1887

Abstract

As well as being distributed widely in human populations, hepatitis B virus (HBV) infections occur frequently in chimpanzee, gibbon and other ape populations in sub-Saharan Africa and South-East Asia. To investigate the frequency and genetic relationships of HBV infecting gibbons in Cambodia, pileated gibbons () that were originally wild-caught were screened for surface antigen. Twelve of 26 (46 %) were positive, of which 11 were positive for HBV DNA. Phylogenetic analysis of complete genome sequences revealed two distinct genetic groups in the gibbon/orangutan clade. Three were similar to previously described variants infecting in Thailand and eight formed a distinct clade, potentially representing distinct strains of HBV circulating in geographically separated populations in South-East Asia. Because of the ability of HBV to cross species barriers, large reservoirs of infection in gibbons may hamper ongoing attempts at permanent eradication of HBV infection from human populations in South-East Asia through immunization.

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2005-02-01
2019-11-19
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References

  1. Aiba, N., Nishimura, H., Arakawa, Y. & Abe, K. ( 2003; ). Complete nucleotide sequence and phylogenetic analyses of hepatitis B virus isolated from two pileated gibbons. Virus Genes 27, 219–226.[CrossRef]
    [Google Scholar]
  2. André, F. ( 2000; ). Hepatitis B epidemiology in Asia, the Middle East and Africa. Vaccine 18 (Suppl. 1), S20–S22.[CrossRef]
    [Google Scholar]
  3. Arauz-Ruiz, P., Norder, H., Visoná, K. A. & Magnius, L. O. ( 1997; ). Genotype F prevails in HBV infected patients of Hispanic origin in Central America and may carry the precore stop mutant. J Med Virol 51, 305–312.[CrossRef]
    [Google Scholar]
  4. Arauz-Ruiz, P., Norder, H., Robertson, B. H. & Magnius, L. O. ( 2002; ). Genotype H: a new Amerindian genotype of hepatitis B virus revealed in Central America. J Gen Virol 83, 2059–2073.
    [Google Scholar]
  5. Grethe, S., Heckel, J.-O., Rietschel, W. & Hufert, F. T. ( 2000; ). Molecular epidemiology of hepatitis B virus variants in nonhuman primates. J Virol 74, 5377–5381.[CrossRef]
    [Google Scholar]
  6. Hu, X., Margolis, H. S., Purcell, R. H., Ebert, J. & Robertson, B. H. ( 2000; ). Identification of hepatitis B virus indigenous to chimpanzees. Proc Natl Acad Sci U S A 97, 1661–1664.[CrossRef]
    [Google Scholar]
  7. Kao, J.-H. & Chen, D.-S. ( 2002; ). Global control of hepatitis B virus infection. Lancet Infect Dis 2, 395–403.[CrossRef]
    [Google Scholar]
  8. Lanford, R. E., Chavez, D., Rico-Hesse, R. & Mootnick, A. ( 2000; ). Hepadnavirus infection in captive gibbons. J Virol 74, 2955–2959.[CrossRef]
    [Google Scholar]
  9. Lok, A. S. F., Akarca, U. & Greene, S. ( 1994; ). Mutations in the pre-core region of hepatitis B virus serve to enhance the stability of the secondary structure of the pre-genome encapsidation signal. Proc Natl Acad Sci U S A 91, 4077–4081.[CrossRef]
    [Google Scholar]
  10. MacDonald, D. M., Holmes, E. C., Lewis, J. C. M. & Simmonds, P. ( 2000; ). Detection of hepatitis B virus infection in wild-born chimpanzees (Pan troglodytes verus): phylogenetic relationships with human and other primate genotypes. J Virol 74, 4253–4257.[CrossRef]
    [Google Scholar]
  11. Magnius, L. O. & Norder, H. ( 1995; ). Subtypes, genotypes and molecular epidemiology of the hepatitis B virus as reflected by sequence variability of the S-gene. Intervirology 38, 24–34.
    [Google Scholar]
  12. Nakai, K., Win, K. M., Oo, S. S., Arakawa, Y. & Abe, K. ( 2001; ). Molecular characteristic-based epidemiology of hepatitis B, C, and E viruses and GB virus C/hepatitis G virus in Myanmar. J Clin Microbiol 39, 1536–1539.[CrossRef]
    [Google Scholar]
  13. Noppornpanth, S., Haagmans, B. L., Bhattarakosol, P., Ratanakorn, P., Niesters, H. G., Osterhaus, A. D. M. E. & Poovorawan, Y. ( 2003; ). Molecular epidemiology of gibbon hepatitis B virus transmission. J Gen Virol 84, 147–155.[CrossRef]
    [Google Scholar]
  14. Norder, H., Couroucé, A.-M. & Magnius, L. O. ( 1994; ). Complete genomes, phylogenetic relatedness, and structural proteins of six strains of the hepatitis B virus, four of which represent two new genotypes. Virology 198, 489–503.[CrossRef]
    [Google Scholar]
  15. Okamoto, H., Imai, M., Shimozaki, M., Hoshi, Y., Iizuka, H., Gotanda, T., Tsuda, F., Miyakawa, Y. & Mayumi, M. ( 1986; ). Nucleotide sequence of a cloned hepatitis B virus genome, subtype ayr: comparison with genomes of the other three subtypes. J Gen Virol 67, 2305–2314.[CrossRef]
    [Google Scholar]
  16. Simmonds, P. & Smith, D. B. ( 1999; ). Structural constraints on RNA virus evolution. J Virol 73, 5787–5794.
    [Google Scholar]
  17. Starkman, S. E., MacDonald, D. M., Lewis, J. C. M., Holmes, E. C. & Simmonds, P. ( 2003; ). Geographic and species association of hepatitis B virus genotypes in non-human primates. Virology 314, 381–393.[CrossRef]
    [Google Scholar]
  18. Takahashi, K., Brotman, B., Usuda, S., Mishiro, S. & Prince, A. M. ( 2000; ). Full-genome sequence analyses of hepatitis B virus (HBV) strains recovered from chimpanzees infected in the wild: implications for an origin of HBV. Virology 267, 58–64.[CrossRef]
    [Google Scholar]
  19. Thomas, H. C. & Jacyna, M. R. ( 1993; ). Hepatitis B virus: pathogenesis and treatment of chronic infection. In Viral Hepatitis: Scientific Basis and Clinical Management, pp. 185–207. Edited by A. J. Zuckerman & H. C. Thomas. Edinburgh: Churchill Livingstone.
  20. Vartanian, J. P., Pineau, P., Henry, M., Hamilton, W. D., Muller, M. N., Wrangham, R. W. & Wain-Hobson, S. ( 2002; ). Identification of a hepatitis B virus genome in wild chimpanzees (Pan troglodytes schweinfurthi) from East Africa indicates a wide geographical dispersion among equatorial African primates. J Virol 76, 11155–11158.[CrossRef]
    [Google Scholar]
  21. Vaudin, M., Wolstenholme, A. J., Tsiquaye, K. N., Zuckerman, A. J. & Harrison, T. J. ( 1988; ). The complete nucleotide sequence of the genome of a hepatitis B virus isolated from a naturally infected chimpanzee. J Gen Virol 69, 1383–1389.[CrossRef]
    [Google Scholar]
  22. Verschoor, E. J., Warren, K. S., Langenhuijzen, S., Heriyanto, Swan, R. A. & Heeney, J. L. ( 2001; ). Analysis of two genomic variants of orang-utan hepadnavirus and their relationship to other primate hepatitis B-like viruses. J Gen Virol 82, 893–897.
    [Google Scholar]
  23. Warren, K. S., Heeney, J. L., Swan, R. A., Heriyanto & Verschoor, E. J. ( 1999; ). A new group of hepadnaviruses naturally infecting orangutans (Pongo pygmaeus). J Virol 73, 7860–7865.
    [Google Scholar]
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