., Fitoussi, F., Tiollais, P. & Charnay, P. ( 1979; ). Nucleotide sequence of the hepatitis B virus genome (subtype ayw) cloned in E. coli. Nature 281, 646–650.[CrossRef]
    [Google Scholar]
  4. Kato, H., Gish, R. G., Bzowej, N. & 9 other authors ( 2004; ). Eight genotypes (A-H) of hepatitis B virus infecting patients from San Francisco and their demographic, clinical, and virological characteristics. J Med Virol 73, 516–521.[CrossRef]
    [Google Scholar]
  5. Kobayashi, M., Arase, Y., Ikeda, K. & 10 other authors ( 2002; ). Clinical characteristics of patients infected with hepatitis B virus genotypes A, B, and C. J Gastroenterol 37, 35–39.[CrossRef]
    [Google Scholar]
  6. Koibuchi, T., Hitani, A., Nakamura, T., Nojiri, N., Nakajima, K., Jyuji, T. & Iwamoto, A. ( 2001; ). Predominance of genotype A HBV in an HBV-HIV-1 dually positive population compared with an HIV-1-negative counterpart in Japan. J Med Virol 64, 435–440.[CrossRef]
    [Google Scholar]
  7. Landschulz, W. H., Johnson, P. F. & Mcknight, S. L. ( 1988; ). The leucine zipper: a hypothetical structure common to a new class of DNA-binding proteins. Science 240, 1759–1764.[CrossRef]
    [Google Scholar]
  8. Locarnini, S. A. ( 2002; ). Clinical relevance of viral dynamics and genotypes in hepatitis B. J Gastroenterol Hepatol 17, S322–S328.[CrossRef]
    [Google Scholar]
  9. Mangold, C. M. T. & Streeck, R. E. ( 1993; ). Mutational analysis of cysteine residues in the hepatitis B virus small envelope protein. J Virol 67, 4588–4597.
    [Google Scholar]
  10. Mayerat, C., Mantegani, A. & Frei, P. C. ( 1999; ). Does hepatitis B virus (HBV) genotype influence the clinical outcome of HBV infection? J Viral Hepat 6, 299–304.[CrossRef]
    [Google Scholar]
  11. Mine, H., Emura, H., Miyamoto, M. & 7 other authors ( 2003; ). High throughput screening of 16 million serologically negative blood donors for hepatitis B virus, hepatitis C virus and human immunodeficiency virus type-1 by nucleic acid amplification testing with specific and sensitive multiplex reagent in Japan. J Virol Methods 112, 145–151.[CrossRef]
    [Google Scholar]
  12. Minegishi, K., Yoshikawa, A., Kishimoto, S., Yugi, H., Yokoya, N., Sakurada, M., Kiyokawa, H., Nishioka, K. & the Japanese Red Cross NAT Screening Research Group ( 2003; ). Superiority of minipool nucleic acid amplification technology for hepatitis B virus over chemiluminescence immunoassay for hepatitis B surface antigen screening. Vox Sang 84, 287–291.[CrossRef]
    [Google Scholar]
  13. Nei, M. ( 1987; ). Phylogenetic trees. In Molecular Evolutionary Genetics, pp. 287–326. Edited by M. Nei. New York: Columbia University Press.
  14. Norder, H., Hammas, B., Löfdahl, S., Couroucé, A. M. & Magnius, L. O. ( 1992; ). Comparison of the amino acid sequences of nine different serotypes of hepatitis B surface antigen and genomic classification of the corresponding hepatitis B virus strains. J Gen Virol 73, 1201–1208.[CrossRef]
    [Google Scholar]
  15. Norder, H., Hammas, B., Lee, S. D., Bile, K., Couroucé, A. M., Mushahwar, I. K. & Magnius, L. O. ( 1993; ). Genetic relatedness of hepatitis B viral strains of diverse geographical origin and natural variations in the primary structure of the surface antigen. J Gen Virol 74, 1341–1348.[CrossRef]
    [Google Scholar]
  16. Norder, H., Couroucé, A. M. & Magnius, L. O. ( 1994; ). Complete genomes, phylogenetic relatedness, and structural proteins of six strains of the hepatitis B virus, four of which represent two new genotypes. Virology 198, 489–503.[CrossRef]
    [Google Scholar]
  17. Ohtake, K. & Nishioka, K. ( 2000; ). Nucleic acid amplification testing of hepatitis B virus. Lancet 355, 1460.
    [Google Scholar]
  18. Okamoto, H., Imai, M., Miyakawa, Y. & Mayumi, M. ( 1987a; ). Site-directed mutagenesis of hepatitis B surface antigen sequence at codon 160 from arginine to lysine for conversion of subtype determinant from r to w. Biochem Biophys Res Commun 148, 500–504.[CrossRef]
    [Google Scholar]
  19. Okamoto, H., Imai, M., Tsuda, F., Tanaka, T., Miyakawa, Y. & Mayumi, M. ( 1987b; ). Point mutation in the S gene of hepatitis B virus for a d/y or w/r subtypic change in two blood donors carrying a surface antigen of compound subtype adyr or adwr. J Virol 61, 3030–3034.
    [Google Scholar]
  20. Okamoto, H., Tsuda, F., Sakugawa, H., Sastrosoewignjo, R. I., Imai, M., Miyakawa, Y. & Mayumi, M. ( 1988; ). Typing hepatitis B virus by homology in nucleotide sequence: comparison of surface antigen subtypes. J Gen Virol 69, 2575–2583.[CrossRef]
    [Google Scholar]
  21. Okamoto, H., Yotsumoto, S., Akahane, Y. & 7 other authors ( 1990; ). Hepatitis B viruses with precore region defects prevail in persistently infected hosts along with seroconversion to the antibody against e antigen. J Virol 64, 1298–1303.
    [Google Scholar]
  22. Okamoto, H., Tsuda, F., Akahane, Y., Sugai, Y., Yoshiba, M., Moriyama, K., Tanaka, T., Miyakawa, Y. & Mayumi, M. ( 1994; ). Hepatitis B virus with mutations in the core promoter for an e antigen-negative phenotype in carriers with antibody to e antigens. J Virol 68, 8102–8110.
    [Google Scholar]
  23. Orito, E., Ichida, T., Sakugawa, H. & 11 other authors ( 2001; ). Geographic distribution of hepatitis B virus (HBV) genotype in patients with chronic HBV infection in Japan. Hepatology 34, 590–594.[CrossRef]
    [Google Scholar]
  24. Sánchez, L. V., Maldonado, M., Bastidas-Ramirez, B. E., Norder, H. & Panduro, A. ( 2002; ). Genotypes and S-gene variability of Mexican hepatitis B virus strains. J Med Virol 68, 24–32.[CrossRef]
    [Google Scholar]
  25. Stuyver, L., De Gendt, S., Van Geyt, C., Zoulim, F., Fried, M., Schinazi, R. F. & Rossau, ( 2000; ). A new genotype of hepatitis B virus: complete genome and phylogenetic relatedness. J Gen Virol 81, 67–74.
    [Google Scholar]
  26. Valenzuela, P., Quiroga, M., Zalvidar, J., Gray, P. & Rutter, W. J. ( 1980; ). The nucleotide sequence of the hepatitis B viral genome and the identification of the major viral genes. In Animal Virus Genetics, pp. 57–70. Edited by B. N. Fields, R. Jaenisch. & C. F. Fox. New York: Academic Press.
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