@article{mbs:/content/journal/jgv/10.1099/vir.0.80102-0, author = "Nishimura, Yorihiro and Shimojima, Masayuki and Sato, Eiji and Izumiya, Yoshihiro and Tohya, Yukinobu and Mikami, Takeshi and Miyazawa, Takayuki", title = "Downmodulation of CD3ε expression in CD8α+β− T cells of feline immunodeficiency virus-infected cats", journal= "Journal of General Virology", year = "2004", volume = "85", number = "9", pages = "2585-2589", doi = "https://doi.org/10.1099/vir.0.80102-0", url = "https://www.microbiologyresearch.org/content/journal/jgv/10.1099/vir.0.80102-0", publisher = "Microbiology Society", issn = "1465-2099", type = "Journal Article", abstract = "Feline immunodeficiency virus (FIV) infection in cats is associated with an increase of feline CD (fCD)8α + β − and fCD8α + β low cells in peripheral blood. To investigate these cells in more detail, an anti-fCD3ε mAb, termed NZM1, was generated, which recognizes the extracellular epitope of the fCD3ε molecule. The anti-fCD3ε mAb proved to be more suitable for identifying feline T cells than the anti-fCD5 one, which has been used as a pan-T-cell reagent in cats, because of the presence of fCD5+fCD3ε − cells among lymphocytes. Although the fCD8α + β − and fCD8α + β low cells in the FIV-infected cats expressed fCD3ε, a subset of fCD8α + β − cells expressed fCD3ε antigen at a lower level than the T cells whose phenotype was fCD4+, or fCD8α + β low. The lower expression of fCD3ε may be associated with the immune status of fCD8α + β − T cells.", }