@article{mbs:/content/journal/jgv/10.1099/vir.0.80095-0, author = "Niiya, Hironari and Azuma, Taichi and Jin, Lei and Uchida, Naoyuki and Inoue, Atsushi and Hasegawa, Hitoshi and Fujita, Shigeru and Tohyama, Mikiko and Hashimoto, Koji and Yasukawa, Masaki", title = "Transcriptional downregulation of DC-SIGN in human herpesvirus 6-infected dendritic cells", journal= "Journal of General Virology", year = "2004", volume = "85", number = "9", pages = "2639-2642", doi = "https://doi.org/10.1099/vir.0.80095-0", url = "https://www.microbiologyresearch.org/content/journal/jgv/10.1099/vir.0.80095-0", publisher = "Microbiology Society", issn = "1465-2099", type = "Journal Article", abstract = "DC-SIGN expressed on dendritic cells (DCs) efficiently binds and transmits various pathogens, including human immunodeficiency virus, to lymphoid tissues and permissive cells. Consequently, alteration of DC-SIGN expression may affect susceptibility and resistance to pathogens. The present study shows that infection with human herpesvirus 6 (HHV-6) induces downregulation of DC-SIGN expression on immature DCs. Expression levels of DC-SIGN mRNA and intracellular protein appeared to decrease following infection with HHV-6, indicating that downregulation of surface DC-SIGN occurs at the transcriptional level. Downregulation of DC-SIGN was not induced by inoculation of UV-inactivated HHV-6 or culture supernatant of HHV-6-infected DCs, indicating that replication of HHV-6 in DCs is required for downregulation of DC-SIGN. The present study demonstrates for the first time that expression of DC-SIGN is altered at the transcriptional level by virus infection.", }