%0 Journal Article %A Niiya, Hironari %A Azuma, Taichi %A Jin, Lei %A Uchida, Naoyuki %A Inoue, Atsushi %A Hasegawa, Hitoshi %A Fujita, Shigeru %A Tohyama, Mikiko %A Hashimoto, Koji %A Yasukawa, Masaki %T Transcriptional downregulation of DC-SIGN in human herpesvirus 6-infected dendritic cells %D 2004 %J Journal of General Virology, %V 85 %N 9 %P 2639-2642 %@ 1465-2099 %R https://doi.org/10.1099/vir.0.80095-0 %I Microbiology Society, %X DC-SIGN expressed on dendritic cells (DCs) efficiently binds and transmits various pathogens, including human immunodeficiency virus, to lymphoid tissues and permissive cells. Consequently, alteration of DC-SIGN expression may affect susceptibility and resistance to pathogens. The present study shows that infection with human herpesvirus 6 (HHV-6) induces downregulation of DC-SIGN expression on immature DCs. Expression levels of DC-SIGN mRNA and intracellular protein appeared to decrease following infection with HHV-6, indicating that downregulation of surface DC-SIGN occurs at the transcriptional level. Downregulation of DC-SIGN was not induced by inoculation of UV-inactivated HHV-6 or culture supernatant of HHV-6-infected DCs, indicating that replication of HHV-6 in DCs is required for downregulation of DC-SIGN. The present study demonstrates for the first time that expression of DC-SIGN is altered at the transcriptional level by virus infection. %U https://www.microbiologyresearch.org/content/journal/jgv/10.1099/vir.0.80095-0